Feasibility, Safety, and Efficacy of Accurate Uterine Fibroid Ablation Using Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound With Shot Sonication

2015 ◽  
Vol 34 (12) ◽  
pp. 2293-2303 ◽  
Author(s):  
Yonghua Xu ◽  
Zhongxiang Fu ◽  
Lixia Yang ◽  
Zili Huang ◽  
Wen-Zhi Chen ◽  
...  
2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 339-339 ◽  
Author(s):  
Jin Il Kim ◽  
DaeYoung Cheung

339 Background: The aim of this study was to evaluate safety and efficacy of high-intensity focused ultrasound (HIFU) for advanced pancreatic cancer. Methods: Patients with pancreatic cancer TNM stage III or IV were included. Magnetic resonance imaging was performed 2 weeks before and after the HIFU. The ablating tumor volume was calculated by ratio of the non-perfused necrotic area of the planned area on contrast-enhanced T1-weighted image on post-HIFU magnetic resonance imaging. The ablation results were stratified into 4 ranges: 100% to 90% unenhanced area of targeting area, 90% to 50%, within 50%, and no change. Results: High-intensity focused ultrasound treatment was performed without severe adverse event in 52 patients, 53 times (male/female = 28/24; mean age, 62.7 ± 12.1; TNM stage 3/stage 4 = 21/31). Average size of the pancreatic cancer lesion was 4.5 ± 1.6 cm (1.4 - 9.5 cm). After HIFU treatment, ablating tumor volume was as follows: 90% to 100% in 41 lesions, 90% to 50% in 11, and within 50% in 3. Overall median survival (S1) from initial pancreatic cancer diagnosis was 13.1 months. Overall survival (S2) rates at 6, 12, and 18 months from HIFU were 53.1%, 31.6%, and 23.5%, respectively, with a median survival of 7.4 months. Conclusions: High-intensity focused ultrasound is safe and effective, which induced excellent local tumor control in most patients with advanced pancreatic cancer.


2018 ◽  
Vol 27 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Karun V. Sharma ◽  
Pavel S. Yarmolenko ◽  
Avinash Eranki ◽  
Ari Partanen ◽  
Haydar Celik ◽  
...  

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