scholarly journals Surgical Outcome of Hirschsprung’s Disease in Male Child: A Rare Case Report

Author(s):  
Pallavi Dhole

Introduction: This disorder characterized by absence of particular nerve cells (ganglions) in a segment of the bowel in an infant. Ganglion cell absence allows the muscles of the intestines to lose their capacity to pass faeces across the peristalsis of the intestine. This condition affects the large intestine and causes problem with passing stool. The condition is congenital. In around 1 out of 5000 live births, Hirschsprung disease occurs and is three times more frequent in boys than girls. About 12% of cases are due to genetic disorders. Patient history: A 2 years old male was admitted in A.V.B.R. Hospital in paediatric ward. His chief complaint was inability to pass stools on his own, fever, vomiting, constipation. Paediatric history: This male child was born by Lower segment caesarean section. At the age of 17 months, the complaint started with inability to pass stool on his own. After that his parents approached A.V.B.R. Hospital and Doctor advised for further medical and surgical management. Main symptoms and importance of clinical findings: The patient had undergone various investigations like blood tests, USG, Physical examination and. rectal biopsy and per abdominal x-ray. Medical Management: Patient was treated with trans-anal endorectal pull through surgery under general anaesthesia Nursing management: Administered fluid replacement i.e. DNS and RL, monitored all vital signs checked 8 hourly. Conclusion: The 2 years old male was admitted in A.V.B.R. Hospital in paediatric ward. His chief complaint was inability to pass stools on his own, fever, vomiting, constipation etc. after undergoing investigation he was diagnosed as Hirschsprung’s disease.

2010 ◽  
Vol 20 (02) ◽  
pp. 95-97 ◽  
Author(s):  
N. Rahman ◽  
J. Chouhan ◽  
S. Gould ◽  
Vt. Joseph ◽  
H. Grant ◽  
...  

2003 ◽  
Vol 38 (3) ◽  
pp. 412-416 ◽  
Author(s):  
Nicola A. Lewis ◽  
Marc A. Levitt ◽  
Garret S. Zallen ◽  
Mona S. Zafar ◽  
Karen L. Iacono ◽  
...  

2021 ◽  
Vol 10 (2) ◽  
pp. 104-113
Author(s):  
Md Benzamin ◽  
Md Rukunuzzaman ◽  
Md Wahiduzzaman Mazumder ◽  
ASM Bazlul Karim

Hirschsprung’s disease (HD) is a rare genetic congenital defect of intestine causing failure of migration of parasympathetic ganglionic cells in some definite part of intestine, resulting in functional intestinal obstruction. It commonly involves rectosigmoid region of colon but other parts of colon or total colon, even small intestine may be affected. Incidence is 1/5000 live births. It is one of the common pediatric surgical problems and 2nd most organic cause of constipation. Symptoms may be evident from 1st day of life. About 90% infants with Hirschprung’s disease fail to pass meconium in 1st 24 hours of life. About 80% HD cases are diagnosed in early few months of life and present with abdominal distention, constipation, poor feeding, vomiting etc. HD enterocolitis is a devastating condition related to mortality. HD may be associated with some congenital anomalies and syndrome. High index of suspicion is the main key to diagnosis. Radiological investigation supports the diagnosis and rectal biopsy for histopathology is confirmatory. Although it is a surgical problem, physician can play a key role in early diagnosis and thus help to prevent HD enterocolitis-related mortality and restore near-normal life. J Enam Med Col 2020; 10(2): 104-113


2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Emilie G. Jaroy ◽  
Lourdes Acosta-Jimenez ◽  
Ryo Hotta ◽  
Allan M. Goldstein ◽  
Ragnhild Emblem ◽  
...  

Abstract Hirschsprung disease is a neurocristopathy, characterized by aganglionosis in the distal bowel. It is caused by failure of the enteric nervous system progenitors to migrate, proliferate, and differentiate in the gut. Development of an enteric nervous system is a tightly regulated process. Both the neural crest cells and the surrounding environment are regulated by different genes, signaling pathways, and morphogens. For this process to be successful, the timing of gene expression is crucial. Hence, alterations in expression of genes specific for the enteric nervous system may contribute to the pathogenesis of Hirschsprung’s disease. Several epigenetic mechanisms contribute to regulate gene expression, such as modifications of DNA and RNA, histone modifications, and microRNAs. Here, we review the current knowledge of epigenetic and epitranscriptomic regulation in the development of the enteric nervous system and its potential significance for the pathogenesis of Hirschsprung’s disease. We also discuss possible future therapies and how targeting epigenetic and epitranscriptomic mechanisms may open new avenues for novel treatment.


2014 ◽  
Vol 10 (2) ◽  
pp. 42-45
Author(s):  
Kayode T. Bamigbola ◽  
Abdulrasheed A. Nasir ◽  
Lukman O. Abdur-Rahman ◽  
Adewale O. Oyinloye ◽  
Nurudeen T. Abdulraheem ◽  
...  

2018 ◽  
Vol 53 (10) ◽  
pp. 1942-1944 ◽  
Author(s):  
Niels Bjørn ◽  
Lars Rasmussen ◽  
Niels Qvist ◽  
Sönke Detlefsen ◽  
Mark Bremholm Ellebæk

2020 ◽  
Vol 8 (11) ◽  
pp. 2520-2523
Author(s):  
Abdus Sattar ◽  
Mahfuzul Haque ◽  
Arun Kanti Paul ◽  
Ruhul Quddus

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