scholarly journals Mapping the endemicity and seasonality of clinical malaria for intervention targeting in Haiti using routine case data

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Ewan Cameron ◽  
Alyssa J Young ◽  
Katherine A Twohig ◽  
Emilie Pothin ◽  
Darlene Bhavnani ◽  
...  
Keyword(s):  
Indoor Residual Spraying ◽  
Control Program ◽  
Clinical Malaria ◽  
Malaria Control Program ◽  
Modelling Framework ◽  
National Malaria Control Program ◽  
International Partner ◽  
Spatio Temporal ◽  
Risk Communities ◽  
Case Data

Towards the goal of malaria elimination on Hispaniola, the National Malaria Control Program of Haiti and its international partner organisations are conducting a campaign of interventions targeted to high-risk communities prioritised through evidence-based planning. Here we present a key piece of this planning: an up-to-date, fine-scale endemicity map and seasonality profile for Haiti informed by monthly case counts from 771 health facilities reporting from across the country throughout the 6-year period from January 2014 to December 2019. To this end, a novel hierarchical Bayesian modelling framework was developed in which a latent, pixel-level incidence surface with spatio-temporal innovations is linked to the observed case data via a flexible catchment sub-model designed to account for the absence of data on case household locations. These maps have focussed the delivery of indoor residual spraying and focal mass drug administration in the Grand’Anse Department in South-Western Haiti.

scholarly journals Performance of pirimiphos-methyl based Indoor Residual Spraying on entomological parameters of malaria transmission in the pyrethroid resistance region of Koulikoro, Mali.

2020 ◽  
Author(s):  
Moussa KEITA ◽  
Nafomon SOGOBA ◽  
Boïssé Traoré ◽  
Fousseyni Kané ◽  
Boubacar Coulibaly ◽  
...  
Keyword(s):  
Malaria Transmission ◽  
Pyrethroid Resistance ◽  
Control Strategies ◽  
Indoor Residual Spraying ◽  
Control Program ◽  
Mosquito Vector ◽  
Monthly Basis ◽  
Malaria Control Program ◽  
National Malaria Control Program ◽  
Pirimiphos Methyl

Abstract Background:Vector control relies heavily on Long-lasting insecticidal nets ( (LLINs) and Indoor Residual Spraying (IRS) in selected districts in Mali including Koulikoro district. As part of strengthening vector control strategies in the district, IRS was initiated by the National Malaria Control Program (NMCP) with the support of the US President's Malaria Initiative (PMI) since 2008. LLINs coverage was 93.3% and 98.2% for IRS in Koulikoro, the only district of the region where IRS was supported by PMI. Following mosquito vector resistance to both pyrethroid and carbamates, organophosphate (pirimiphos-methyl) was used for the IRS campaigns of 2015 and 2016 in the district of Koulikoro. In this study, we assessed the effect of IRS on malaria transmission by comparing entomological indices in of the district of Koulikoro, where IRS was implemented and its neighbored district of Banamba, where IRS had never been implemented. Methods:The study was conducted in two villages of each district (Koulikoro and Banamba). Pyrethrum spray catches and entry window trapping were used to collect mosquitoes on a monthly basis. WHO tube tests were carried out to assess mosquito susceptibility to insecticides. Mosquitoes were identified to species level by PCR and their infection to P. falciparum was detected by ELISA.Results:Of the 527 specimens identified, An. coluzzii was the most frequent species (95%) followed by An. gambiae (4%) and An. arabiensis (1%). Its density was rainfall dependent in the no-IRS area, and almost independent in the IRS area. The infection rate (IR) in the no-IRS area was 0.96%, while it was null in the IRS area. In the no-IRS area, the entomological inoculation rates (EIR) was 0.21 infective bites /person month with a peak in September. High resistance to pyrethroids and carbamates and susceptibility to organophosphates was observed at all sites.Conclusion:The introduction of pirimiphos-methyl based IRS in the area resulted in a significant decrease in malaria transmission. An.gambiae s.l., the main malaria vector of the area, was resistant to pyrethroids and carbamates, and remained susceptible to the organophosphates.

scholarly journals Cost Analysis of Insecticide Spraying For Malaria Control In A Terai District Of Eastern Nepal

2016 ◽  
Vol 12 (3) ◽  
pp. 175-179
Author(s):  
Pramod Singh GC ◽  
P K Pokharel
Keyword(s):  
Cost Analysis ◽  
Malaria Control ◽  
Indoor Residual Spraying ◽  
Control Program ◽  
Control Measures ◽  
The Public ◽  
Malaria Control Program ◽  
Disease Control Program ◽  
Malaria Eradication ◽  
The Cost

Background: Malaria is one of the public health problems in Nepal. It is estimated that 25% of population of Nepal are infected by malaria at any time. Malaria control program was first initiated in 1954 with support of USAID through the Insect Born Disease Control Program. This program was changed into Malaria Eradication Program in 1958. The program was reverted to control program in 1978.Objective: The objective of this study was to estimate the cost of insecticide spraying from the provider’s perspective in a Terai district of eastern Nepal.Methods: Morang District of eastern Terai was purposively selected. A pre-tested interview was used to collect data from program managers and government officers in the Malaria Control Program. The main categories of variables were manpower, insecticide, pump and others.Results: The cost for indoor residual spraying per person protected was calculated as Rs.24.70 (US$0.31). This cost was for one cycle and there were two cycles in a year. So the cost per year was Rs.49.40 (US$0.62). The cost per household was calculated as Rs. 129.56 (US$1.65) per cycle and Rs.259.12 and US$3.30 per year for residual spraying.Conclusion: In this cost analysis of indoor residual spraying, the cost per household per year was found Rs. 259.12 and US$3.30. The cost calculated per person protected per year was Rs. 49.40 and US$0.62. This analysis would be more complete if a comparative study of both costs and effectiveness of various vector control measures are undertaken in Nepal.Health Renaissance 2014;12(3): 175-179

scholarly journals Transgenic Mosquitoes Fight against Malaria: A Review

2019 ◽  
Vol 7 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Amit Kumar Shrivastava ◽  
Laxmi Shrestha ◽  
Shraddha Prakash ◽  
Roshan Kumar Mehta
Keyword(s):  
Malaria Control ◽  
Indoor Residual Spraying ◽  
Control Program ◽  
Bed Nets ◽  
Mosquito Vector ◽  
Gene Drive ◽  
Malaria Control Program ◽  
Malaria Burden ◽  
Insecticide Treated Bed Nets ◽  
Transgenic Mosquitoes

Malaria control with transgenic mosquitoes will be challenging; however, recent advances suggest that it may be a possibility in the foreseeable future. Progress towards discovering refractory genes for rodent malaria and gene drive systems for Drosophila provide hope that similar advances may be made for human malaria in mosquito vector species. That said, the African malaria burden has proved exceptionally difficult to diminish by all means tried thus far; and it is unlikely that transgenic mosquitoes will provide an all-in-one solution. Transgenic mosquitoes should be considered within the context of an integrated vector management strategy which should also include insecticide-treated bed-nets, indoor residual spraying with insecticides and treatment of infected individuals with antimalarial drugs. Integrated strategies will be a necessity for any successful african malaria control program and transgenic mosquitoes should be considered as a potential ingredient in the future goal of continent-wide disease control.

scholarly journals Implementation Fidelity of the National Malaria Control Program in Burkina Faso

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69865 ◽  
Author(s):  
Valéry Ridde ◽  
Thomas Druetz ◽  
Serge Poppy ◽  
Seni Kouanda ◽  
Slim Haddad
Keyword(s):  
Burkina Faso ◽  
Malaria Control ◽  
Implementation Fidelity ◽  
Control Program ◽  
Malaria Control Program ◽  
National Malaria Control Program

scholarly journals A rapid, low-cost methodology for longitudinal evaluation of insecticide treated bednet distributions: a pilot survey coupling bednet usage with malaria prevalence at the household level

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Karen B. Jacobson ◽  
Dennis Danforth ◽  
James Lin ◽  
Steven Merjavy ◽  
Brendan Milliner ◽  
...  
Keyword(s):  
Low Cost ◽  
Control Program ◽  
Malaria Prevalence ◽  
Bed Nets ◽  
Distribution Data ◽  
Household Level ◽  
Malaria Control Program ◽  
National Malaria Control Program ◽  
Individual Use ◽  
Distribution Campaign

Tanzania’s National Malaria Control Program distributed 23.3 million insecticidetreated bed nets (ITNs) between 2009 and 2011. Annual randomized household surveys were conducted from 2009 to 2011 to assess the incremental effects of the distribution campaign on malaria prevalence and bednet usage in Kijumbura village in Kagera, Tanzania. Data was collected about household ITN ownership and individual use, and each household member was given a rapid malaria diagnostic test (RDT). In total, 1247 individuals from 285 households participated. From 2009 to 2011, household ITN ownership increased from 50.6 to 95.3% and individual usage increased from 9.7 to 55.3% in 2011. Malaria point prevalence decreased from 15.8% in 2009 to 6.5% in 2010, and increased from 6.5% in 2010 to 10.7% in 2011. The survey cost in 2011 was 23.50 USD per household; major expenses were transportation, personnel payment, and the purchase of the RDTs. Evaluations of bednet distribution programs generally rely on distribution data and selfreported net ownership, but it is important to also assess the goal endpoint of reduction in malaria prevalence. We show that this can be achieved quickly and cost-effectively through randomized surveys measuring bednet usage coupled with malaria prevalence at the household level.

scholarly journals Evaluation of the Effect of Supervised Antimalarial Treatment on P. Vivax Malaria Recurrences

2021 ◽  
Author(s):  
Kelry Mazurega Oliveira Dinelly ◽  
Sheila Vitor-Silva ◽  
Jose Diego Brito-Sousa ◽  
Vanderson Souza Sampaio ◽  
Milena Gabriela Oliveira Silva ◽  
...  
Keyword(s):  
Malaria Control ◽  
Vivax Malaria ◽  
Real Life ◽  
Control Program ◽  
Standard Of Care ◽  
The Real ◽  
Malaria Control Program ◽  
Blood Smears ◽  
National Malaria Control Program ◽  
The Cost

Abstract BackgroundRelapses in vivax malaria have posed great challenges to malaria control, accounting for a great proportion of reported cases. Knowing the real effectiveness of 7 day primaquine (PQ) scheme is crucial to understand not only the cost-effectiveness of implementing new anti-hypnozoite drugs but how health education strategies can guarantee better compliance and be reinforced. This study aimed the evaluation of the daily supervised treatment effect with chloroquine and PQ (in consented patients) versus prescription without supervision (non-consented patients), and the outcome was the passive detection of new positive thick blood smears until 180 days, based on the official data records from the National Malaria Control Program. The recurrences seen in the real life were therefore used as a surrogate for true relapses. Patients under supervised treatment had a lower risk of recurrence until day 180 when compared to the unsupervised treatment (17.9% vs 36.1%; p=0.027). The lack of consent in the non-supervised group (which followed standard of care in the real life) enabled proper comparison, as consent itself could lead to better compliance in this group. Future studies should scale such analysis to different settings in the Brazilian Amazon.

scholarly journals Rapid selection of a pyrethroid metabolic enzyme CYP9K1 by operational malaria control activities

2018 ◽  
Vol 115 (18) ◽  
pp. 4619-4624 ◽  
Author(s):  
John Vontas ◽  
Linda Grigoraki ◽  
John Morgan ◽  
Dimitra Tsakireli ◽  
Godwin Fuseini ◽  
...  
Keyword(s):  
Malaria Control ◽  
Pyrethroid Resistance ◽  
Resistance Mechanism ◽  
Indoor Residual Spraying ◽  
Control Program ◽  
Parasite Prevalence ◽  
Metabolic Enzyme ◽  
Anopheles Coluzzii ◽  
Bioko Island ◽  
Malaria Control Program

Since 2004, indoor residual spraying (IRS) and long-lasting insecticide-impregnated bednets (LLINs) have reduced the malaria parasite prevalence in children on Bioko Island, Equatorial Guinea, from 45% to 12%. After target site-based (knockdown resistance; kdr) pyrethroid resistance was detected in 2004 in Anopheles coluzzii (formerly known as the M form of the Anopheles gambiae complex), the carbamate bendiocarb was introduced. Subsequent analysis showed that kdr alone was not operationally significant, so pyrethroid-based IRS was successfully reintroduced in 2012. In 2007 and 2014–2015, mass distribution of new pyrethroid LLINs was undertaken to increase the net coverage levels. The combined selection pressure of IRS and LLINs resulted in an increase in the frequency of pyrethroid resistance in 2015. In addition to a significant increase in kdr frequency, an additional metabolic pyrethroid resistance mechanism had been selected. Increased metabolism of the pyrethroid deltamethrin was linked with up-regulation of the cytochrome P450 CYP9K1. The increase in resistance prompted a reversion to bendiocarb IRS in 2016 to avoid a resurgence of malaria, in line with the national Malaria Control Program plan.

scholarly journals Therapeutic efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali, 2015–2016

2020 ◽  
Author(s):  
Youssouf Diarra ◽  
Oumar Koné ◽  
Lansana Sangaré ◽  
Lassina Doumbia ◽  
Dade Bouye Ben Haidara ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Uncomplicated Malaria ◽  
Artemisinin Resistance ◽  
Control Program ◽  
Plasmodium Falciparum Malaria ◽  
Malaria Control Program ◽  
National Malaria Control Program ◽  
Pre Treatment ◽  
Better Than

Abstract Background The current first-line treatments for uncomplicated malaria recommended by the National Malaria Control Program in Mali are artemether–lumefantrine (AL) and artesunate–amodiaquine (ASAQ). From 2015–2016, we conducted an in vivo study to assess the clinical and parasitological responses to AL and ASAQ in Sélingué, Mali. Methods Children between 6 and 59 months of age with uncomplicated Plasmodium falciparum infection and 2,000–200,000 asexual parasites/µL of blood were enrolled, randomly assigned to either AL or ASAQ, and followed up for 42 days. Uncorrected and PCR-corrected efficacy results at days 28 and 42 were calculated. Known markers of resistance in the Pfk13, Pfmdr1, and Pfcrt genes were assessed using Sanger sequencing. Results A total of 449 patients were enrolled: 225 in the AL group and 224 in the ASAQ group. Uncorrected efficacy at day 28 was 83.4% (95% CI: 78.5–88.4%) in the AL arm and 93.1% (95% CI: 89.7–96.5%) in the ASAQ arm. The per protocol PCR-corrected efficacy at day 28 was 91.0% (86.0–95.9%) in the AL arm and 97.1% (93.6–100%) in the ASAQ arm. ASAQ was significantly (p < 0.05) better than AL for each of the aforementioned efficacy outcomes. No mutations associated with artemisinin resistance were identified in the Pfk13 gene. Overall, for Pfmdr1, the N86 allele and the NFD haplotype were the most common. The NFD haplotype was significantly more prevalent in the post-treatment than in the pre-treatment isolates in the AL arm (p < 0.01) but not in the ASAQ arm. For Pfcrt, the CVIET haplotype was the most common. Conclusions Our findings indicate that both AL and ASAQ remain effective for the treatment of uncomplicated malaria in Sélingué, Mali.

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