scholarly journals Plasma Levels of Connective Tissue Growth Factor in Children with Congestive Heart Failure

2020 ◽  
pp. 110-116
Author(s):  
Riham Mahmoud Wagieh ◽  
Ahmed Hamdy Shabana ◽  
Hesham Mohammed Elserogy ◽  
Amr Mohamed Zoair
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Growth Factor ◽  
Plasma Level ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Prognostic Value ◽  
Tissue Growth ◽  
Factor Level ◽  
Diagnostic And Prognostic Value

Objectives: Assessment of plasma level of connective tissue growth factor in congestive heart failure children, assessment of its diagnostic and prognostic role and correlate its level with clinical and echocardiographic assessment of congestive heart failure. Methods: Connective tissue growth factor level in the plasma was measured in 40 children; 20 of them have congestive heart failure, and 20 are healthy then, correlated with clinical parameters. Results: The diagnostic and prognostic value of it was evaluated. We compared its levels in both patients and healthy children. We found that connective tissue growth factor level was significantly increased in diseased children. Fractional shortening and ejection fraction correlated negatively with the plasma level of connective tissue growth factor. Heart rate, respiratory rate and calibrated integrated backscatter correlated positively with connective tissue growth factor. Connective tissue growth factor was significantly correlated with the class of heart failure according to Ross classification. Conclusions: Plasma connective tissue growth factor has a promising diagnostic and prognostic value as a biomarker for congestive heart failure in children with high sensitivity and specificity.

Connective tissue growth factor (CTGF/CCN2): diagnostic and prognostic value in acute heart failure

2013 ◽  
Vol 103 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Michael Behnes ◽  
Martina Brueckmann ◽  
Siegfried Lang ◽  
Christel Weiß ◽  
Parviz Ahmad-Nejad ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Factor ◽  
Connective Tissue ◽  
Acute Heart Failure ◽  
Connective Tissue Growth Factor ◽  
Prognostic Value ◽  
Tissue Growth ◽  
Diagnostic And Prognostic Value

The diagnostic value of plasma N-terminal connective tissue growth factor levels in children with heart failure

2016 ◽  
Vol 27 (1) ◽  
pp. 101-108
Author(s):  
Gang Li ◽  
Xueqing Song ◽  
Jiyi Xia ◽  
Jing Li ◽  
Peng Jia ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Factor ◽  
Connective Tissue ◽  
Brain Natriuretic Peptide ◽  
Healthy Volunteers ◽  
Connective Tissue Growth Factor ◽  
Area Under Curve ◽  
Diagnostic Value ◽  
Left Ventricular ◽  
Tissue Growth

AbstractObjectiveThe aim of this study was to assess the diagnostic value of plasma N-terminal connective tissue growth factor in children with heart failure.Methods and resultsPlasma N-terminal connective tissue growth factor was determined in 61 children, including 41 children with heart failure, 20 children without heart failure, and 30 healthy volunteers. The correlations between plasma N-terminal connective tissue growth factor levels and clinical parameters were investigated. Moreover, the diagnostic value of N-terminal connective tissue growth factor levels was evaluated. Compared with healthy volunteers and children without heart failure, plasma N-terminal connective tissue growth factor levels were significantly elevated in those with heart failure (p<0.01). N-terminal pro-brain natriuretic peptide and left ventricular end-diastolic dimension were positively correlated with plasma N-terminal connective tissue growth factor levels (r=0.364, p=0.006; r=0.308, p=0.016), whereas there was a negative correlation between left ventricular ejection fraction and plasma N-terminal connective tissue growth factor (r=−0.353, p=0.005). Connective tissue growth factor was significantly correlated with the severity of heart failure (p<0.001). Moreover, addition of connective tissue growth factor to N-terminal pro-brain natriuretic peptide did not significantly increase area under curve for diagnosing heart failure (area under curve difference 0.031, p>0.05), but it obviously improved the ability of diagnosing heart failure in children, as demonstrated by the integrated discrimination improvement (6.2%, p=0.013) and net re-classification improvement (13.2%, p=0.017) indices.ConclusionsPlasma N-terminal connective tissue growth factor is a promising diagnostic biomarker for heart failure in children.

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