scholarly journals Lewis Blood Group Percentage Distribution among Indigenes of Ogoni Ethnicity in Rivers State, Nigeria

2020 ◽  
pp. 108-113
Author(s):  
Serekara Gideon Christian ◽  
Evelyn Mgbeoma Eze ◽  
Beatrice Wobiarueri Moore-Igwe
Keyword(s):  
Blood Group ◽  
Blood Group Antigens ◽  
Serological Screening ◽  
Percentage Distribution ◽  
Lewis Blood Group ◽  
North East ◽  
The North ◽  
Lewis Antigen ◽  
Port Harcourt ◽  
Rivers State

Aim: We attempted to determine the frequency and percentage distribution of Lewis blood group antigens among indigenes of Ogoni ethnicity in Rivers State, Nigeria. Study Design: The study consisted of 101 Ogoni people, who were apparently healthy and free from transfusion transmissible infections confirmed by serological screening. Ogoniland is located along the Niger Delta Eastern edge, and to the north-east of the Imo River and Port Harcourt city. All subjects were recruited and their blood samples were collected. The presence of Lewis-a and -b (Lea/Leb) blood group was examined using Anti-Lea and Leb monoclonal antibody, respectively (Lorne Laboratories). Results: Lea and Leb blood group was observed in 17.8% and 11.9%, respectively. Conclusion: Lea and Leb in this population was observed less frequently than those in other population previously reported. The Lewis antigen was reported to be associated with thrombotic disorders and Helicobacter pylori infection. Further studies may be directed to examine the association between Lewis blood group antigens and the risk of these conditions in Ogoni subjects.

scholarly journals Kell Blood Group Antigens Not Found in Indigenes of Ogoni Ethnic Group of Rivers State, Nigeria

2020 ◽  
pp. 1-5
Author(s):  
Serekara Gideon Christian ◽  
Evelyn Mgbeoma Eze ◽  
Anthony Chijioke Uzoanya Ezimah ◽  
Fiekumo Igbida Buseri
Keyword(s):  
Ethnic Group ◽  
Blood Group ◽  
Niger Delta ◽  
Parental Origin ◽  
Blood Group Antigens ◽  
Frequency Of Occurrence ◽  
Expiry Date ◽  
Percentage Distribution ◽  
Port Harcourt ◽  
Rivers State

Aim: The aim of the study was to determine the frequency of occurrence and percentage distribution of Kell blood group antigens in indigenes of Ogoni ethnic group of Rivers State, Nigeria. Study Design:  This was a cross-sectional study carried out among indigenes of Ogoni whose first generational parental origin is Ogoni. A total of 101 subjects (49 females and 52 males), within the age of 30–60 years were recruited for the study and they were apparently healthy and free from transfusion transmissible infections upon serological screening. Place and Duration of Study: Ogoniland is located in an area along the Niger Delta Eastern edge, and to the north-east of the Imo River and Port Harcourt city. Ogoniland covers about 1036 Sq Km and borders the Bay of Guinea. All participants were recruited in Bori. Bori is the traditional headquarter of Ogoni. Bori is located on latitude: 4040ʹ34.64ʺ N and longitude: 7021ʹ54.68ʺ E. The analysis was carried out at the Post Graduate Laboratory of Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria. Port Harcourt, the capital of Rivers State, is located on latitude 4.750N and longitude 7.000E and lies along Bonny River in the Niger Delta. All subjects were recruited the same day and their blood samples collected on 2nd October, 2019, and analysis conducted on 3rd October, 2019. Methodology: Identification of Kell blood group antigens was done using Anti-Kell monoclonal reagent, prepared by Lorne Laboratories Ltd, UK. Lot No: 76090-A5; Expiry Date: 2021/02/21. Phenotyping of red cells was done using tube method as described by Lorne Laboratory Ltd. Results: The result showed zero frequency of occurrence and percentage distribution of Kell blood group antigen in the studied population (49 males and 52 females). Conclusion: The presence of Kell blood group antigens in indigenes of Ogoni recruited for the study which serve as representative of the Ogonis was rare. It is therefore necessary to take into cognizance that haemolytic transfusion reactions due to Kell antigens and antibodies will rarely occur, and as such Kell blood group is not significant in blood transfusion and in antenatal and blood group serology amongst the Ogonis.

Lewis Blood Group Antigens in Salivary Glands and Stratified Epithelium: Lack of Regulation of Lewis Antigen Expression in Ductal and Buccal Mucosal Lining Epithelia

Vox Sanguinis ◽  
1991 ◽  
Vol 61 (3) ◽  
pp. 205-214
Author(s):  
Ulla Mandel ◽  
Torben F. Ørntoft ◽  
Eric H. Holmes ◽  
Henning Sørensen ◽  
Henrik Clausen ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Blood Group ◽  
Antigen Expression ◽  
Blood Group Antigens ◽  
Stratified Epithelium ◽  
Lewis Blood Group ◽  
Lewis Antigen ◽  
Mucosal Lining

Association of Recurrent Candidal Vaginitis with Inheritance of Lewis Blood Group Antigens

1995 ◽  
Vol 172 (6) ◽  
pp. 1616-1619 ◽  
Author(s):  
E. Hilton ◽  
V. Chandrasekaran ◽  
P. Rindos ◽  
H. D. Isenberg
Keyword(s):  
Blood Group ◽  
Blood Group Antigens ◽  
Lewis Blood Group

scholarly journals Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity.

1996 ◽  
Vol 64 (6) ◽  
pp. 2031-2040 ◽  
Author(s):  
B J Appelmelk ◽  
I Simoons-Smit ◽  
R Negrini ◽  
A P Moran ◽  
G O Aspinall ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Potential Role ◽  
Molecular Mimicry ◽  
Blood Group Antigens ◽  
Lewis Blood Group

scholarly journals Association between secretor status and Lewis phenotype with seronegative spondyloarthritis as indicator of autoimmunity

Genetika ◽  
2020 ◽  
Vol 52 (1) ◽  
pp. 127-136
Author(s):  
Ivan Busarcevic ◽  
Svetlana Vojvodic ◽  
Una Vojvodic
Keyword(s):  
Blood Group ◽  
Haemagglutination Inhibition ◽  
Gastrointestinal Symptoms ◽  
Blood Group Antigens ◽  
Control Subjects ◽  
Secretor Status ◽  
Lewis Blood Group ◽  
Increased Risk ◽  
Significant Difference ◽  
Seronegative Spondyloarthropathies

The classical paradigm of autoimmune pathogenesis involving specific genetic makeup and exposure to environmental triggers has been challenged recently by the addition of a third element, the loss of intestinal barrier function. Regardless of HLA B27 phenotype or gastrointestinal symptoms, evidence of ileitis, ileocolitis or colitis exists in patients with spondyloarthropathy. The FUT2 secretory gene is a strong candidate for Crohn's susceptibility by shaping the functional states of mucosal microbiota and may thus have influence on the release of zonulin, the main regulator of gut permeability. Gram negative bacteria precipitate and may be involved in the pathogenesis of spondyloarthropathies. Susceptibility to many infectious agents is associated with ABO blood group or secretor state. Patients who cannot secrete ABO and Lewis blood group antigens into body fluids, an ability controlled by a single gene on chromosome 19, are known to be at increased risk of certain autoimmune diseases associated with human leukocyte antigen (HLA) markers. Lewis (Le) blood group phenotype can be used to infer secretor status. The objective of this study was to determine the distribution of secretor state and Lewis blood group phenotype in patients with seronegative spondyloarthropathies and healthy control subjects. Hundred and ten (110) patients with seronegative spondyloarthropathies (58 females and 52 males) and 103 control (74 males and 29 females) subjects participated in this study. Samples of saliva and blood were subjected to haemagglutination inhibition tests for determination of secretor status and Lewis phenotype. A total of 92(84%) patients and 92 (89%) control subjects were secretors while 18 (16%) patients and 11 (11%) control subjects were non-secretors. There was no statistically significant difference (?2 1,461 p<0,05 and degrees of freedom 1) in distribution of secretor status in comparison to seronegative spondyloarthropathies by comparing two observed populations. Seven patients had modified (reduced) expression of Lewis b antigen on their erythrocytes. Reduction of Lewis b antigen expression was not observed on erythrocytes of healthy subjects. Reduced expression of Lewis b antigen could be a consequence of the inflammatory process within the gut and it also suggests several pathogenic mechanisms which may be relevant to the synthesis of Lewis antigens inside the gut or its absorption on erythrocytes in patients with spondyloarthropathy.

scholarly journals Changes of the expression of Lewis blood group antigens in glycoproteins of renal cancer tissues.

2013 ◽  
Vol 60 (2) ◽  
Author(s):  
Małgorzata Borzym-Kluczyk ◽  
Iwona Radziejewska
Keyword(s):  
Sialic Acid ◽  
Blood Group ◽  
Tumor Development ◽  
Renal Tissue ◽  
Cancer Tissue ◽  
Blood Group Antigens ◽  
Lewis Blood Group ◽  
Significant Difference ◽  
Cancer Tissues ◽  
Sialyl Lewisa

Sialic acid and sialyl Lewisa/x are found on N- and O-glycans of many human malignant cells. Carbohydrate antigens can be used as tumor markers, and an increase of their levels in cancer cells is associated with tumor progression. The aim of this study was to assess the level of some Lewis blood group antigens on glycoproteins in tumor (cancer tissue), intermediate zone (adjacent to tumor tissue), and normal renal cortex/medulla (uninvolved by tumor). The study was performed on tissues taken from 30 patients. Relative amounts of sugar structures of proteins with molecular masses above 30 kDa were determined by ELISA-like test with biotinylated lectins: MAA (Maackia amurensis), SNA (Sambucus nigra), and monoclonal antibodies anti-sialyl Lewisa/x.∙ Higher expression of all examined structures was revealed in cancer tissues. Significant increases were observed for sialic acid linked α 2-3 in cancer tissues when compared to healthy ones and also among intermediate and healthy tissues. The sialic acid linked α 2-6 and sialyl Lewisx structures were significantly increased in cancerous cells when compared to normal and intermediate renal tissue. In case of sialyl Lewisa antigen, a significant difference was discovered between normal and intermediate tissue. Our results confirm that the examined Lewis antigens can be involved in tumor development. Their increase in cancer tissues can suggest their specific role in the process.

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