scholarly journals Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Chengguo Zuo ◽  
Dingqiao Wang ◽  
Xinxing Guo ◽  
Hui Xiao ◽  
Shaoyang Zheng ◽  
...  
Keyword(s):  
Characteristic Curve ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Malignant Glaucoma ◽  
Choroidal Vasculature ◽  
Control Study ◽  
Fellow Eyes ◽  
Sd Oct

Purpose: To compare the choroidal vasculature characteristics by using the choroidal vascularity index (CVI) in eyes with malignant glaucoma (MG), fellow eyes with non-MG, and eyes with uncomplicated primary angle-closure glaucoma (PACG) after trabeculectomy by spectral-domain optical coherence tomography (SD-OCT).Methods: This case–control study included 53 patients diagnosed with MG after trabeculectomy. Eyes with MG (n = 53) and the fellow eyes with non-MG (n = 50) were included. Eyes with PACG without MG after trabeculectomy (n = 60) were also enrolled as controls. The choroidal parameters, including CVI and the subfoveal choroidal thickness (SFCT), were measured by using SD-OCT images.Results: Eyes with MG and the fellow eyes showed a significantly lower CVI than eyes with PACG controls (p < 0.001). After adjusting for age, sex, axial length (AL), and intraocular pressure (IOP), eyes with the greater CVI [odds ratio (OR), 0.44] were significantly related to MG. The area under the receiver operating characteristic curve of the CVI was greater than that of the SFCT in the diagnosis of MG (0.911 vs. 0.840, p = 0.034).Conclusion: Eyes with MG showed a significantly lower macular CVI than eyes with PACG controls. A higher macular CVI was an associated factor of eyes with MG. The CVI serves as a more stable and sensitive indicator for MG than the SFCT in this group of patients with PACG.

scholarly journals Levels of Plasma 8-Hydroxy-2'-Deoxyguanosine—A Marker of Oxidative DNA Damage—Are Not Associated with Primary Angle-closure Glaucoma

2021 ◽  
pp. 132-138
Author(s):  
Altaf A. Kondkar
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Statistical Significance ◽  
Characteristic Curve ◽  
Angle Closure Glaucoma ◽  
University Hospital ◽  
Angle Closure ◽  
Clinical Markers ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Aim: The study aimed to estimate plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, a marker of oxidative deoxyribonucleic acid (DNA) damage, and evaluate their potential association with primary angle-closure glaucoma (PACG) and related clinical markers. Study Design: This is retrospective case-control study. Place and Duration: The study was performed on samples recruited from King Abdulaziz University Hospital, Riyadh, Saudi Arabia between August 2018 through September 2019 in the participants of Saudi origin. Methodology: Plasma 8-OHdG levels were measured in duplicates using automated ELISA analyzer in 43 PACG patients and 45 non-glaucomatous controls. Results: The mean levels of 8-OHdG were 13.59 ng/mL [±4.50] in PACG patients compared to 16.95 ng/mL [±10.66] in controls. The differences did not achieve statistical significance (P = 0.06). Similarly, no significant differences (P = 0.42) were observed in the median levels of 8-OHdG between PACG and controls. Furthermore, except for sex, where males exhibited a significant negative correlation (R = -0.35, P = 0.02), there was no significant correlation between 8-OHdG levels and age (P = 0.85), intraocular pressure (P = 0.58), cup/disc ratio (P = 0.39) and number of antiglaucoma medications (P = 0.41) in the PACG group. Regression analysis showed no significant influence of age, sex, and 8-OHdG levels on PACG outcome. Besides, the area under the receiver operating characteristic curve was 0.55 and non-significant (P = 0.42). Conclusion: There is no association between plasma levels of 8-OHdG and PACG or its specific clinical markers. Further studies in a much larger cohort are needed to validate these findings.

scholarly journals Malignant Glaucoma: A Review of the Modern Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
H. Shahid ◽  
J. F. Salmon
Keyword(s):  
Angle Closure Glaucoma ◽  
Treatment Modalities ◽  
Angle Closure ◽  
Medical Laser ◽  
Rare Form ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Asian Patients ◽  
Malignant Glaucoma ◽  
High Prevalence

Malignant glaucoma is a rare form of glaucoma that typically follows surgery in patients with primary angle closure and primary angle-closure glaucoma. In this paper, the clinical features, classification, pathogenesis, and principles of management are discussed. Despite a high prevalence of primary angle closure glaucoma in South-East Asia, the vast majority of cases of malignant glaucoma are reported in White populations. This may reflect differing mechanisms of angle closure in White and Asian patients, which somehow reduces the likelihood of an aberrant relationship developing between the lens, ciliary body, anterior hyaloid, and vitreous structures within the eye. Although the exact underlying pathogenic mechanism remains unclear, the prognosis is good with modern medical, laser, and surgical treatment modalities.

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