scholarly journals Improvement of Biomedical Structural Polymers by Synthetic Biology Methods

2021 ◽  
pp. 31-38
Author(s):  
Vyacheslav Gennad'evich Malyutin ◽  
Valentina Olegovna Sevagina ◽  
Viktor Anatolevich Kokotov ◽  
Vitaly V. Goncharov ◽  
Alexander Markov ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Materials Science ◽  
Polymer Materials ◽  
Biological Origin ◽  
New Era ◽  
Continuous Innovation ◽  
Design And Synthesis ◽  
Major Shift ◽  
Near Future ◽  
Structural Polymers

Materials that have a biological origin find many applications in both Biomedicine and other Sciences. However, the properties of these materials are difficult to change, since natural biosynthetic mechanisms are difficult to explain, simulate, or adjust. Thus, many materials of biological origin are isolated from natural tissues or their substitutes are produced recombinantly, and then modified in the process of experimental application. A major shift in this paradigm is caused by the emerging field of synthetic biology, which introduces innovations in the "tool kit" of methods for tuning biomolecules and biosynthetic mechanisms. Relative to materials, this led to higher product titers due to reprogrammed natural biosynthesis and allowed the development of new materials by combining the desired domains. Here we can focus on recent applications of synthetic biology to bio-derived ribosomal and non-ribosomal polymer materials for biomedical applications. It is also interesting to describe modern methods that will affect the production and design of biomaterials in the near future. Continuous innovation at the intersection of synthetic biology and materials science promises to usher in a new era of biomaterial design and synthesis.

Self-healable Functional Polymers based on Diels-Alder ‘Click Chemistry’ Involving Substituted Furan and Triazolinedione Derivatives; A Simple and Very Fast Approach

2021 ◽  
Author(s):  
Prantik Mondal ◽  
Gourhari Jana ◽  
Tuhin Subhra Pal ◽  
Pratim K. Chattaraj ◽  
Nikhil K Singha
Keyword(s):  
Click Chemistry ◽  
Materials Science ◽  
Functional Polymers ◽  
Diels Alder ◽  
Polymer Materials ◽  
Self Healing ◽  
Natural Phenomena ◽  
Science And Engineering ◽  
Fast Approach ◽  
Materials Science And Engineering

Nowadays, the design of functional polymer materials that can mimic natural phenomena, e.g., self-healing of skin cuts, has got a tremendous interest in materials science and engineering. Recently, 1,2,4-triazoline-3,5-dione (TAD)...

scholarly journals A set of experimentally validated, mutually orthogonal primers for combinatorially specifying genetic components

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Subu K Subramanian ◽  
William P Russ ◽  
Rama Ranganathan
Keyword(s):  
Synthetic Biology ◽  
High Throughput ◽  
Dna Sequences ◽  
Gene Synthesis ◽  
Modular Architecture ◽  
Design And Synthesis ◽  
Genetic Components ◽  
Polymerase Chain ◽  
Polymerase Chain Reaction Primers ◽  
Microarray Chips

Abstract The design and synthesis of novel genes and deoxyribonucleic acid (DNA) sequences is a central technique in synthetic biology. Current methods of high throughput gene synthesis use pooled oligonucleotides obtained from custom-designed DNA microarray chips, and rely on orthogonal (non-interacting) polymerase chain reaction primers to specifically de-multiplex, by amplification, the precise subset of oligonucleotides necessary to assemble a full length gene. The availability of a large validated set of mutually orthogonal primers is therefore a crucial reagent for high-throughput gene synthesis. Here, we present a set of 166 20-nucleotide primers that are experimentally verified to be non-interacting, capable of specifying 13 695 unique genes. These primers represent a valuable resource to the synthetic biology community for specifying genetic components that can be assembled through a scalable and modular architecture.

Cell-free synthetic biology in the new era of enzyme engineering

2020 ◽  
Vol 28 (11) ◽  
pp. 2810-2816
Author(s):  
Nan Jiang ◽  
Lianju Ma ◽  
Yuan Lu
Keyword(s):  
Synthetic Biology ◽  
Enzyme Engineering ◽  
New Era

Polymer Materials Science.

1974 ◽  
Vol 7 (1) ◽  
pp. 83
Author(s):  
Garth L. Wilkes
Keyword(s):  
Materials Science ◽  
Polymer Materials

A New Era in Ocean Policy

1997 ◽  
Vol 12 (1) ◽  
pp. 1-4
Author(s):  
Claiborne Pell
Keyword(s):  
Foreign Relations ◽  
New Era ◽  
Ocean Policy ◽  
The Us ◽  
Short Piece ◽  
Us Senate ◽  
Near Future

AbstractIn this short piece, Senator Pell, veteran of the US Senate Foreign Relations Committee, sets out the multiplicity of interests which would be protected if the US were to accede, in the near future, to the 1982 LOS Convention.

Polymer Materials Science: Novel Synthesis and Characterization of Supermolecular Structures

MRS Bulletin ◽  
1991 ◽  
Vol 16 (7) ◽  
pp. 20-22
Author(s):  
Curtis W. Frank
Keyword(s):  
Polymer Films ◽  
Evanescent Wave ◽  
Materials Science ◽  
Supermolecular Structure ◽  
Genetically Engineered ◽  
Polymer Materials ◽  
Molecular Organization ◽  
Optical Methods ◽  
Restricted Geometry

The two feature articles in this issue present numerous contrasts, but both reflect the vitality of research in polymer science today. David Tirrell and co-authors paint a picture of how the techniques of molecular biology may be applied to the synthesis of novel “proteinlike” polymers with control over molecular weight, composition, and stereoregularity that is unprecedented in the realm of traditional polymer chemistry. Wolfgang Knoll turns his attention to ultrathin polymer films with thicknesses comparable to molecular chain dimensions and demonstrates how evanescent wave optical methods may be used to provide spectroscopic as well as imaging information on the characterization of these “restricted geometry” systems.Both authors address the issue of supermolecular structure, whether approached from the synthetic or physical chemical viewpoints. Tirrell describes a series of target polymers, expressed by genetically engineered microorganisms, which may provide a fundamental understanding and control over chain folding, a critical morphological feature governing solid-state behavior of synthetic polymers. Knoll analyzes the fundamentals of evanescent wave optical methods for interrogating the molecular organization in polymer films that have considerable potential in electronic or photonic applications.

scholarly journals Systems Biology and Synthetic Biology: A New Epoch for Toxicology Research

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Mark T. Mc Auley ◽  
Hyunok Choi ◽  
Kathleen Mooney ◽  
Emily Paul ◽  
Veronica M. Miller
Keyword(s):  
Systems Biology ◽  
Synthetic Biology ◽  
Aromatic Hydrocarbons ◽  
Personalised Medicine ◽  
Adverse Birth Outcomes ◽  
New Era ◽  
Advantages And Disadvantages ◽  
The Future ◽  
Polycyclic Aromatic ◽  
Innovative Techniques

Systems biology and synthetic biology are emerging disciplines which are becoming increasingly utilised in several areas of bioscience. Toxicology is beginning to benefit from systems biology and we suggest in the future that is will also benefit from synthetic biology. Thus, a new era is on the horizon. This review illustrates how a suite of innovative techniques and tools can be applied to understanding complex health and toxicology issues. We review limitations confronted by the traditional computational approaches to toxicology and epidemiology research, using polycyclic aromatic hydrocarbons (PAHs) and their effects on adverse birth outcomes as an illustrative example. We introduce how systems toxicology (and their subdisciplines, genomic, proteomic, and metabolomic toxicology) will help to overcome such limitations. In particular, we discuss the advantages and disadvantages of mathematical frameworks that computationally represent biological systems. Finally, we discuss the nascent discipline of synthetic biology and highlight relevant toxicological centred applications of this technique, including improvements in personalised medicine. We conclude this review by presenting a number of opportunities and challenges that could shape the future of these rapidly evolving disciplines.

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