Neurologic Outcome after Asphyxial Cardiac Arrest in a Juvenile Porcine Model: Comparison of Epinephrine and Vasopressin, Alone or Combined with Nitroglycerin

2016 ◽  
Vol 17 (9) ◽  
pp. 1-14
Author(s):  
Nektaria Lekka ◽  
Theofilos Kolettis ◽  
Giolanda Varvarousi ◽  
Theodoros Lappas ◽  
Sotirios Goulas ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Model Comparison ◽  
Porcine Model ◽  
Neurologic Outcome ◽  
Asphyxial Cardiac Arrest

Comparison of epinephrine and vasopressin in a pediatric porcine model of asphyxial cardiac arrest

2000 ◽  
Vol 28 (12) ◽  
pp. 3777-3783 ◽  
Author(s):  
Wolfgang G. Voelckel ◽  
Keith G. Lurie ◽  
Scott McKnite ◽  
Todd Zielinski ◽  
Paul Lindstrom ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Porcine Model ◽  
Asphyxial Cardiac Arrest

scholarly journals Hypothermia during Reperfusion after Asphyxial Cardiac Arrest Improves Functional Recovery and Selectively Alters Stress-Induced Protein Expression

2000 ◽  
Vol 20 (3) ◽  
pp. 520-530 ◽  
Author(s):  
Shawn D. Hicks ◽  
Donald B. DeFranco ◽  
Clifton W. Callaway
Keyword(s):  
Cardiac Arrest ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Expression ◽  
Brain Temperature ◽  
Neurologic Outcome ◽  
Ca1 Region ◽  
Neurobehavioral Deficits ◽  
Related Proteins ◽  
Asphyxial Cardiac Arrest

This study examined whether prolonged hypothermia induced 1 hour after resuscitation from asphyxial cardiac arrest would improve neurologic outcome and alter levels of stress-related proteins in rats. Rats were resuscitated from 8 minutes of asphyxia resulting in cardiac arrest. Brain temperature was regulated after resuscitation in three groups: normothermia (36.8°C × 24 hours), immediate hypothermia (33°C × 24 hours, beginning immediately after resuscitation), and delayed hypothermia (33°C × 24 hours, beginning 60 minutes after resuscitation). Mortality and neurobehavioral deficits were improved in immediate and delayed hypothermia rats relative to normothermia rats. Furthermore, both immediate and delayed hypothermia improved neuronal survival in the CA1 region of the hippocampus assessed at 14 days. In normothermia rats, the 70-kDa heat shock protein (Hsp70) and 40-kDa heat shock protein (Hsp40) were increased within 12 hours after resuscitation in the hippocampus. Delayed hypothermia attenuated the increase in Hsp70 levels in the hippocampus but did not affect Hsp70 induction in the cerebellum. Hippocampal expression of Hsp40 was not affected by hypothermia. These data indicate that prolonged hypothermia during later reperfusion improves neurologic outcome after experimental global ischemia and is associated with selective changes in the pattern of stress-induced protein expression.

Epinephrine, vasopressin, and nitroglycerin improve neurologic outcome in porcine asphyxial cardiac arrest

2012 ◽  
Vol 30 (8) ◽  
pp. 1549-1554 ◽  
Author(s):  
Giolanda Varvarousi ◽  
Sotirios Goulas ◽  
Georgios Agrogiannis ◽  
Nikolaos Valsamakis ◽  
Dimitrios Iliopoulos ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Neurologic Outcome ◽  
Asphyxial Cardiac Arrest

A Comparison of the Combination of Epinephrine and Vasopressin with Lipid Emulsion in a Porcine Model of Asphyxial Cardiac Arrest After Intravenous Injection of Bupivacaine

2008 ◽  
Vol 106 (5) ◽  
pp. 1566-1571 ◽  
Author(s):  
Viktoria D. Mayr ◽  
Lukas Mitterschiffthaler ◽  
Andreas Neurauter ◽  
Christian Gritsch ◽  
Volker Wenzel ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Intravenous Injection ◽  
Lipid Emulsion ◽  
Porcine Model ◽  
Asphyxial Cardiac Arrest

Effect of valproic acid combined with therapeutic hypothermia on neurologic outcome in asphyxial cardiac arrest model of rats

2015 ◽  
Vol 33 (12) ◽  
pp. 1773-1779 ◽  
Author(s):  
Jae Hyuk Lee ◽  
Kyuseok Kim ◽  
You Hwan Jo ◽  
Min Ji Lee ◽  
Ji Eun Hwang ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Neurologic Outcome ◽  
Asphyxial Cardiac Arrest

Neuroprotective effects of dexmedetomidine-hypothermia after asphyxial cardiac arrest in rats

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S27-S27
Author(s):  
Tetsu Kimura ◽  
Toru Goyagi ◽  
Makoto Tanaka ◽  
Yoshitsugu Tobe ◽  
Yoko Masaki ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Neuroprotective Effects ◽  
Asphyxial Cardiac Arrest
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