scholarly journals FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET USING LOCUST BEAN GUM AS A NATURAL SUPERDISINTEGRANT AND COMPARISON WITH THE MARKETED PREPARATION

2021 ◽  
Vol 15 (5) ◽  
pp. 13-20
Author(s):  
Namrata S Mane ◽  
Namrata A Muddalwar ◽  
Priya V Nikam ◽  
Narendra R Dighade
Keyword(s):  
Dosage Form ◽  
Diclofenac Sodium ◽  
Locust Bean Gum ◽  
Direct Compression ◽  
Compression Method ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Locust Bean ◽  
Ir Study

The aim was to formulate and evaluate fast dissolving tablets of diclofenac sodium to improve the bioavailability of the drug and patient compliance. Fast dissolving tablets of diclofenac sodium were prepared by direct compression method by using superdisintegrants (locust bean gum) in 2%, 3%, 4% 5% & 6% concentration respectively. Tablets were formulated by using natural superdisintegrants locust bean gum (LBG). This formulated mixture i.e., drug and LBG was mixed with other excipients and the tablets were compressed by direct compression. Formulated tablets were characterized by FTIR, pre-compression and post-compression parameters. The In vitro drug release studies were performed in pH 6.8 phosphate buffer. Formulated tablets were characterized by FTIR, the results of IR study showed that there was no interaction between superdisintegrant and pure drug, the results of FTIR study showed that drug was stable in the final formulated tablet. The drug content was evaluated with the help of assay. Five (F1-F5) formulations were evaluated for pre-compression and post-compression parameters and all the results were in the standard limits. Formulated dosage form may be an effective alternative to conventional dosage form which can be effectively used in the treatment of inflammation specially in cases of acute pain.

scholarly journals DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE

2018 ◽  
Vol 8 (5-s) ◽  
pp. 235-239
Author(s):  
NILESH M MAHAJAN ◽  
Kalyanee Wanaskar ◽  
Yogesh Bhutada ◽  
Raju Thenge ◽  
Vaibhav Adhao
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
In Vitro Release ◽  
Matrix Tablet ◽  
Direct Compression ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Tablet Properties ◽  
Vitro Release

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15,  it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for optimize batch was found to 94.62%.  Hence it can be conclude that Nateglinide extended release matrix tablet can prepared by using HPMC. The swollen tablet also maintains its physical integrity during the drug release study Keywords: Tablet, in-vitro drug release, Nateglinide, HPMC

scholarly journals Formulation, Characterisation and Evaluation of the Ethosuximide Oral Immediate Release Tablets

2020 ◽  
Vol 11 (2) ◽  
pp. 1807-1813
Author(s):  
Naga Sujan M ◽  
Kunal K Mehta ◽  
Amit B Patil ◽  
Anusha Vajhala
Keyword(s):  
Drug Release ◽  
Dosage Form ◽  
Immediate Release ◽  
Rice Starch ◽  
Wet Granulation ◽  
Drug Release Profile ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Release Studies

The present study is aimed to formulate, characterization, and evaluate oral immediate-release tablets of Ethosuximide. It is employed as an anti-epileptic agent used in the treatment of epilepsy, in all the age groups who were≥ 1 year. The dosage form is formulated by directly compressing the blend and granulating the powder blend by wet granulation methods. The optimized formulation is achieved by the trial and error method by changing the concentration of lactose monohydrate and di-basic calcium phosphate dehydrate as diluents, sodium starch glycolate as Super-dis-integrant, rice Starch as an intra-granular binder, hydroxypropyl cellulose as binder talc as a lubricant. Evaluation parameters such as micrometric properties, disintegration time along with in-vitro drug release studies were performed for characterizing the dosage form. In-vitro drug release studies were carried out using 0.1 N HCl as dissolution media with 75 rpm and temperature of 370C ± 50C by employing USP apparatus II (Paddle type). Estimation of the % drug release of the tablet was carried out using the UV method. The prepared formulation and the marketed formulation were tested for the in-vitro drug release profile and the prepared formulation was compared with the marketed formulation. All the evaluated result was found to be within the specifications. Therefore, from the obtained evaluation results F6 trail was selected as the best formulation.

scholarly journals Formulation and evaluation of gastro-retentive floating tablets of terbinafine

2020 ◽  
Vol 13 (1) ◽  
pp. 257-266
Author(s):  
Kapil Jalodiya ◽  
Sourabh Jain ◽  
Karunakar Shukla
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Extended Period ◽  
Direct Compression ◽  
Compression Method ◽  
In Vitro Drug Release ◽  
Floating Tablets ◽  
Gastro Retentive

Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. The prepared tablets of terbinafine were evaluated tablet hardness, uniformity of weight, friability, uniformity of content, in vitro buoyancy test, swelling index, in vitro dissolution study and stability study. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chemical interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of terbinafine shown that the formulation F5 was found to be the best formulation as it releases 96.22% terbinafine in a controlled manner for an extended period of time (up to 480 min). The release data was fitted to various mathematical models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. Prepared floating tablets of terbinafine may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.

scholarly journals Formulation development and evaluation of gastroretentive mucoadhesive tablets of glimepiride using natural polymers

2020 ◽  
Vol 10 (4-s) ◽  
pp. 153-159
Author(s):  
Rahul Malasiya ◽  
Tarkeshwar P. Shukla
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Extended Period ◽  
Direct Compression ◽  
Compression Method ◽  
In Vitro Drug Release ◽  
Mucoadhesive Tablets ◽  
Gastro Retentive

Glimepiride, a third-generation sulfonylurea is poorly soluble anti-diabetic drug. Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations as valuable drug excipients. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. The development of mucoadhesive sustained release drug delivery system is recommended in order to enhance the bioavailability. A mucoadhesive tablets were developed using the natural polymer sodium alginate and gum tragacanth. Mucoadhesion is a complex phenomenon which involves wetting, adsorption and interpenetration of polymer chains. The tablets of glimepiride were prepared by direct compression method. Pre-compression parameters were evaluated. The tablets were evaluated for post-compression parameters such as thickness, hardness, average weight, friability and In vitro release studies. All the compositions were resulted in adequate pharmacopoeial limits. The varying concentration of polymers was found to affect on in-vitro drug release and mucoadhesive strength. In vitro drug release of gastro retentive tablet of glimepiride shown that the formulation F5 was found to be the best formulation as it releases 98.78%.  Glimepiride in a sustain release manner for an extended period of time (up to 12 hrs). The release data was fitted to various mathematical models such as higuchi, korsmeyer-peppas, first order and zero order to evaluate the kinetics and mechanism of the drug release. Prepared tablets of glimepiride may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system. Keywords: Glimepiride, Gastro retentive, Anti-diabetic drug, Direct compression method

scholarly journals Hibiscus sabdariffa Mucilage as a Disintegrant in Formulating Fast Dissolving Tablets

2017 ◽  
Vol 15 (2) ◽  
pp. 143-149
Author(s):  
SB Shirsand ◽  
Shivanand ◽  
Shailashri ◽  
GG Keshavshetti ◽  
V Jonathan
Keyword(s):  
Drug Release ◽  
Hibiscus Sabdariffa ◽  
Compression Method ◽  
In Vitro Drug Release ◽  
Basella Alba ◽  
Drug Content ◽  
Release Studies ◽  
Wetting Time ◽  
Mouth Feel

The aim of the present work was to prepare and evaluate fast dissolving tablets of nebivolol with a view to enhance patient compliance and minimize the side effects. In this study, fast dissolving tablets of nebivolol were formulated by direct compression method using mucilages of tapioca seeds (Manihot esculenta), basella climb (Basella alba), red sorrel (Hibiscus sabdariffa) as natural disintegrants and crosspovidone as a synthetic superdisintegrant in different ratios with directly compressible mannitol (Pearlitol SD 200) as a diluent to enhance the mouth feel. The prepared formulations were evaluated for hardness, friability, drug content, in vitro dispersion time, wetting time, water absorption ratio, in vitro drug release, stability and excipients interaction. Among all the formulations, the formulation (FHD3) containing 8% w/w mucilage of Hibiscus sabdariffa was the overall best formulation (t50% 1.7 min) based on in vitro drug release studies. Stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05). From the above studies, it can be concluded that fast dissolving tablets of nebivolol can be prepared using different mucilages as natural disintegrants for faster dispersion and disintegration in the mouth.Dhaka Univ. J. Pharm. Sci. 15(2): 143-149, 2016 (December)

scholarly journals Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate

2013 ◽  
Vol 49 (4) ◽  
pp. 783-792
Author(s):  
Mangesh Machhindranath Satpute ◽  
Nagesh Shivaji Tour
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Direct Compression ◽  
Metoprolol Tartrate ◽  
Compression Method ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Weight Variation ◽  
Wetting Time

The demand for fast dissolving tablets has been growing during the last decade, especially for elderly and children who have swallowing difficulties. In the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including weight variation, hardness, friability, in vitro dispersion time, drug-polymer interaction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR and DSC studies. The tablets prepared by the direct compression method had a weight variation in the range of 145 mg to 152 mg, which is below ± 7.5%, a hardness of 3.6 kg/cm² to 4.5 kg/cm², percentage friability of 0.46% to 0.73%, in vitro dispersion time of 18 s to 125 s, drug content uniformity of between 98.12% and 100.03%, a water absorption ratio of 67% to 87%, wetting time of 32 sec. to 64 sec., and an in vitro drug release of 53.92% - 98.82% within 15 min. The IR spectral analysis and DSC study showed no drug interaction with formulation additives of the tablet, and the formulations indicated no significant changes in hardness, friability, drug content or in vitro drug release. Fast dissolving tablets of metoprolol tartrate have enhanced dissolution and will lead to improved bioavailability and more effective therapy.

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY SYSTEM BY ZAFIRLUKAST

2021 ◽  
pp. 211-220
Author(s):  
N. SHIVA KRISHNA ◽  
B. JAYANTHI ◽  
A. MADHUKAR
Keyword(s):  
Drug Release ◽  
Lag Time ◽  
Early Morning ◽  
Release Profile ◽  
Locust Bean Gum ◽  
In Vitro Drug Release ◽  
The Core ◽  
Locust Bean ◽  
Core Tablet

Objective: The main objective of the present study was to formulate and evaluate a time-controlled single-unit oral pulsatile drug delivery system containing Zafirlukast for the prevention of nocturnal asthma attacks. To provide time-scheduled drug release for Asthma disease. It is used for preventing asthmatic attacks at early morning. Pulsatile release dosage form is increasing patient compliance by reducing the dosing frequency, especially in the early morning. Methods: Core tablets were prepared by incorporating different concentrations of natural and synthetic super disintegrants. Drug-containing core tablets (ZC1-ZC15) with different compositions of natural super disintegrants (Plantago ovata seed powder, Locust bean gum) synthetic super disintegrants (Sodium starch glycolate (SSG), Cross carmellose sodium (CCS), Crospovidone (CP)) were prepared by direct compression technique. The core tablets were subjected to pre-formulation, physicochemical and In vitro drug release studies. The fast disintegrating core tablet formulation was selected and press-coated tablets (P1-P11) were prepared with different compositions of hydrophobic polymers Eudragit RS100, Eudragit RL 100, Ethylcellulose and hydrophilic polymers Hydroxypropyl methylcellulose K4M, K100M. The optimized formulation was selected and quantified based on in vitro drug release profile in simulated gastric and intestinal fluids. Results: The pre and post-compression parameters of tablets were also found to be within limits. Formulation ZC5 with 16 mg of Locust bean gum showed the least disintegrating time, i.e., 22.13 sec, and was selected as the best immediate release core tablet. The press-coated tablet formulation P8 having 62.5 mg Eudragit RS100 and 62.5 mg of HPMC K4M in ratio 1:1 over the core tablet ZC5 showed rapid and drug release nearly after 4 h lag time and 98.86 % up to 12 h. Accelerated stability studies of the optimized formulation P8 indicated no significant difference in release profile after 3 mo. Conclusion: The in vitro dissolution study showed that lag time before drug release was highly affected by the coating amount level and nature of coating polymer used. Time-controlled pulsatile release tablets can be prepared using press-coating techniques.

scholarly journals A NOVEL APPROACH OF LOCUST BEAN GUM MICROSPHERES FOR COLONIC DELIVERY OF MESALAMINE

2018 ◽  
Vol 10 (1) ◽  
pp. 86 ◽  
Author(s):  
V. N.l. Sirisha ◽  
M. Chinna Eswariah ◽  
A. Sambasiva Rao
Keyword(s):  
Drug Release ◽  
Entrapment Efficiency ◽  
Locust Bean Gum ◽  
Ionic Gelation ◽  
Stability Studies ◽  
In Vitro Drug Release ◽  
S 100 ◽  
Locust Bean ◽  
Eudragit S 100

Objective: The objective of the present study was to formulate site-specific drug delivery of mesalamine using Locust bean gum.Methods: The core microspheres were prepared by ionic gelation method using CaCl2 solution and cross-linked with glutaraldehyde and were further coated with pH-sensitive polymer eudragit S-100(1.5-4.5 ml) to retard the drug release in the upper gastrointestinal environment (Stomach and small intestine). Microspheres were characterized by ftir spectroscopy, differential scanning calorimetry and evaluated by scanning electron microscopy (SEM), particle size analysis, entrapment efficiency and in vitro drug release studies in different simulated gastric fluids. Stability studies were carried out for one month at 40±2 °C/75±5% RH.Results: The SEM images revealed the surface morphology was rough and smooth for core and coated microspheres, respectively. The optimized batch (ILBG6) of core microspheres(for 7hr), coated microspheres and coated microspheres in presence of rat caecal contents (8%w/v) for 24hr exhibited 98.44±2.48, 73.58±3.49 % and 98.28±4.42 drug release, respectively. The drug release from all locust bean gum microsphere formulations followed higuchi kinetics. Moreover, drug release from Eudragit S-100 coated microspheres followed the korsmeyer-peppas equation with an fickian kinetics mechanism. Finally, stability studies suggested the change in entrapment efficiency and in vitro drug release of microspheres was minimal, indicating good stability of the formulation.Conclusion: The microspheres formed using natural polysaccharide locust beangum by ionic gelation method are capable of colon targeting the anti-inflammatory drug, mesalamine for the treatment of ulcerative colitis.

scholarly journals FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF BUSPIRONE USING COPROCESSED SUPERDISINTEGRANTS

2019 ◽  
pp. 31-37
Author(s):  
SHALLY SHARMA ◽  
NIMRATA SETH ◽  
NARESH SINGH GILL
Keyword(s):  
Water Absorption ◽  
Dosage Form ◽  
Stability Study ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Wetting Time

Objective: The present study aims to formulate and evaluate Fast dissolving tablet of Buspirone, the drug that is used for management of anxiety, by direct compression method using various Super disintegrants. Methods: Ten formulations (F1-F10) of fast dissolving tablets of Buspirone were prepared by using various Superdisintegrants. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption, wetting time, and disintegration time and in vitro dissolution study. Results: Among all the formulations, F10 (containing 5 mg of Coprocessed (CS: SSG 1:2) Superdisintegrants) was considered to be the best formulation, which released up to 98% drug in 20 min as compared to a marketed conventional dosage form which dissolves in approx 60 min. The results of stability study of formulation F10 after a period of two months indicated that the formulation was stable. Conclusion: It was concluded that a fast-dissolving tablet of Buspirone containing various Superdisintegrants is better and effective to meet patient compliance.

Development and Evaluation of Hydrodynamically Balanced System of Tramadol Hydrochloride by Using Chitosan and Locust Bean Gum

2020 ◽  
Author(s):  
Surabhi Ghildiyal
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Zero Order ◽  
Locust Bean Gum ◽  
Tramadol Hydrochloride ◽  
Gastric Residence Time ◽  
Release Pattern ◽  
Release Studies ◽  
Locust Bean

The main purpose of the study was the development and evaluation of a hydrodynamically balanced capsule of Tramadol HCl by using chitosan and locust bean gum as a natural polymer that prolongs the gastric residence time. Chitosan with different grades (low molecular weight, medium and high molecular weight) and locust bean gum were used as drug release retarding agents. The hydrodynamically balanced capsule of tramadol HCl was prepared by ordered mixing technique. The concentration of both the polymers was optimized to achieve the sustained release of the drug (TH) for 10 hours. Then the prepared capsules were evaluated for buoyancy test and in vitro drug release was performed and another characterization analysis was also considered like FTIR study, DSC/DTG/TGA study and interaction study were also performed based on characterization analysis. From these studies, it was confirmed that there is no interaction observed between drug and excipient. The drug release studies show that the retarding drug release pattern is dependent on the concentration and molecular weight of the polymer as the concentration /molecular weight increases the retarding drug release pattern was also improved. And the synergistic action of retarding drug release was observed by the addition of another polymer i.e locust bean gum. Release pattern was fitted with the different kinetic models like Zero order, First order, Higuchi model and KorsmeyerPeppas and it was concluded from the models that the drug release pattern obeys zero-order model which signifies high therapeutic efficacy and minimum side effects.

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