scholarly journals HISTOLOGICAL EFFECTS OF AQUEOUS EXTRACT OF BOSWELLIA DALZIELII STEM BARK ON THE TESTES OF ADULT WISTAR RATS

2015 ◽  
Vol 4 (5) ◽  
pp. 280-283
Author(s):  
Emmanuel A O ◽  
Adediji J A ◽  
Ehimigbai A R O
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Stem Bark

scholarly journals Possible Antioxidant and Haematinic Properties of the Stem Bark of Theobroma cacao L. in Wistar Rats

2021 ◽  
pp. 18-26
Author(s):  
B. O. Oluwatayo ◽  
T. A. Kolawole ◽  
C. C. Wali ◽  
O. A. Olayanju ◽  
A. E. J. Okwori
Keyword(s):  
Aqueous Extract ◽  
Theobroma Cacao ◽  
Wistar Rats ◽  
Antioxidant Activities ◽  
Research Work ◽  
Stem Bark ◽  
Dependent Manner ◽  
Group 2 ◽  
Dose Dependent ◽  
Theobroma Cacao L

Background: This study investigated the potential antioxidant effects of aqueous extract of the stem bark of Theobroma cacao L. in Wistar rats. Methods: Twenty Wistar rats weighing between 126 g – 224 g were grouped randomly into 4groups of 5 rats each. Group 1 served as control and received water while groups 2, 3 and 4 rats were given 1000mg/kg, 3000mg/kg and 5000mg/kg b.wt of the extract respectively for 28days. On the 29th day, the rats were anaesthetized and blood samples were collected for analysis of some haematological parameters, enzymatic and non- enzymatic antioxidant activities. Results: The results obtained showed that there was significant increase (p<0.001) in SOD, Catalase activities and MDA levels in a dose dependent manner. The results also showed significant increase (p<0.001) in RBC Group 2, 3 and 4 rats when compared to the Group1. Significant increase was also observed in Hemoglobin (Hb) and Hematocrit (Hct) level in group 2 and 3 rats (p<0.001). Mean corpuscular volume was significantly increased in group 2 rats (p<0.001). Conclusion: The findings from this study showed the antioxidant and hematinic potentials of the stem bark of Theobroma cacao L.The aqueous extract of the stem bark of Theobroma cacao L. has a potential antioxidative and hematinic effects in Wistar rats. This is largely due to its rich phytochemical and nutritive contents. Further research work will be needed to see the possible application of these properties in humans.

scholarly journals Effect of Allanblackia floribunda stem bark aqueous extract in male albino wistar rats: androgenic activities and penile nitric oxide (NO) production

2021 ◽  
Vol 7 (2) ◽  
pp. 63-73
Author(s):  
Antoine Kada Sanda ◽  
David Fotsing ◽  
Oumar Mahamat ◽  
Vijayakumar Natesan ◽  
Jayaprakash Rajendran ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Stem Bark ◽  
No Production

scholarly journals Endothelium/Nitric Oxide Mediates the Vasorelaxant and Antihypertensive Effects of the Aqueous Extract from the Stem Bark ofMammea africanaSabine (Guttiferae)

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Elvine Pami Nguelefack-Mbuyo ◽  
Alain Bertrand Dongmo ◽  
Télesphore Benoît Nguelefack ◽  
Albert Kamanyi ◽  
Pierre Kamtchouing ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Response Curve ◽  
Wistar Rats ◽  
Antihypertensive Effect ◽  
Stem Bark ◽  
Male Wistar Rats ◽  
Vasorelaxant Activity ◽  
Concentration Response Curve

This study evaluates the vasorelaxant and antihypertensive effects of the aqueous extract from the stem bark ofM. africana(AEMA). AEMA was testedin vitroon intact or endothelium-denuded rats’ aorta rings precontracted with KCl or norepinephrine in absence or in presence of L-NAME or glibenclamide. The effect of a single concentration (300 μg/mL) of AEMA was also examined on the concentration-response curve of KCl.In vivo, the antihypertensive effects of AEMA (200 mg/kg/day) were evaluated in male Wistar rats treated with L-NAME (40 mg/kg/day) for 4 weeks. AEMA relaxed aorta rings precontracted with NE or KCl with respective EC50 values of 0.36 μg/mL and 197.60 μg/mL. The destruction of endothelium or pretreatment of aorta rings with L-NAME shifted the EC50 of AEMA from 0.36 μg/mL to 40.65 μg/mL and 20.20 μg/mL, respectively. The vasorelaxant activity ofM. africanawas significantly inhibited in presence of glibenclamide. AEMA also significantly inhibited the concentration-response curve of KCl. Administered orally, AEMA induced acute and chronic antihypertensive effects and normalized renal NO level. These results show that the vasorelaxant activity of AEMA might be mediated by the activation of the NO-cGMP-ATP-dependent potassium channels pathway and might predominantly account for its antihypertensive effect.

scholarly journals Acute and Subacute Oral Toxicity Studies of the Aqueous Extract from the Stem Bark of Ricinodendron Rautanenii Schinz (Euphorbiaceae) in Wistar Rats

2020 ◽  
Vol 5 (08) ◽  
pp. 301-308
Author(s):  
Jacquy Joyce Wanche Kojom ◽  
Edwige Laure Nguemfo ◽  
Marie-Claire Tchamadeu ◽  
Calvin Bogning Zangueu ◽  
Edwige Laure Lappa ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Hematological Parameters ◽  
Stem Bark ◽  
Female Rats ◽  
Histopathological Analysis ◽  
Toxicity Assay ◽  
Subacute Toxicity ◽  
Male And Female Rats ◽  
Liver And Kidney

Ricinodendron rautanenii is a plant, used in traditional medecine to treat fever, eczema, back pain, cancer and stomacal disorders. This work was carried out to evaluate the safety of the aqueous extract from the stem bark of Ricinodendron rautanenii by determining its potential toxicity after acute and subacute administration in Wistar rats. In Acute toxicity assay, the animals received the extract at the single dose of 5000 mg/Kg and were observed during 48h for mortality and any toxicity manifestations. General behavior, adverse effects and mortality were determined for up to 14 days post treatment. In subacute toxicity assay, extract was given orally to rats at doses of 6, 20, 40 and 80 mg/kg/day for 28 days respectively. Animal body weight, water and food intake, biochemical and hematological parameters were determined. Liver and kidney were examined histologically for any signs of organ damage. No behavioral changes or mortality were recorded in the treated groups. No significant hematological changes were observed in the both sex. The biochemical analysis indicated a significant increase of high density lipoprotein levels in both male and female rats. Histopathological analysis of the liver and kidney did not show any observable cellular damages. The overall finding of this study suggest that, extract of Ricinodendron rautanenii did not cause any death up to a dose of 5000 mg/kg and can be considered non-toxic. Biochemical and histological studies of the extract did not revealed major signs in subacute toxicity.

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