Hour-Specific Total Serum Bilirubin Percentiles for Infants Born at 29–35 Weeks’ Gestation

<b><i>Introduction:</i></b> As preterm infants are susceptible to hyperbilirubinemia, they require frequent close monitoring. Prior to initiation of phototherapy, hour-specific total serum bilirubin (TSB) percentile cut-points are lacking in these infants, which led to the current study. <b><i>Methods:</i></b> A multi-site retrospective cohort study of preterm infants born between January 2013 and June 2017 was completed at 3 NICUs in Ontario, Canada. A total of 2,549 infants born at 29^0/7–35^6/7 weeks’ gestation contributed 6,143 pre-treatment TSB levels. Hour-specific TSB percentiles were generated using quantile regression, further described by degree of prematurity, and among those who subsequently received phototherapy. <b><i>Results:</i></b> Among all infants, at birth, hour-specific pre-treatment, TSB percentiles were 36.1 µmol/L (95% confidence interval [CI]: 34.3–39.3) at the 40th, 52.3 µmol/L (49.4–55.1) at the 75th, and 79.5 µmol/L (72.1–89.6) at the 95th percentiles. The corresponding percentiles were 39.3 μmol/L (35.9–43.2), 55.4 μmol/L (52.1–60.2), and 87.1 μmol/L (CI 70.5–102.4) prior to initiating phototherapy and 24.4 μmol/L (20.4–28.8), 35.3 μmol/L (31.1–41.5), and 52.0 μmol/L (46.1–62.4) among those who did not receive phototherapy. Among infants born at 29–32 weeks, pre-treatment TSB percentiles were 53.9 µmol/L (49.4–61.0) and 95.5 µmol/L (77.5–105.0) at the 75th and 95th percentiles, with respective values of 48.7 µmol/L (43.0–52.3), and 74.1 µmol/L (64.8–83.2) for those born at 33–35 weeks’ gestation. <b><i>Conclusion:</i></b> Hour-specific TSB percentiles, derived from a novel nomogram, may inform how bilirubin is described in preterm newborns. Further research of pre-treatment TSB levels is required before clinical consideration.

A Transcanal Endoscopic Approach for Management of Pulsatile Tinnitus due to High-Riding Dehiscent Jugular Bulb

Pulsatile tinnitus (PT) caused by a high-riding dehiscence jugular bulb (HDJB) is a rare but treatable otology disease. There are several managements include transcatheter endovascular coil embolization, transvenous stent–assisted coil embolization, or resurfacing the dehiscent bony wall of high jugular bulb under the use of microscope. Among those options, surgical resurfacing of HDJB might be an effective and safe choice with less destruction. However, previous studies approached middle ear cavity via microscope can only provide a lateral, indirect view, while resurfacing the vessel through a transcanal endoscopic ear surgery (TEES) approach may give surgeon a direct and easy way to manage HDJB. In this report, we presented a case of 40-year-old woman with HDJB and shared our clinical consideration and reasoning of the surgical management of PT via a transtympanic approach by TEES rather than a transmastoid approach.

Pharmacogenetic Testing in an Academic Psychiatric Clinic: A Retrospective Chart Review

Pharmacogenomic (PGx) testing is being increasingly recognized by clinicians as an essential tool to guide medication decisions for treatment of psychiatric illnesses. Extensive implementation of PGx testing, however, varies by setting and location. In this retrospective study, we reviewed charts from 592 patients diagnosed with a psychiatric disorder at the Loyola University Medical Center, for whom PGx testing was performed. Information collected included demographics at the time of testing, psychiatric diagnosis, medical and psychiatric history and medications prior and after PGx testing. Of the 592 charts analyzed, the most common primary diagnoses were depression (52%) and anxiety (12%). Prior to PGx testing, 72% of patients were prescribed three or more medications, whereas, after testing, only 44% were prescribed three or more medications included in the test panel (p < 0.0001). The most common clinical consideration on the PGx reports was recommendation to reduce dosages (33%). After PGx testing, the proportion of patients taking incongruent medications decreased from 26% to 19% and that of patients taking congruent medications increased from 74% to 81% (p = 0.006). The results from this retrospective data analysis demonstrated a reduction in polypharmacy and an increase in recommendation-congruent medication prescribing resulting from implementation of PGx testing.

Non-medical Factors Affecting the Decision of Caesarean: A Study through Path Analysis

When life-threatening conditions occur during pregnancy or childbirth, Caesarean section (CS) is among the most important procedures for protecting the lives of mothers and babies [1]. Non-medical causes have been proposed as primary contributors to excessive CS [2]. Over the last few decades, global CS concentrations have gradually increased [3]. Aside from the potential for negative health consequences, unnecessary CS places a significant financial burden on individuals, families, and society as a whole. The expenditure of post-pregnancy clinical consideration and cross as a result of prolonged CS is projected to be around US$ 2.32 billion globally. The expenditure of post-pregnancy clinical consideration and cross as a result of prolonged CS is projected to be around US$ 2.32 billion globally. We looked at variables like education, occupation, wealth index, respondent’s media exposure, and child alive in this project, all of which have a major causal association with our dependent variable CS delivery. Based on the BDHS 2017-18 data, we used path analysis to look at the cultural and racial factors that influence the choice of CS in Bangladesh. For this, we used the SPSS AMOS program. Aside from binary logistic analysis, multivariate analysis was performed. Furthermore, correlation was used to identify the variables that had the greatest impact on the choice of CS.

Activity Recognition using Accelerometer Sensor and Machine Learning Classifiers

Development affirmation is considered as a huge endeavor in various applications, particularly in clinical consideration organizations. Among these applications consolidate clinical decisive, seeing of customers' consistently timetable and ID of unusual cases. Here we present an approach for the development affirmation using an accelerometer sensor embedded in a mobile phone. This strategy uses a transparently available accelerometer dataset as the unrefined information signal. The features of the sign are picked subject to the time and repeat space. By then, Principal Component Analysis (PCA) is used to diminish the dimensionality of the features and concentrate the primary ones that can describe human activities. An assessment collaboration is performed between the primary unrefined data and PCA-based features and moreover, time and repeat region features are similarly contemplated using a couple of AI classifiers. The got results show that the PCA-based features get higher affirmation rate while repeat region features have higher exactness, with the speed of 96.11% and 92.10% independently.

Zirconia Over Titanium Implants: The Evidences are not Enough

Implant therapy is a widely used treatment modality for completely and partially edentulous patient. It gives excellent long term results and has made practice of dental implantology astonishingly widespread. Titanium dental implants have proved to be successful means of prosthetic rehabilitation for more than six decades. Recently, ceramics have been proposed as an alternative to titanium. Zirconia implants with better aesthetics, mechanical and biological properties are showing a promising future in dental implantology. This narrative review analyses the evidences to compare titanium and zirconium implant in a systemic manner. The paper includes the mechanical, biological and clinical consideration involving both implant materials.