Mimicker of Renal Cell Carcinoma- A Case Report

Oncocytoma is a rare epithelial tumour composed of oncocytes which are epithelial cells with excessive amount of mitochondria. The tumour is most often benign, and diagnosis can be made on the basis of histopathological examination. Here, the authors present a 64-year-old female patient, with complaints of abdominal discomfort and flank pain, along with history of loss of weight and appetite for one month. Radiology showed a left renal mass of measuring 9×7×4.5 cm involving the upper and middle pole suggestive of malignancy. Following which radical nephrectomy was done. Examination of gross specimen showed a fairly circumscribed brownish lesion in the upper and middle pole of left kidney measuring 8.8×7×4.5 cm with a central scar. There was no evidence of hilar and perirenal fat invasion. Histology showed sheets of large polygonal eosinophilic cells with centrally placed nucleus. The differentials were eosinophilic variant of clear cell renal cell carcinoma, chromophobe renal cell carcinoma and oncocytoma. A panel of Immunohistochemical (IHC) markers was performed for further categorisation and the lesional cells were positive for CD 117 and negative for CD 7 and CD 10. This ruled out the differentials and confirmed oncocytoma, thus ruling out the necessity for chemotherapy.

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Ovarian metastasis of clear cell renal cell carcinoma: A case report

Canadian Urological Association Journal ◽

10.5489/cuaj.1456 ◽

2014 ◽

Vol 8 (3-4) ◽

pp. 188 ◽

Cited By ~ 4

Author(s):

Lenka Bauerová ◽

Pavel Dundr ◽

Daniela Fischerová ◽

Michal Pešl ◽

Michal Zikán ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Left Kidney ◽

Progesterone Receptors ◽

Ovarian Tumour ◽

Tumour Mass ◽

Cell Renal Cell Carcinoma ◽

History Of

We report on a 61-year-old woman with a history of right-sided nephrectomy for clear cell renal cell carcinoma (RCC) occurring 21 years ago; she currently presented with a bilateral ovarian tumour. Histologically, the tumour of both ovaries was clear cell carcinoma. Immunohistochemically, the tumour cells were positive for vimentin, RCC marker, epithelial membrane antigen, cytokeratin AE1/3 and CD10. Cytokeratin 7, CA125, HMWCK, estrogen and progesterone receptors were all negative. Based on the morphologyand immunophenotype of the tumour, we established a diagnosis of late metastasis of RCC in the ovaries. A postoperative abdominal computed tomography scan, however, revealed a tumour mass solely in the left kidney, which had not been visible in the preoperative ultrasound. The patient underwent nephron-sparing surgery and a biopsy showed the tumour to be clear cell RCC. Metastasis of RCC to the ovaries is rare, and to the best of our knowledge, only 24 cases have been reported to date. However, due to the different treatments and prognosis, the distinction between a primary ovarian tumour and metastasis of RCC is important.

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Primary hydatid cyst looked like renal cell carcinoma: case report

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa231 ◽

2020 ◽

Vol 2020 (9) ◽

Author(s):

Irzi Mohamed ◽

Mhanna Tarik ◽

Aynaou Mohammed ◽

Wassim Alaoui ◽

Ouraghi Abdelghani ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Hydatid Cyst ◽

Cell Carcinoma ◽

Renal Cell ◽

Histopathological Examination ◽

Left Kidney ◽

Developed Countries ◽

History Of ◽

Primary Hydatid Cyst ◽

Renal Cell Carcinoma Case

Abstract Renal hydatid cyst is a rare disease comprising of about 2–3% of all locations. We present a case of renal hydatid disease in a 48-year-old female patient who presented with a history of left flank pain without fever or hematuria. Ultrasonography and computed tomography showed a 3-cm cystic lesion Bosniak IV occupying the mid-zone of the left kidney diagnosed as renal malignancy. Laparoscopic partial nephrectomy was performed, but the histopathological examination of the lesion revealed hydatid cysts. Isolated renal hydatid cyst is very rare, especially in developed countries and can be misdiagnosed as a renal cell carcinoma pre-operatively.

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Non-osseous soft tissue metastasis in the foot from renal cell carcinoma

BMJ Case Reports ◽

10.1136/bcr-2020-236051 ◽

2020 ◽

Vol 13 (10) ◽

pp. e236051

Author(s):

Nusrat Jahan ◽

Shabnam Rehman

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Soft Tissues ◽

Imaging Techniques ◽

Musculoskeletal Symptoms ◽

Systematic Evaluation ◽

Pathological Examination ◽

Cell Renal Cell Carcinoma ◽

History Of

Metastatic tumours of the distal extremities, also known as acrometastases, are rare. The majority of the acrometastases involve bones—involvement of the soft tissues of the feet and hands is extremely rare. We report a case of clear cell renal cell carcinoma metastasised to the soft tissues of the foot. The patient presented with pain and swelling in his right foot. Diagnosis of acrometastases frequently gets delayed due to the rarity of this condition and resultant low clinical suspicion. Possibility of metastatic disease should be entertained as an important differential diagnosis when patients with a history of cancer present with musculoskeletal symptoms. A systematic evaluation incorporating thorough clinical assessment, advanced imaging techniques like MRI and pathological examination is critical to establish the diagnosis.

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A Rare Case of the Simultaneous, Multifocal, Metastatic Renal Cell Carcinoma to the Ipsilateral Left Testes, Bladder, and Stomach

Case Reports in Urology ◽

10.1155/2016/1829025 ◽

2016 ◽

Vol 2016 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Michael Kongnyuy ◽

Samuel Lawindy ◽

Daniel Martinez ◽

Justin Parker ◽

Mary Hall

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Simultaneous Presentation ◽

Cell Renal Cell Carcinoma ◽

Diagnostic Endoscopy ◽

Surveillance Imaging ◽

History Of

We describe the rare case of a 68-year-old gentleman with the history of a hand-assisted laparoscopic left radical nephrectomy for a T2bN0M1 clear cell renal cell carcinoma (RCC). Seven years after surgery and with clean surveillance imaging for metastasis/recurrence the patient presented with three separate tumors suspicious for malignancy. A bladder lesion was found during workup for hematuria, a stomach lesion during diagnostic endoscopy, and a testicular lesion during self-exam. He underwent transurethral resection of bladder tumor, left inguinal orchiectomy, and upper endoscopic ensnarement. All specimens surprisingly showed RCC by histology and immunostaining. These three sites are rare for RCC metastasis and simultaneous presentation is even rarer, further emphasizing the importance of continuous and careful follow-up in this patient population, despite what could appear as complete remission.

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Metastatic renal cell carcinoma in the head and neck region

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20182721 ◽

2018 ◽

Vol 4 (4) ◽

pp. 1092

Author(s):

Sowjanya Gandla ◽

Veena Ramaswamy ◽

Vishal Rao

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Left Kidney ◽

Neck Region ◽

Temporal Region ◽

Head And Neck Region ◽

History Of ◽

Left Temporal Region

<p>We describe 3 rare cases of metastatic renal cell carcinoma in the head and neck region. Our first case was a 72 years old male presented with profuse bleeding from the left ear. On examination, proliferative, pink, friable mass was present in the left external auditory canal. On eliciting the detailed history, it was found that patient had renal cell carcinoma in the left kidney four years back and underwent left radical nephrectomy. Patient underwent left lateral temporal bone resection with cul-de-sac closure. Histopathological examination of the specimen showed metastatic renal cell carcinoma. Our second case was a 64 years old male presented with complaints of growth in the oral cavity of 1 month duration. On examination, 5×3 cms proliferative growth was present in the hard palate. Biopsy from the growth in the hard palate showed metastatic renal cell carcinoma. Patient gave history of renal cell carcinoma in the past for which he did not receive treatment. Our third case was a 45 years old male who presented to us with a diffuse swelling in the left temporal region of 2 months duration. On examination, 3×2 cms swelling was present in the left temporal region. Patient had history of renal cell carcinoma of left kidney and underwent left nephrectomy one year prior to the presentation of the left temporal swelling. Ultrasonography guided biopsy of the left temporal region showed metastatic renal cell carcinoma.</p>

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A case of Synchronous Malignancy of Stomach and Kidney

Kathmandu University Medical Journal ◽

10.3126/kumj.v11i1.11053 ◽

2014 ◽

Vol 11 (1) ◽

pp. 94-95 ◽

Cited By ~ 1

Author(s):

S SM Aslam ◽

H Sridhar ◽

MY Rao

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Left Kidney ◽

Poorly Differentiated Adenocarcinoma ◽

Primary Renal Cell Carcinoma ◽

History Of ◽

Poorly Differentiated ◽

Polypoidal Growth ◽

Synchronous Malignancy

The synchronous occurrence of primary renal cell carcinoma with gastric cancer is very rare. We report a case of 41 year old male who presented on 05/07/2011 to M S Ramaiah hospital, Bangalore with history of fever, pain abdomen and malena. Ultrasound abdomen and pelvis showed large heterogenous mass arising from the upper pole of left kidney. Computed tomography of the abdomen showed left renal cell carcinoma. Renal biopsy showed features consistent with renal cell carcinoma – clear cell type. Oesophagogastroduodenoscopy revealed gastric polypoidal growth. Gastric biopsy from the growth revealed poorly differentiated adenocarcinoma of stomach. We report this case to highlight a rare occurrence of synchronous malignancy of stomach and kidney. DOI: http://dx.doi.org/10.3126/kumj.v11i1.11053 Kathmandu University Medical Journal Vol.11(1) 2013: 94-95

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Rare case of clear cell renal cell carcinoma presenting as a unilateral tonsil lesion

BMJ Case Reports ◽

10.1136/bcr-2020-237941 ◽

2020 ◽

Vol 13 (12) ◽

pp. e237941

Author(s):

Shawn David Ellis ◽

Alison Meikle ◽

Wassim Al-Salti ◽

Georges Sinclair

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Kinase Inhibitor ◽

Lung Metastases ◽

Cell Cancer ◽

Rare Presentation ◽

Cell Renal Cell Carcinoma ◽

History Of ◽

Diagnosis Of Cancer

A 70-year-old man presented with gradually worsening throat discomfort. He had no prior diagnosis of cancer and no travel history of note. Examination revealed a right-sided painless neck lump. He underwent an MRI of the neck, revealing a gadolinium-enhancing tonsillar mass and two brain lesions. Biopsy of the tonsil lesion was in keeping with an epithelial neoplasm, suggesting metastatic renal cell carcinoma. This was confirmed following a staging CT, which revealed a left renal mass and lung metastases. Due to his brain metastases, the patient has been started on the tyrosine kinase inhibitor cabozantinib. A brief discussion on the diagnostic evaluation of a tonsil mass as a rare presentation of renal cell cancer follows this report.

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Paraneoplastic limbic encephalitis cured with nephron-sparing surgery in a patient with clear cell renal cell carcinoma: a case report

Journal of International Medical Research ◽

10.1177/0300060519863524 ◽

2019 ◽

Vol 47 (10) ◽

pp. 5318-5322

Author(s):

Lunfeng Zhu ◽

Xiaolin Deng ◽

Zhaohui Lai ◽

Ning Xie ◽

Wanlong Tan

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Clear Cell ◽

Limbic Encephalitis ◽

Nephron Sparing Surgery ◽

Cell Renal Cell Carcinoma ◽

Paraneoplastic Limbic Encephalitis ◽

Nephron Sparing ◽

History Of

Paraneoplastic limbic encephalitis (PLE) in association with clear cell renal cell carcinoma has never been reported in China. We herein describe a 54-year-old man with a 1-week history of headache and a 3-day history of psychiatric symptoms. Slight nuchal rigidity was found by physical examination. Imaging studies of the head were normal. Blood and cerebrospinal fluid antibody testing were both positive for N-methyl-D-aspartic acid antibodies. Subsequent contrast-enhanced computed tomography revealed a 5.2- × 4.2-cm left kidney mass with intense enhancement. Emergent laparoscopic nephron-sparing surgery was successfully performed. Immunohistochemistry revealed clear cell renal cell carcinoma. The patient’s status improved after the surgery, and he was discharged after 1 month of hospitalization. At the 6-month follow-up, magnetic resonance imaging showed no recurrence, and the patient was living independently. This case indicates the potential effect of nephron-sparing surgery in the treatment of PLE. Tumor screening should be performed early in patients with suspected PLE. Early surgical resection of the primary tumor can improve patients’ prognosis.

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Rare Case of Clear Cell Renal Cell Carcinoma Metastasizing to Contralateral Kidney and Ipsilateral Parotid more than five Years following Nephrectomy

Balkan Journal of Dental Medicine ◽

10.2478/bjdm-2019-0020 ◽

2019 ◽

Vol 23 (2) ◽

pp. 108-111

Author(s):

Guy Sydney ◽

Kalliopi Ioakim ◽

Nayia Kara ◽

George Pantelas

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Rare Case ◽

Clear Cell ◽

Histopathological Diagnosis ◽

Cell Renal Cell Carcinoma ◽

Contralateral Kidney ◽

History Of ◽

Patient’S History

Summary Backgroung/Aim: Salivary gland malignancies are rare, with only a fraction due to metastases. We report a rare case of the Clear Cell Renal Cell Carcinoma (CCRCC), a subtype of the Renal Cell Carcinoma (RCC), metastasizing to the parotid gland more than five years following nephrectomy. Case report: A 75-year-old female presented with a unilateral left parotid mass that was growing over the period of 18 months. After clinical and laboratory examinations, the patient underwent left partial superficial parotidectomy with preservation of the facial nerve. The significance of the patient’s history of the CCRCC was pivotal to the histopathological diagnosis of a metastatic CCRCC to the parotid. Conclusions: The unpredictable nature of the RCC results in the need for a long period of follow-up, as well as having a high degree of suspicion of metastasis in a patient presenting with a medical history of the RCC and a parotid mass.

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