Background :
At present, 63 percent of women and 72 percent of men are obese. Obesity is a condition that causes increased rates of type 2 diabetes mellitus, heart disease, and arthritis, amongst other conditions. It was found that Neeri can control cholesterol and triglycerides levels which are associated with obesity. Therefore, Neeri has been assumed to treat obesity. Based on its efficacy to reduce cholesterol and triglycerides levels, it was assumed that it can be active against obese in-vivo.
Methods :
In-vivo studies were performed by utilizing albino Wistar rats (100–250g) approved and procured by IAEC resolution no. 2017/837/ac/MPH/12 from the animal house of the Institute of Foreign Trade and Management [IFTM] University, Moradabad, India. The Neeri was administered at different concentrations into five groups of obesity-induced albino Wistar rats, all the groups were treated for 42nd successive days accordingly and the in-vivo tests were performed on the 43rd day. Biochemical serum analysis was measured by ELISA assay.
Results :
Outcomes were expressed as Mean±SEM. The difference between experimental groups was compared by one-way analysis of variance (ANOVA) followed by Dennett’s test and was considered statistically significant when p<0.05. It was found a significant (p<0.05) decrease in total cholesterol triglycerides, low-density lipoprotein, and very high-density lipoprotein and along with increased high-density lipoprotein.
Conclusion :
Neeri can reduce body weight, cholesterol, triglycerides, low-density lipoprotein and very-low-density lipoprotein level, liver weight, heart weight, uterine fat, mesenteric fat, and kidneys weight level similar to the standard drug. It was concluded that Neeri Ayurvedic formulation can produce pharmacological action similar to the standard drug, Orlistat. In the future, further studies may proceed and Neeri tablets can be repurposed against obesity.
Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo.
