scholarly journals Evaluation of Antacid Potential of Ayurvedic Poly-Herbal Formulation for Functional Dyspepsia

2021 ◽  
pp. 12-21
Author(s):  
Alpana Kulkarni ◽  
Dinesh Pandit ◽  
Sanket Walke ◽  
Ajit Kolatkar
Keyword(s):  
Functional Dyspepsia ◽  
Sodium Citrate ◽  
Analytical Techniques ◽  
Tween 80 ◽  
Acid Neutralizing Capacity ◽  
Taste Masking ◽  
Sodium Carboxymethylcellulose ◽  
Neutralization Capacity ◽  
Neutralizing Capacity ◽  
Stability And Accuracy

Aim: Ayurveda describes herbal or polyherbal or herbo-mineral medicines such as Avipattikar churna for treatment of Amlapitta, ajirna for centuries. Ayurvedic medicines are associated with limitations namely, palatability, stability and accuracy of dose. Ayurvedic medicines lack in adequate safety and efficacy evidence data. The aim of the study was to develop a stable and palatable Avipattikar suspension using recent formulation and analytical techniques. The study was also aimed at determination of acid neutralizing capacity of Avipattikar suspension and predicting its efficacy for treatment of Functional Dyspepsia and Gastroesophageal Reflux Disorder. Methods: Flocculated Avipattikar suspension was prepared using sodium carboxymethylcellulose (CMC) as the suspending agent, sodium citrate as the flocculating agent, mannitol as a taste masking agent. Sodium carboxymethylcellulose, sodium citrate, Tween 80®, glycerin and mannitol were not used in Deflocculated Avipattikar suspension. The sedimentation volume, degree of flocculation, redispersibility and pH of the suspension was evaluated. The acid neutralization capacity of Avipattikar suspension was determined by Unite States Pharmacopoeia method. Results: The present study successfully demonstrated formulation of stable Avipattikar suspension from Avipattikar churna.  The suspendability of sediment was retained for 15 days in presence of CMC. The results indicated that the acid neutralizing capacity of Avipattikar suspension (2.80 mMol of H+/ gm) was similar to that of the marketed antacid suspension (2.756 mMol of H+/ gm). The unpleasant taste of herbal drugs was masked satisfactorily. Conclusion: Avipattikar suspension may be a cheaper, safer and effective alternative for current antacids for the treatment of functional dyspepsia.

scholarly journals Acid neutralizing capacity, an important waste management parameter

2020 ◽  
Vol 2 (2) ◽  
pp. 166-169
Author(s):  
Georgiana Cernica ◽  
◽  
Gina Alina Catrina ◽  
Georgeta Madalina Arama ◽  
Agnes Serbanescu ◽  
...  
Keyword(s):  
Waste Management ◽  
Industrial Waste ◽  
Acid Neutralizing Capacity ◽  
Acid Neutralization ◽  
Essential Information ◽  
Neutralization Capacity ◽  
Acid Neutralization Capacity ◽  
Successful Method ◽  
Neutralizing Capacity

The paper presents the influence of acid neutralization capacity in industrial waste samples as a decision indicator. For the analysis of the acid neutralization capacity, six samples of wastes from different sectors of activity were subjected. A successful method that can be applied to determine the properties of waste is acidneutralizing capacity. The acid-neutralizing capacity was evaluated with HCl 1 N by neutralizing the excess with NaOH 0.5 N after 15 min stirring. From the results obtained it is found that the acid neutralization capacity can provide essential information for the subsequent management of the waste.

scholarly journals Acid Neutralizing Capacity of Selected Antacid Suspensions Available in the Ghanaian Market

2020 ◽  
pp. 10-15
Author(s):  
Cedric Dzidzor Kodjo Amengor ◽  
Owusu Frederick William Akuffo ◽  
James Kwaning ◽  
Albara Halidu Iddrisu ◽  
Alexander Ohemeng ◽  
...  
Keyword(s):  
Magnesium Hydroxide ◽  
Aluminium Hydroxide ◽  
Symptomatic Relief ◽  
Acid Neutralizing Capacity ◽  
Acid Neutralization ◽  
Neutralization Capacity ◽  
Acid Neutralization Capacity ◽  
Weak Bases ◽  
Neutralizing Capacity ◽  
One Year

Antacids are substances commonly used by patients to obtain fast symptomatic relief from dyspepsia. They are weak bases which neutralize excess gastric acid and subsequently raise the pH of the gastric contents. The potency of the antacids depends mainly on their acid neutralization capacity (ANC) and this can vary from one brand to another. Several dosage forms of antacids are available for use by patients. However, In Ghana, suspensions are the commonest dosage form of antacids which is preferred by patients. The objective of this study was to determine the acid neutralizing capacity of six (6) randomly selected brands of antacid suspensions on the Ghanaian market using potentiometric acid-base titration. The samples were coded A-F to avoid any bias in the study. All the sampled brands had more than one year to expiry as indicated on their label. Brand D had the highest ANC of 29.70 mEq/dose whiles brand A had the lowest ANC of 11.25 mEq/dose. From the results obtained, it can be inferred that acid neutralization can be more effective and rapidly achieved with liquid antacids containing a high amount of magnesium hydroxide and aluminium Hydroxide. Hence, for acute symptomatic relief from dyspepsia, antacids containing a higher concentration of magnesium hydroxide and aluminium hydroxide would be most beneficial to patients.

Evaluation of Hemidesmus indicus root as an antacid by In vitro

2016 ◽  
Vol 5 (04) ◽  
pp. 4524
Author(s):  
Abdullah Shaikh Farooque ◽  
Md. Azharuddin Ismail Atar*
Keyword(s):  
Skin Diseases ◽  
Care Delivery ◽  
Health Care Delivery System ◽  
Acid Neutralizing Capacity ◽  
Standard Drug ◽  
Hemidesmus Indicus ◽  
Neutralizing Capacity ◽  
Loss Of Appetite ◽  
Powdered Drug

Medicinal plants are being widely used, either as single drug or in combination in health care delivery system. Indian Sarsaparilla, Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant, which is widely recognized in traditional systems of Medicine. It contains various phytoconstituents belonging to the category glycosides, flavonoids, tannins, sterols and volatile oils. It has been reported as useful in biliousness, blood diseases, dysentery, diarrhea, respiratory disorders, skin diseases, syphilis, fever, leprosy, leucoderma, leucorrhoea, itching, bronchitis, asthma, eye diseases, epileptic fits in children, kidney and urinary disorders, loss of appetite, burning sensation, dyspepsia, nutritional disorders, ulcer and rheumatism. Several studies are being carried towards its activities like analgesic, anti-inflammatory, antiulcer, hepatoprotective, antioxidant and helicobactericidal properties. In our study we have evaluated antacid activity of sariva (Anantmool) by using In-Vitro method, i.e. ANC (Acid Neutralizing Capacity). This evaluation was done by comparing the ANC of sariva macerated & powdered drug with water as blank & standard drug i.e. NaHCO3. Based on this In-Vitro experiment, we can conclude that, the macerated & powdered drug of sariva (Anantmool) evaluated in this study, varied in potency as measured in terms of their ANC. These results having ** i.e. P < 0.01 & Passed the normality test. However, the present study being in-vitro, the effects of antacid may vary In-Vitro; individual variations also contribute to the ultimate effectiveness of as antacid.        

scholarly journals In-vitro antiulcer activities of petal extract of Crocus sativus var. cashmerianus

2020 ◽  
pp. 6-8
Author(s):  
Vijender Kumar ◽  
Poonam Verma ◽  
Amarjit Kaur ◽  
Baljinder Singh
Keyword(s):  
Crocus Sativus ◽  
Acid Neutralizing Capacity ◽  
Inhibition Activity ◽  
Similar Dose ◽  
Neutralizing Capacity ◽  
Activity Method ◽  
Atpase Inhibition ◽  
Acid Neutralize ◽  
Capacity Method

Medicinal plants have been known for millennia as a rich source of traditional therapeutic agents for the prevention of diseases and ailments. The aim of the present study was performed to evaluate the antiulcer activities of hydro-alcoholic extracts of petals of Crocus sativus var. Cashmerianus by in-vitro methods viz. acid neutralizing capacity and H+/K+ - ATPase inhibition activity. In acid neutralizing capacity method, the petals extract significantly reduced acidity to 6.10 at a concentration of 1000 mg/ml as compared to 11.90 with standard 500 mg/ml of Aluminium hydroxide + Magnesium hydroxide combination. However, H+/K+ - ATPase inhibition activity method, petals extract showed maximum percentage inhibition of 70.31 % at the concentration 400µg/ml as compared to 73.82 % with a similar dose of standard Omeprazole. The IC 50 value of petals extract of C. sativus var. cashmerianus is shown 100 µg/ml in comparison with standard omeprazole of 82.5 µg/ml. The study reveals that the petals extract of C. sativus var. cashmerianus may contain compounds possessing acid neutralize and enzyme inhibition activities, thus it can be used as an alternative medicine for gastrointestinal disorders.

Vilazodone Hydrochloride Multi-Dose Nasal Spray Solution for the Treatment of Depression: Design, Optimization, and Evaluation

2021 ◽  
Vol 16 ◽  
Author(s):  
Praful Giradkar ◽  
Deepa H. Patel
Keyword(s):  
Nasal Spray ◽  
Benzalkonium Chloride ◽  
Research Work ◽  
Tween 80 ◽  
Oral Route ◽  
Sodium Carboxymethylcellulose ◽  
Intranasal Route ◽  
Spray Solution ◽  
Treatment Of Depression ◽  
The Brain

Introduction: The aim of present research work was to prepare, optimized, and evaluate the multi-dose nasal spray solution for delivery of vilazodone hydrochloride to the brain by the intranasal route in order to overcome the drawback associated with the oral route for the treatment of depression. Background: Depression is a mental disorder associated with abnormalities in neuronal transport in the brain primarily serotonin, norepinephrine, and dopamine that adversely affects a person's lifestyle, sleep pattern, work, eating habits, and general health. Vilazodone hydrochloride acts by enhancing the serotonergic activity in the brain by inhibiting serotonin (5-HT) reuptake. Materials/ Methods: The excipients used to formulate vilazodone hydrochloride multi-dose nasal spray solution were sulphobutylether-β-cyclodextrin sodium (solubilizer), sodium carboxymethylcellulose (viscosity builder), tween 80 (surface tension modifier), glycerol (humectant), benzalkonium chloride (preservative), and purified water (vehicle). The simple conventional mixing technique was used for the preparation of the multi-dose nasal spray solution. The solution was prepared in two parts, in the first part sulphobutylether-β-cyclodextrin sodium and drug substance dissolved in purified water under stirring followed by the addition of glycerol and benzalkonium chloride solution. In the second part, tween 80 dissolved in warm water followed by the addition of sodium carboxymethylcellulose under stirring, finally both parts mixed and the required volume was adjusted with purified water. The central composite design was used for the optimization of the formulation. The solution was evaluated for physicochemical properties, selective toxicity, and experimental kinetics. Results: The prepared vilazodone hydrochloride multi-dose nasal spray solution was shown viscosity (40.5 ± 1.65 mPa.s), droplet size distribution (span) (1.88 ± 0.55 µm), spray area (288 ± 1.25 mm2), ovality (1.10 ± 1.35), dripping speed (0.25 cm /30 sec), visual appearance (clear free from particulate matter), pH (6.35 ± 0.10), shot weight (100.6 ± 0.32 mg), density (1.03 ± 0.20 g/ml), % drug content (101.8 ± 0.15 %), displacement value for in-vitro mucoadhesion (3.47 ± 0.25 cm), average flux (Jss) for permeability (241.06 ± 1.45 μg/cm2/hrs), permeability coefficient (48.21 ±1.46 cm/hrs), enhancement ratio (1.73), local toxicity study shows no epithelium cell damage, isotonicity (386.58 mOsmol / kg). Plasma Cmax (24.56 ±3.98 ng/ml), Tmax (1.0 hrs), and AUC 0-12 (82.68 ±10.22 ng.h/ml). Brian tissue Cmax (22.95 ±4.22), Tmax (1.0 hrs) and AUC 0-12 (77.82 ±6.25 ng.h/ml). Nasal bioavailability (251.74 ±45.12% ) and, drug targeting index 1.54 Conclusion: The present research work results showed that the prepared multi-dose nasal spray solution of vilazodone hydrochloride was suitable for the delivery of the drug to the brain by the intranasal route and might be beneficial to overcome drawbacks associated with the oral route of administration for the treatment of depression.

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