scholarly journals Characterization and Histological Examination of a Rare Giant Cell Glioblastoma

Cureus ◽  
2020 ◽  
Author(s):  
Sriya V Reddy ◽  
Anna E Kaiser ◽  
Francis J Liuzzi
Keyword(s):  
Giant Cell ◽  
Histological Examination ◽  
Giant Cell Glioblastoma

Recurrent Giant Cell Glioblastoma with the Neuroradiologic Picture of Multiple Meningiomas

2012 ◽  
Vol 74 (02) ◽  
pp. 116-119
Author(s):  
D. Schulz ◽  
F. Wanis ◽  
C. Zuehlke ◽  
A. Schaenzer ◽  
P. Christophis ◽  
...  
Keyword(s):  
Giant Cell ◽  
Multiple Meningiomas ◽  
Giant Cell Glioblastoma

scholarly journals Childhood Giant Cell Glioblastoma

2020 ◽  
Author(s):  
Keyword(s):  
Giant Cell ◽  
Giant Cell Glioblastoma

Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection

2013 ◽  
Vol 29 (8) ◽  
pp. 1387-1390 ◽  
Author(s):  
María Sol Brassesco ◽  
Luiz Guilherme Darrigo ◽  
Elvis Terci Valera ◽  
Ricardo Santos Oliveira ◽  
Yulie Aparecida Yamamoto ◽  
...  
Keyword(s):  
Giant Cell ◽  
Jc Virus ◽  
Hiv 1 ◽  
Giant Cell Glioblastoma

Polymyalgia rheumatica and temporal arteritis

2010 ◽  
pp. 3678-3683
Author(s):  
Jan Tore Gran
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Histological Examination ◽  
Polymyalgia Rheumatica ◽  
Temporal Arteritis ◽  
Superficial Temporal Artery ◽  
Granulomatous Inflammation ◽  
Temporal Artery ◽  
Unknown Aetiology ◽  
Inflammatory Conditions

Polymyalgia rheumatica and temporal arteritis are distinct but overlapping inflammatory conditions of unknown aetiology. They almost exclusively affect people over 50 years of age, women more than men (ratio 2–3:1), and particularly those of Nordic heritage. Temporal arteritis is characterized by granulomatous inflammation that penetrates all layers of the wall of medium and (often) large muscular arteries, in particular the superficial temporal artery. Histological examination of tissues from patients with polymyalgia rheumatica shows nonspecific changes only. The term ‘giant cell arteritis’ is properly used only to describe patients with biopsy-proven arteritis....

63. Near-haploidization molecularly defines giant cell glioblastoma

2020 ◽  
Vol 244 ◽  
pp. 24
Author(s):  
Daynna Wolff ◽  
Jay Alden ◽  
Tiffany Baker ◽  
Cynthia Welsh ◽  
Iya Znoyko ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Glioblastoma

scholarly journals Aggressive giant cell glioblastoma with negative p53 expression: case report

2012 ◽  
Vol 31 (03) ◽  
pp. 163-165
Author(s):  
Marcelo Viana Rodrigues da Cunha ◽  
Julia Keith ◽  
Leodante Batista da Costa
Keyword(s):  
Brain Tumor ◽  
Case Report ◽  
Giant Cell ◽  
Survival Rates ◽  
Surgical Excision ◽  
P53 Mutation ◽  
P53 Expression ◽  
Younger Patients ◽  
Genetic Features ◽  
Giant Cell Glioblastoma

AbstractGlioblastoma (GBM) is the most common intrinsic brain tumor in adults, accounting for 67% of primary brain tumors. Giant cell glioblastoma (GCG) is a rare variation of GBM, occurring in less than 5% of the cases. GCG has been demonstrated to affect younger patients and have a more indolent course than traditional GBM with longer survival rates. Age, surgical resection, and genetic features are likely related with better prognosis. The presence of a p53 mutation is found in 75% of GCG with this more indolent behavior. We present a case of a 72 years-old female who presented with an extremely aggressive GCG without p53 expression who had an unusually rapid neurological deterioration and tumor regrowth after surgical excision.

scholarly journals Giant cell glioblastoma: review of the literature and illustrated case

Neurocirugía ◽  
2008 ◽  
Vol 19 (4) ◽  
pp. 343-349 ◽  
Author(s):  
J.M. Valle-Folgueral ◽  
L. Mascarenhas ◽  
J.A. Costa ◽  
C. Alegria ◽  
F. Vieira ◽  
...  
Keyword(s):  
Giant Cell ◽  
Review Of The Literature ◽  
Giant Cell Glioblastoma

scholarly journals Giant cell glioblastoma in 6‐year‐old kid: Report of an unusual case

2020 ◽  
Vol 8 (12) ◽  
pp. 2936-2940
Author(s):  
Suraj Shrestha ◽  
Sushan Homagain ◽  
Akash Raut ◽  
Gopal Sedhain ◽  
Suraj Bhatta ◽  
...  
Keyword(s):  
Giant Cell ◽  
Unusual Case ◽  
Giant Cell Glioblastoma

scholarly journals Giant cell glioblastoma is a distinctive subtype of glioma characterized by vulnerability to DNA damage

2019 ◽  
Vol 37 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Kaoru Ogawa ◽  
Akira Kurose ◽  
Akihisa Kamataki ◽  
Kenichiro Asano ◽  
Kosuke Katayama ◽  
...  
Keyword(s):  
Dna Damage ◽  
Giant Cell ◽  
Small Cells ◽  
Wild Type ◽  
Dna Double Strand Breaks ◽  
Proliferating Cells ◽  
Strand Breaks ◽  
Mitotic Slippage ◽  
Minimal Invasion ◽  
Giant Cell Glioblastoma

Abstract Giant cell glioblastoma (GC-GBM) consists of large cells with pleomorphic nuclei. As a contrast to GC-GBM, we defined monotonous small GBM (MS-GBM) as GBM that consists of small cells with monotonous small nuclei, and compared the DNA damage as well as other pathological features. GC-GBM showed minimal invasion (< 2 mm) and focal sarcomatous areas. TERTp was wild type in GC-GBM but mutant in MS-GBM. OLIG2 expression was significantly higher in MS-GBM (P < 0.01) (77% in MS-GBM and 7% in GC-GBM). GC-GBM showed significantly higher DNA double-strand breaks (DSBs) compared with MS-GBM (P < 0.01) (76% in GC-GBM and 15% in MS-GBM). Nearly, all large cells in GC-GBM underwent DSBs. Thus, significant DSBs in GC-GBM might be induced by an innate lesser stemness characteristic and be followed by mitotic slippage, resulting in polyploidization and the large pleomorphic nuclei. We conclude that GC-GBM is a distinctive subtype of glioma characterized by its vulnerability to DNA damage and that wild-type TERTp and lower OLIG2 function might induce this feature. Notably, even large pleomorphic nuclei with severe DSBs demonstrated Ki67 positivity, which alerts pathologists to the interpretation of Ki67 positivity, because cells with large nuclei undergoing severe DSBs cannot be recognized as proliferating cells that contribute to tumor aggressiveness.

Favorable outcome of giant cell glioblastoma in a child Report of an 11-year survival period

1998 ◽  
Vol 14 (6) ◽  
pp. 288-291 ◽  
Author(s):  
Rüdiger Klein ◽  
Gabriele Mölenkamp ◽  
Niels Sörensen ◽  
Wolfgang Roggendorf
Keyword(s):  
Giant Cell ◽  
Favorable Outcome ◽  
Survival Period ◽  
Child Report ◽  
Giant Cell Glioblastoma
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