scholarly journals Correlation of p53 Immunoexpression with Depth of Tumor in Microinvasive Oral Squamous Cell Carcinoma

2021 ◽  
pp. 98-103
Author(s):  
Archana Sonone ◽  
Swati Patil ◽  
Alka Hande ◽  
Madhuri Gawande
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Connective Tissue ◽  
Basement Membrane ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Protocol ◽  
Depth Of Invasion ◽  
Histological Grading ◽  
Neoplastic Cells

Introduction: “Oral squamous cell carcinoma (OSCC)” is a major health issue in India, the incidence of OSCC is 3-7 times more in developing countries than developed countries. OSCC is the ‘3rd most common cancer’ in India followed by “cervical and breast cancer”. One side  of OSCC that  has not much explore is the ‘microinvasive squamous cell carcinoma’ which is an early stage neoplasm  without infiltration in the deeper tissues. There is no particular definition of “microinvasive oral squamous cell carcinoma (MIOSCC)” There are no specific guideline are present to categories the “microinvasive squamous cell carcinoma (MIOSCC)”. Most of the time the infiltrating neoplastic cells are masked under the background of the inflammatory cell infiltrate present connective tissue stroma. So this study is humble attempt to recognized and measured depth of invasion of infiltrative neoplastic cells to categories MIOSCC and to find better management protocol for it Aim: This study aims to: Measure p53 immunoexpression  in “microinvasive oral squamous cell carcinoma, evaluate the depth of invasion in MIOSCC  in H & E stained section, and correlate the  p53 immunoexpression with  the depth of tumor in it. Methodology: The  25 cases of  “microinvasive oral squamous cell carcinoma” will be selected  and 10 cases of “normal oral mucosa (NOM)” will be   obtained from “gingiva and vestibular mucosa” as controls  after extraction of impacted teeth. “The depth of tumor”  will  be measured from the “basement membrane or in areas of basement membrane loss, from an imaginary line reconstructing the basement membrane from the adjacent epithelium to the deepest point of invasion in connective tissue” by  Leica DMLB2 research microscope with Leica Q-win standard software (Switzerland). Results: The results  show that   the depth of invasion in MIOSCC, will be  categorized the lesion and give the better guidelines for histological grading and treatment protocol for MIOSCC Conclusion: There are no definite guidelines for histological grading and final treatment protocol for MIOSCC. The assessments of depth of tumor through p53 immunoexpression may be one of the criteria for grading in MIOSCC. Thus the correlation of p53 immunoexpression with the depth of tumor in MIOSCC helps to determine the treatment modalities of MIOSCC.

Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: A meta‐analysis

Oral Diseases ◽  
2019 ◽  
Vol 26 (7) ◽  
pp. 1357-1365 ◽  
Author(s):  
Patrícia Carlos Caldeira ◽  
Andrea María López Soto ◽  
Maria Cássia Ferreira Aguiar ◽  
Carolina Castro Martins
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Meta Analysis ◽  
Depth Of Invasion ◽  
Tumor Depth

scholarly journals Intraoral Ultrasound in the Evaluation of Depth of Invasion in OSCC. Preliminary Results

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 28
Author(s):  
Graniero ◽  
D’Alessandro ◽  
Montori ◽  
Rocchetti ◽  
Cantisani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphatic Spread ◽  
Depth Of Invasion ◽  
Preliminary Results

Oral Squamous Cell Carcinoma (OSCC) shows an early tendency to lymphatic spread rather than hematogenous. The surgical treatment cannot be considered oncologically complete if the neck is not evaluated [1]. [...]

scholarly journals Progressive Extracellular Matrix Disorganization in Chemically Induced Murine Oral Squamous Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
B. Fuentes ◽  
J. Duaso ◽  
D. Droguett ◽  
C. Castillo ◽  
W. Donoso ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Connective Tissue ◽  
Cell Carcinoma ◽  
Basal Lamina ◽  
Squamous Cell ◽  
Collagen I ◽  
Severe Dysplasia ◽  
Tumor Pathogenesis

Introduction. Oral squamous cell carcinoma (OSCC) is one of the ten most common cancers affecting the human population. Tumor pathogenesis implies a multistep process in which cells acquire features that enable them to become tumorigenic and ultimately malignant. The process of OSCC carcinogenesis can be reproduced in animal models, the OSCC induction with 4-nitroquinoline-1-oxide (4NQO) in mice is a widely used tool for studying tumor pathogenesis. Objective. The aim of the present study was to determine the progressive changes in basal lamina and connective tissue remodeling during 4NQO-induced OSCC carcinogenesis. Material and Methods. Samples were classified according to “International Histological Classification of tumors” in mild, moderate, and severe dysplasia and invasive carcinoma. Five samples of each pathologic entity and control healthy tongues were used. Immunohistochemical analysis of collagen IV as well as histochemical analysis of glycosylated molecules (PAS) and collagen I (Picro Sirius red) were performed. Results. During experimental-induced carcinogenesis by 4NQO a progressive basal lamina destruction and collagen I disorganization in adjacent connective tissue can be observed. Conclusion. Our results confirm previous studies that show alterations in extracellular matrix (ECM) in malignant lesions, validating the experimental carcinogenesis induced by 4NQO.

Oral Squamous Cell Carcinoma: A Clinicopathological Study of 342 Thai Cases

2009 ◽  
Vol 10 (5) ◽  
pp. 33-41 ◽  
Author(s):  
Robert P. Langlais ◽  
Aree Jainkittivong ◽  
Somporn Swasdison ◽  
Malee Thangpisityotin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Age At Diagnosis ◽  
Care Providers ◽  
Histological Grading ◽  
Female Ratio ◽  
Dental Practitioners ◽  
Clinicopathological Study

Abstract Aim To conduct a clinicopathological review of oral squamous cell carcinoma (SCC) and to analyze it with respect to gender, age at diagnosis, clinical presentation, lesion location, and histological grading. Methods and Materials Information on the clinicopathological characteristics of SCC was obtained from pathology reports of 342 cases. Results The male to female ratio was 1:1 and the incidence increased with age. Among the patients 4.7% were younger than 40 years and males were predominant in this subgroup. The alveolar ridge and gingiva were the most commonly affected sites (50%). The majority of the SCC cases presented as ulcers or masses. Swelling and/or pain were the first signs and/ or symptoms in most patients (52.6%). The age at diagnosis in relation to the site of occurrence varied. Conventional SCC was the most common subtype (88%). Well-differentiated SCC was the most common histological grading (78.6%). Conclusion In the present study, the incidence of SCC was age-related and showed equal gender distribution. Clinical Significance Routine examination of the oral cavity by dental practitioners and other health care providers aids in the early detection of premalignant and malignant oral disease. Dentists can play a significant role in disseminating information regarding oral cancer. Citation Jainkittivong A, Swasdison S, Thangpisityotin M, Lnaglais RP. Oral Squamous Cell Carcinoma: A Clinicopathological study of 342 Thai Cases. J Contemp Dent Pract [Internet]. 2009 Sept; 10(5). Available from: http://www.thejcdp. com/journal/view/oralsquamous-cell-carcinoma-aclinicopathological- study-of-342-thai-cases.

Sign in / Sign up

Export Citation Format

Share Document