scholarly journals A connectome and analysis of the adult Drosophila central brain

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Louis K Scheffer ◽  
C Shan Xu ◽  
Michal Januszewski ◽  
Zhiyuan Lu ◽  
Shin-ya Takemura ◽  
...  
Keyword(s):  
Large Fraction ◽  
Large Data ◽  
Fruit Fly ◽  
Cell Types ◽  
Large Data Sets ◽  
Data Sets ◽  
Central Brain ◽  
Chemical Synapses ◽  
New Procedures ◽  
Improved Methods

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.

scholarly journals A Connectome and Analysis of the Adult Drosophila Central Brain

2020 ◽  
Author(s):  
Louis K. Scheffer ◽  
C. Shan Xu ◽  
Michal Januszewski ◽  
Zhiyuan Lu ◽  
Shin-ya Takemura ◽  
...  
Keyword(s):  
Large Fraction ◽  
Large Data ◽  
Fruit Fly ◽  
Cell Types ◽  
Large Data Sets ◽  
Data Sets ◽  
Central Brain ◽  
Chemical Synapses ◽  
New Procedures ◽  
Improved Methods

AbstractThe neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.

scholarly journals A Connectome of the Adult Drosophila Central Brain

2020 ◽  
Author(s):  
C. Shan Xu ◽  
Michal Januszewski ◽  
Zhiyuan Lu ◽  
Shin-ya Takemura ◽  
Kenneth J. Hayworth ◽  
...  
Keyword(s):  
Large Fraction ◽  
Large Data ◽  
Fruit Fly ◽  
Cell Types ◽  
Brain Regions ◽  
Central Complex ◽  
Data Set ◽  
New Methods ◽  
Central Brain ◽  
The Brain

AbstractThe neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete circuits of small animals, with hundreds of neurons, and selected circuits for larger animals. Here we (the FlyEM project at Janelia and collaborators at Google) summarize new methods and present the complete circuitry of a large fraction of the brain of a much more complex animal, the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses, and proofread such large data sets; new methods that define cell types based on connectivity in addition to morphology; and new methods to simplify access to a large and evolving data set. From the resulting data we derive a better definition of computational compartments and their connections; an exhaustive atlas of cell examples and types, many of them novel; detailed circuits for most of the central brain; and exploration of the statistics and structure of different brain compartments, and the brain as a whole. We make the data public, with a web site and resources specifically designed to make it easy to explore, for all levels of expertise from the expert to the merely curious. The public availability of these data, and the simplified means to access it, dramatically reduces the effort needed to answer typical circuit questions, such as the identity of upstream and downstream neural partners, the circuitry of brain regions, and to link the neurons defined by our analysis with genetic reagents that can be used to study their functions.Note: In the next few weeks, we will release a series of papers with more involved discussions. One paper will detail the hemibrain reconstruction with more extensive analysis and interpretation made possible by this dense connectome. Another paper will explore the central complex, a brain region involved in navigation, motor control, and sleep. A final paper will present insights from the mushroom body, a center of multimodal associative learning in the fly brain.

An example of spectrum imaging used for comparison of EELS quantitative analysis techniques on Al-Li

1991 ◽  
Vol 49 ◽  
pp. 726-727
Author(s):  
John A. Hunt
Keyword(s):  
Quantitative Analysis ◽  
Large Data ◽  
Difference Spectrum ◽  
Large Data Sets ◽  
Foil Thickness ◽  
Data Sets ◽  
Analysis Techniques ◽  
Spectrum Imaging ◽  
Normal Spectrum ◽  
Electron Energy Loss

Spectrum-imaging is a useful technique for comparing different processing methods on very large data sets which are identical for each method. This paper is concerned with comparing methods of electron energy-loss spectroscopy (EELS) quantitative analysis on the Al-Li system. The spectrum-image analyzed here was obtained from an Al-10at%Li foil aged to produce δ' precipitates that can span the foil thickness. Two 1024 channel EELS spectra offset in energy by 1 eV were recorded and stored at each pixel in the 80x80 spectrum-image (25 Mbytes). An energy range of 39-89eV (20 channels/eV) are represented. During processing the spectra are either subtracted to create an artifact corrected difference spectrum, or the energy offset is numerically removed and the spectra are added to create a normal spectrum. The spectrum-images are processed into 2D floating-point images using methods and software described in [1].

Cluster analysis for large data sets: applications to individual aerosol particles from the mid-pacific

1992 ◽  
Vol 50 (2) ◽  
pp. 1488-1489
Author(s):  
Thomas W. Shattuck ◽  
James R. Anderson ◽  
Neil W. Tindale ◽  
Peter R. Buseck
Keyword(s):  
Cluster Analysis ◽  
Chemical Reactivity ◽  
Large Data ◽  
Large Data Sets ◽  
Particle Analysis ◽  
Data Sets ◽  
Halogen Chemistry ◽  
Complete Study ◽  
Components Analysis ◽  
Automated Scanning

Individual particle analysis involves the study of tens of thousands of particles using automated scanning electron microscopy and elemental analysis by energy-dispersive, x-ray emission spectroscopy (EDS). EDS produces large data sets that must be analyzed using multi-variate statistical techniques. A complete study uses cluster analysis, discriminant analysis, and factor or principal components analysis (PCA). The three techniques are used in the study of particles sampled during the FeLine cruise to the mid-Pacific ocean in the summer of 1990. The mid-Pacific aerosol provides information on long range particle transport, iron deposition, sea salt ageing, and halogen chemistry.Aerosol particle data sets suffer from a number of difficulties for pattern recognition using cluster analysis. There is a great disparity in the number of observations per cluster and the range of the variables in each cluster. The variables are not normally distributed, they are subject to considerable experimental error, and many values are zero, because of finite detection limits. Many of the clusters show considerable overlap, because of natural variability, agglomeration, and chemical reactivity.

NVESTIGATION OF THE EFFICIENCY OF DISTRIBUTED INFORMATION SYSTEMS BASED ON THE PROCESSING OF LARGE AMOUNTS OF DATA

2019 ◽  
Author(s):  
Mykhajlo Klymash ◽  
Olena Hordiichuk — Bublivska ◽  
Ihor Tchaikovskyi ◽  
Oksana Urikova
Keyword(s):  
Distributed Systems ◽  
Large Data ◽  
Large Data Sets ◽  
Data Sets ◽  
Data Decomposition ◽  
Distributed Information ◽  
Software Model ◽  
Computing Performance ◽  
Mapreduce Model ◽  
Singular Data

In this article investigated the features of processing large arrays of information for distributed systems. A method of singular data decomposition is used to reduce the amount of data processed, eliminating redundancy. Dependencies of com­putational efficiency on distributed systems were obtained using the MPI messa­ging protocol and MapReduce node interaction software model. Were analyzed the effici­ency of the application of each technology for the processing of different sizes of data: Non — distributed systems are inefficient for large volumes of information due to low computing performance. It is proposed to use distributed systems that use the method of singular data decomposition, which will reduce the amount of information processed. The study of systems using the MPI protocol and MapReduce model obtained the dependence of the duration calculations time on the number of processes, which testify to the expediency of using distributed computing when processing large data sets. It is also found that distributed systems using MapReduce model work much more efficiently than MPI, especially with large amounts of data. MPI makes it possible to perform calculations more efficiently for small amounts of information. When increased the data sets, advisable to use the Map Reduce model.

Using Large Data Sets and Statistical Tools to Define “Failure” and Demonstrate the Safety of DPR

2018 ◽  
Vol 2018 (6) ◽  
pp. 38-39
Author(s):  
Austa Parker ◽  
Yan Qu ◽  
David Hokanson ◽  
Jeff Soller ◽  
Eric Dickenson ◽  
...  
Keyword(s):  
Large Data ◽  
Large Data Sets ◽  
Data Sets ◽  
Statistical Tools

scholarly journals Online Judging Platform Utilizing Dynamic Plagiarism Detection Facilities

Computers ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 47
Author(s):  
Fariha Iffath ◽  
A. S. M. Kayes ◽  
Md. Tahsin Rahman ◽  
Jannatul Ferdows ◽  
Mohammad Shamsul Arefin ◽  
...  
Keyword(s):  
Source Code ◽  
Large Data ◽  
Large Data Sets ◽  
Detection Technique ◽  
Data Sets ◽  
Plagiarism Detection ◽  
Source Codes ◽  
Efficient Detection ◽  
Mathematical Problems ◽  
Automatic Scoring

A programming contest generally involves the host presenting a set of logical and mathematical problems to the contestants. The contestants are required to write computer programs that are capable of solving these problems. An online judge system is used to automate the judging procedure of the programs that are submitted by the users. Online judges are systems designed for the reliable evaluation of the source codes submitted by the users. Traditional online judging platforms are not ideally suitable for programming labs, as they do not support partial scoring and efficient detection of plagiarized codes. When considering this fact, in this paper, we present an online judging framework that is capable of automatic scoring of codes by detecting plagiarized contents and the level of accuracy of codes efficiently. Our system performs the detection of plagiarism by detecting fingerprints of programs and using the fingerprints to compare them instead of using the whole file. We used winnowing to select fingerprints among k-gram hash values of a source code, which was generated by the Rabin–Karp Algorithm. The proposed system is compared with the existing online judging platforms to show the superiority in terms of time efficiency, correctness, and feature availability. In addition, we evaluated our system by using large data sets and comparing the run time with MOSS, which is the widely used plagiarism detection technique.

Correlations of random classifiers on large data sets

2021 ◽  
Author(s):  
Věra Kůrková ◽  
Marcello Sanguineti
Keyword(s):  
Large Data ◽  
Large Data Sets ◽  
Data Sets
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