Detection of Helicobacter pylori in Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders at a Tertiary Care Centre in Gujarat: A Case-Control Study

Introduction: Oral squamous cell carcinoma (OSCC) contribute to 90% of cancer cases in head and neck region and entails remarkable morbidity and mortality inspite of immense research and advances. Amongst other causes, infection with Helicobacter pylori is an emerging cause of OSCC. There is still perplexity in the exact etiopathogenesis of H. pylori related oral cancer. Aim: In order to explore this much unattended area, present study was aimed to find out the association between H. pylori in premalignant disorders and OSCC. Materials and methods: A Prospective case-control Pilot study of 35 patients (11 confirmed cases of Oral squamous cell carcinoma and 24 with oral potentially malignant disorders along with 15 age and sex matched healthy control) from June 2018 - September 2018 was conducted in the Department of Microbiology, Smt. B. K. Shah Medical Institute, Piparia, Gujarat. H. pylori was detected by methods like Rapid urease test, Gram’s staining and Serology. Results: H. pylori was detected in five cases with OSCC with male predominance and mean age 45.6 yrs. All the five positive patients were severely addicted to tobacco and betel quid since decades. Tobacco was found to be the major risk of OSCC with the OD of 16.19, followed by betel quid (OD-4.56) and H. pylori infection (OD-0.83). Conclusion: The results of this pilot study do not establish a definite causal relationship between H. pylori and OSCC due to the low sample size. Study definitely offers an avenue for further work on larger populations to confirm this possible association.

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Association of Helicobacter pylori with oral potentially malignant disorders and oral squamous cell carcinoma—a systematic review and meta-analysis

Clinical Oral Investigations ◽

10.1007/s00784-019-03125-2 ◽

2019 ◽

Vol 24 (1) ◽

pp. 13-23 ◽

Cited By ~ 2

Author(s):

Archana A. Gupta ◽

Supriya Kheur ◽

A. Thirumal Raj ◽

Pratiksha Mahajan

Keyword(s):

Systematic Review ◽

Squamous Cell Carcinoma ◽

Helicobacter Pylori ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Meta Analysis ◽

Oral Potentially Malignant Disorders ◽

Potentially Malignant Disorders ◽

Potentially Malignant

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Evaluation of Prevalence of Bacteria Helicobacter pylori in Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1319 ◽

2015 ◽

Vol 6 (2) ◽

pp. 82-86 ◽

Cited By ~ 1

Author(s):

Minal Chaudhary ◽

Madhuri Gawande ◽

Preethi Sharma

Keyword(s):

Squamous Cell Carcinoma ◽

Helicobacter Pylori ◽

Oral Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Bacterial Species ◽

Potentially Malignant Disorders ◽

Potentially Malignant ◽

H Pylori

ABSTRACT Cancer is a complex disease that is variable in its presentation, development and outcome. The same heterogeneity and variability exist at the cellular and molecular level. Cancer is a multistep process during which cells undergo intense metabolic and behavioral changes, leading them to proliferate in an extreme and early way to escape supervision by the immune system and ultimately invades distant tissues to form metastases. Globally, almost 20% of cancers are related to infectious agents. Several viruses with oncogenic potential stimulate cell proliferation leading to cancer in animals and humans. Viruses, in particular, have been found to play a major role in the process of cancer involving several organs. Bacterial species related with cancer etiology are varied; however, the infections they cause have common characteristics. The association between Helicobacter pylori and gastric carcinoma is well established but the association between H. pylori and oral squamous cell carcinoma (OSCC) is not evident. Studies have also reported the existence of H. pylori in the oral cavity, but whether the oral cavity serves as an extra gastric source for H. pylori or carries the organism only transiently is debatable. Hence, with this aim in the mind, we conducted the present study to evaluate the incidence of H. pylori in premalignant disorders and OSCC. How to cite this article Sharma P, Gawande M, Chaudhary M. Evaluation of Prevalence of Bacteria Helicobacter pylori in Potentially Malignant Disorders and Oral Squamous Cell Carcinoma. World J Dent 2015;6(2):82-86.

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