scholarly journals Diagnostic Role of Dopplerography of Renal Vessels in Patients with Late Dysfunction of the Transplanted Kidney

2021 ◽  
pp. 203-208
Author(s):  
Yakymenko Volodymyr Viktorovych
Keyword(s):  
Blood Flow ◽  
Kidney Transplantation ◽  
Renal Transplant ◽  
Glomerular Filtration ◽  
Non Invasive ◽  
Transplanted Kidney ◽  
Renal Vessels ◽  
Diagnostic Role ◽  
Cadaveric Kidney

Aims: Search for non-invasive methods for diagnosing late transplant kidney dysfunction, which can improve control and monitor the condition of the kidney transplant, characterization diagnostic role of dopplerography of renal vessels in patients with late dysfunction of the transplanted kidney. Study design:  When conducting dopplerometry, blood flow indices were analyzed from 3 to 6 cycles of heart contractions, followed by an averaged indicator. In addition, the linear blood flow velocity was assessed separately from the renal vein. Place and Duration of Study: For the period 2016-2017 Ultrasound of an allopod was performed in 60 recipients of RT (RENAL TRANSPLANT) in the late postoperative period. Methodology: The average age of the patients was 38.89 ± 1.52 years. There were 34 men (56.6 7%), 26 women (43.33%). All patients were divided into two groups: patients with preserved function and patients with RT (RENAL TRANSPLANT) dysfunction. Related kidney transplantation (RRT) was performed in 55.0% of patients, in 45.0% - cadaveric kidney transplantation (CKP). The groups were comparable in the main clinical and demographic parameters. Results: The reverse dynamics was observed when examining the level of the renal filtration function indicator, the estimated glomerular filtration rate (SKF) - at a TAMX level of more than 15 cm/sec, glomerular filtration was 51.18 ± 1.93 (47.32-55.04) ml/min (p <0.01), and with a decrease in TAMX of less than 15 cm/sec, the level of SKF decreased significantly, more than twice, to the level of 25.40 ± 2.19 (21.02-29.78) ml/min <0.001). Conclusion: The determination of dopplerographic parameters for TP with preserved and especially with impaired depuration function with a direct assessment of TAMX opens up wide opportunities in non-invasive assessment of RT (RENAL TRANSPLANT) changes, identification of developing complications, as well as improved transplant survival.

scholarly journals Captopril-induced fall in glomerular filtration rate in cyclosporine-treated hypertensive patients.

1993 ◽  
Vol 3 (9) ◽  
pp. 1570-1574
Author(s):  
J J Curtis ◽  
D A Laskow ◽  
P A Jones ◽  
B A Julian ◽  
R S Gaston ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Glomerular Filtration Rate ◽  
Renal Transplant ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Blood Levels ◽  
Hypertensive Patients ◽  
Transplant Patients ◽  
Renal Transplant Patients

It was found that two known renal vasodilators had different effects on RBF and GFR in the setting of therapeutic blood levels of cyclosporine in hypertensive renal transplant patients. Captopril lowered blood pressure in these patients but also lowered blood flow and GFR. Nifedipine lowered blood pressure to the same degree but without lowering either RBF or GFR.

scholarly journals The Diagnostic Role of Urinary N-Acetyl-β-D-glucosaminidase (NAG) Activity in the Detection of Renal Tubular Impairment

2005 ◽  
Vol 48 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Sylva Skálová
Keyword(s):  
Renal Damage ◽  
Perinatal Asphyxia ◽  
Non Invasive ◽  
Diagnostic Role ◽  
Invasive Method ◽  
Nephrotoxic Drugs ◽  
Renal Tubular

The kidney function can be assessed by a number of methods. The urinary excretion of enzymes, in particular N-acetyl-β-D-glucosaminidase (NAG), is considered a relatively simple, cheap, fast and non-invasive method in the detection and follow-up of renal tubular function under various conditions. The determination of urinary NAG provides a very sensitive and reliable indicator of renal damage, such as injury or dysfunction due to diabetes mellitus, nephrotic syndrome, inflammation, vesicoureteral reflux, urinary tract infection, hypercalciuria, urolithiasis, nephrocalcinosis, perinatal asphyxia, hypoxia, hypertension, heavy metals poisoning, treatment with aminoglycosides, valproate, or other nephrotoxic drugs. This paper gives an overview of the current use of urinary NAG in the detection of renal injury.

The Role of Time in Health IoT

2017 ◽  
pp. 197-213
Author(s):  
Lambert Spaanenburg
Keyword(s):  
Blood Flow ◽  
Network Architecture ◽  
Blood Pressure Measurement ◽  
The Body ◽  
New Device ◽  
Non Invasive ◽  
Body Change ◽  
Level Model ◽  
Multi Level

As the biological processes in the body change constantly, comparable measurements should be taken simultaneously in time and place. In practice, this is hard to achieve. Synchronicity is required to certify medical accuracy for a new device by reference to a certified one. In a typical health IoT, synchronicity cannot be enforced procedurally and timing needs to be part of the network architecture. Popular examples are in blood pressure measurement. Putting the blood flow in a known pinch-off situation performs synchronization. But this principle cannot be extended to other non-invasive measurements. Hence the chapter proposes to synchronize on basis of the heart rate extracted from the blood flow at arbitrary positions on the body. This models the blood flow in the body and relates all to the rhythm of the heart. It brings existing phenomena into a single, multi-level model that allows wireless networked wearables into a single health-monitoring scheme.

scholarly journals The Role of HLA Tissue Matching in Cadaveric Kidney Transplantation

1979 ◽  
Vol 189 (5) ◽  
pp. 581-586 ◽  
Author(s):  
ROBERT E. RICHIE ◽  
H. K. JOHNSON ◽  
M. B. TALLENT ◽  
BRUCE TURNER ◽  
WILLIAM VAUGHN ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Cadaveric Kidney ◽  
Cadaveric Kidney Transplantation

scholarly journals Renal blood flow and oxygenation drive nephron progenitor differentiation

2014 ◽  
Vol 307 (3) ◽  
pp. F337-F345 ◽  
Author(s):  
Christopher Rymer ◽  
Jose Paredes ◽  
Kimmo Halt ◽  
Caitlin Schaefer ◽  
John Wiersch ◽  
...  
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Kidney Development ◽  
De Novo ◽  
Nephron Progenitors ◽  
Renal Vessels ◽  
Nephron Differentiation ◽  
Nephron Progenitor ◽  
Nephrogenic Zone

During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. In the present study, we investigated the regulatory role of renal blood flow and O2 concentration on nephron progenitor differentiation during ontogeny. To elucidate the presence of blood flow, ultrasound-guided intracardiac microinjection was performed, and FITC-tagged tomato lectin was perfused through the embryo. Kidneys were costained for the vasculature, ureteric epithelium, nephron progenitors, and nephron structures. We also analyzed nephron differentiation in normoxia compared with hypoxia. At embryonic day 13.5 (E13.5), the major vascular branches were perfused; however, smaller-caliber peripheral vessels remained unperfused. By E15.5, peripheral vessels started to be perfused as well as glomeruli. While the interior kidney vessels were perfused, the peripheral vessels (nephrogenic zone) remained unperfused. Directly adjacent and internal to the nephrogenic zone, we found differentiated nephron structures surrounded and infiltrated by perfused vessels. Furthermore, we determined that at low O2 concentration, little nephron progenitor differentiation was observed; at higher O2 concentrations, more differentiation of the nephron progenitors was induced. The formation of the developing renal vessels occurs before the onset of blood flow. Furthermore, renal blood flow and oxygenation are critical for nephron progenitor differentiation.

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