scholarly journals Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia

2020 ◽  
pp. 114-117
Author(s):  
Debajani Tripathy ◽  
Chandana Adhikari ◽  
Mukundjee Pandey ◽  
Bhagyeswari Behera ◽  
Srimay Pradhan ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Drug Discovery ◽  
Aeromonas Hydrophila ◽  
Bioactive Compound ◽  
Clinical Test ◽  
Phytochemical Analysis ◽  
Acetaldehyde Dehydrogenase ◽  
Discovery Studio ◽  
Dehydrogenase Enzyme ◽  
Phytochemical Extraction

For drug discovery it takes approximately 6 years to expose in the market and for commercial uses. There are different procedure to get success in the drug discovery like preliminary phytochemical analysis, structural elucidation of the bioactive compound, preclinical test and clinical test etc. So to optimize the time for invention of new drug molecule, computer aided drug designing and molecular docking analysis is being used as one of the highly effective methodology. The phytochemical extraction of Hydnora africana plant was reported to inhibit the growth of Aeromonas hydrophila which cause Septicemia. “Biovia Discovery Studio” molecular docking methods give us opportunity to identify the effective molecule against the microbes. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” recommended that flavone can effectively deactivate the acetaldehyde dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals Bhringraj Derived Phytochemicals against Pneumonia

2020 ◽  
pp. 93-96
Author(s):  
Debajani Tripathy ◽  
Chandana Adhikari ◽  
Mukundjee Pandey ◽  
Dipankar Bhattacharayay
Keyword(s):  
Molecular Docking ◽  
Life Cycle ◽  
Glutamic Acid ◽  
Interaction Energy ◽  
Plant Extract ◽  
Klebsiella Pneumonia ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Phytochemicals from Bhringaraj plant extract are traditionally used to cure Pneumonia. It is caused by Klebsiella pneumonia. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that glutamic acid can effectively deactivate the dehydrogenase enzyme, thereby interrupting the life cycle of the organism.

scholarly journals Capsicum Derived Phytochemicals against Shikimate Dehydrogenase of Haemophilus influenza causing Bronchitis

2020 ◽  
pp. 128-131
Author(s):  
Debesh Kumar Hota ◽  
Debadatta Nayak ◽  
Sitaram Swain ◽  
Dipankar Bhattacharyay
Keyword(s):  
Molecular Docking ◽  
Life Cycle ◽  
Haemophilus Influenzae ◽  
Interaction Energy ◽  
Shikimate Dehydrogenase ◽  
Haemophilus Influenza ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Phytochemicals from Capsicum plant extract are traditionally used to cure Bronchitis. It is caused by Haemophilus influenzae. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Apigenin can effectively deactivate the Shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals Trigonella foenum-graecum Derived Phytochemicals against Cellulitis

2020 ◽  
pp. 93-95
Author(s):  
Bidyashree Tripathy ◽  
Soumya Jal ◽  
Dipankar Bhattacharyay
Keyword(s):  
Molecular Docking ◽  
Streptococcus Pyogenes ◽  
Plant Extract ◽  
Skin Infection ◽  
Discovery Studio ◽  
Trigonella Foenum Graecum ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Cellulitis is a common and sometimes painful bacterial skin infection. Trigonella foenum-graecum extract is traditionally used to cure diseases like cellulitis. Phytochemicals from Trigonella foenum-graecum plant extract can cure Cellulitis. The objective of the study is to identify the phytochemical of Trigonella foenum-graecum capable of curing Cellulitis. Molecular docking method applied using “Biovia Discovery Studio”. “The experiment shows that the phytochemical sarginine, carpaine, choline, gentianine and diosgenin failed to deactivate the UDP-glucose 6-dehydrogenase enzyme of Streptococcus pyogenes for treating Cellulitis.

scholarly journals Alkanna tinctoria Derived Phytochemicals against Staphylococcus aureus Causing Eczema

2020 ◽  
pp. 102-105
Author(s):  
Utapa Nayak ◽  
Elora Barik ◽  
Bijan Kumar Patra ◽  
Smruti Ranjan Behera ◽  
Mukundjee Pandey ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Molecular Docking ◽  
Life Cycle ◽  
Interaction Energy ◽  
Shikimate Dehydrogenase ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Alkanna Tinctoria ◽  
Molecular Docking Method

Alkanna tinctoria plant extract is traditionally used to heal eczema. It is caused by Staphylococcus aureus. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 2-Hydroxy-3-Phenyl-1-4-naphthoquinone can can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals In silico Analysis of Phytochemicals from Cocoa against Ribitol-5-Phosphate 2-Dehydrogenase of Streptococcus pneumoniae Causing Pneumonia

2020 ◽  
pp. 1-5
Author(s):  
Sunanya Das ◽  
Suchismita Khatei ◽  
Saismita Sahoo ◽  
Sitaram Swain ◽  
Dipankar Bhattacharyay
Keyword(s):  
Molecular Docking ◽  
Streptococcus Pneumoniae ◽  
Vanillic Acid ◽  
In Silico ◽  
Metabolic Pathways ◽  
In Silico Analysis ◽  
Discovery Studio ◽  
Dehydrogenase Enzyme ◽  
High Possibility ◽  
Silico Analysis

This analysis aims at evaluating the effects of Cocoa extract on Pneumonia. Pneumonia is caused by Streptococcus pneumoniae. Caffeine, Chorogenic acid, Ferulic acid, Iso- Orientin, luteolin, Naringenin and Vanillic acid of Cocoa were interacted with ribitol-5-phosphate 2-dehydrogenase which is involved in pentose and glucorunate interconversion pathways of Streptococcus pneumoniae. The enzyme was taken as receptor and phytochemicals were considered as ligands. All the interactions were done in Biovia discovery Studio 2020 and the process is known as molecular Docking. Molecular Docking provides us an opportunity to identify the potential phytochemical or component which can act as powerful tool against the pathogen. Out of all the phytochemicals, Luteolin of Cocoa inhibits or blocks the mechanism or action of ribitol-5-phosphate 2-dehydrogenase enzyme of Streptococcus pneumoniae. There is high possibility that these phytochemicals can potentially inhibit others enzymes involved in various metabolic pathways of Streptococcus pneumoniae.

scholarly journals Boswellia serrata Roxb. ex Colebt. Derived Phytochemicals Used in the Treatment of Diarrhea

2020 ◽  
pp. 113-116
Author(s):  
Chinmayee Naik ◽  
Krutanjali Rout ◽  
Mukundjee Pandey ◽  
Ipsita Priyadarsini Samal ◽  
Shibani Sahoo ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Molecular Docking ◽  
Life Cycle ◽  
Alcohol Dehydrogenase ◽  
Interaction Energy ◽  
Boswellia Serrata ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Phytochemicals from Boswellia serrata Roxb. ex Colebt. plant extract are traditionally used to cure diarrhea. It is caused by Escherichia coli. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that p-cymene can effectively deactivate the alcohol dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals Bixa orellana Derived Phytochemicals against Entamoeba histolytica Causing Dysentery

2020 ◽  
pp. 97-100
Author(s):  
Sonali Parida ◽  
Jogesh Kumar Nayak ◽  
Anindita Jena ◽  
Arsia Tabish ◽  
Archita Sahoo ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Life Cycle ◽  
Alcohol Dehydrogenase ◽  
Interaction Energy ◽  
Entamoeba Histolytica ◽  
Bixa Orellana ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Phytochemicals from Bixa orellana plant extract are traditionally used to cure Dysentery. It is caused by Entamoeba histolytica. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that benzoin acid can effectively deactivate the alcohol dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals Buddleja asiatica Lour. Derived Phytochemicals against Staphylococcus aureus Causing Skin Diseases

2020 ◽  
pp. 117-120
Author(s):  
Sasmita Patra ◽  
Sarthak Siddhant Mishra ◽  
Manaranjan Behera ◽  
Ruchi Samparna Sahoo ◽  
Swetanginee Gouda ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Molecular Docking ◽  
Life Cycle ◽  
Lactate Dehydrogenase ◽  
Interaction Energy ◽  
Skin Diseases ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Phytochemicals from Buddleja asiatica plant extract are traditionally used to cure skin diseases. It is caused by Staphylococcus aureus. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that lignoceric acid can effectively deactivate the L-lactate dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals Bixa orellana L. Derived Phytochemicals against Alcohol Dehydrogenase of Escherichia coli

2020 ◽  
pp. 101-104
Author(s):  
Sonali Parida ◽  
Anindita Jena ◽  
Jogesh Kumar Nayak ◽  
Sonali Dash ◽  
Dipankar Bhattacharyay
Keyword(s):  
Escherichia Coli ◽  
Molecular Docking ◽  
Life Cycle ◽  
Alcohol Dehydrogenase ◽  
Benzoic Acid ◽  
Bixa Orellana ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Molecular Docking Method

Phytochemicals from Bixa orellana L. plant extract are traditionally used to cure Jaundice. It is caused by Escherichia coli. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of         -CDOCKER energy and -CDOCKER interaction energy” suggested that benzoic acid can effectively deactivate the alcohol dehydrogenase enzyme thereby interrupting the life cycle of the organism.

scholarly journals Coffea arabica L. Derived Phytochemicals against Haemophilus influenza Causing Conjunctivitis

2020 ◽  
pp. 104-107
Author(s):  
Sutapa Nayak ◽  
Elora Barik ◽  
Biren Pattanayak ◽  
Sitaram Swain ◽  
Dipankar Bhattacharyay
Keyword(s):  
Molecular Docking ◽  
Life Cycle ◽  
Coffea Arabica ◽  
Shikimate Dehydrogenase ◽  
Haemophilus Influenza ◽  
Discovery Studio ◽  
Docking Method ◽  
Dehydrogenase Enzyme ◽  
Coffea Arabica L ◽  
Molecular Docking Method

Phytochemicals from Coffea arabica plant extract are traditionally used to cure conjunctivitis. It is caused by Haemophilus influenza. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that caffeine and chlorogenic acid can efficiently deactivate the shikimate dehydrogenase enzyme which will result in interruption of the life cycle of the microorganism.

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