Association of Mean Platelet Volume (MPV) in Relation to Disease Activity in Lupus

Introduction: Among the various clinical and biochemical parameters which are employed to monitor the disease activity in Systemic Lupus Erythematosus (SLE), Mean Platelet Volume, which is a platelet activation biomarker has been recently studied. We intended at evaluating the MPV in patients with active SLE and comparing it with the same patients who were in clinical remission, and to study the correlation between MPV and SLEDAI. We also studied the correlation between MPV and ESR, complements C3 and C4. Methods: This is a prospective study conducted for a period of 12 months, in which 50 consecutive patients who were recently diagnosed with SLE according to the SLICC classification criteria were included. Complete blood count with MPV levels along with ESR, were measured at the first visit to the hospital and were repeated at every visit till they attained clinical remission. Analysis of MPV was done at first visit and at remission. Complements C3 and C4 was done at the first visit and at remission. The results were then tabulated and statistically analysed using SPSS 25. A Pearson’s correlation test was done to assess the relation between MPV, ESR and SLEDAI. Results: Patients with active disease had a decreased MPV as compared to those in clinical remission (10.91fl, 13.11fl, p=0.011). We observed a weak positive correlation between MPV and SLEDAI (r=0.034, p=0.011). We observed no correlation between MPV and ESR, C3 and C4. Meanwhile, SLEDAI showed a positive correlation with C3 and C4; there was no correlation with ESR though. Conclusion: MPV is reduced in patients with active SLE and displayed an inverse correlation with SLEDAI.

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

F1000Research ◽

10.12688/f1000research.10763.3 ◽

2017 ◽

Vol 6 ◽

pp. 126 ◽

Cited By ~ 3

Author(s):

Abidullah Khan ◽

Iqbal Haider ◽

Maimoona Ayub ◽

Salman Khan

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Sampling Technique ◽

Cross Sectional Study ◽

Strong Positive Correlation ◽

Platelet Volume ◽

Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (rs= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (rs=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

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Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

Journal of Rheumatic Diseases ◽

10.4078/jrd.2017.24.5.279 ◽

2017 ◽

Vol 24 (5) ◽

pp. 279 ◽

Cited By ~ 3

Author(s):

Young Ho Lee ◽

Gwan Gyu Song

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Meta Analysis ◽

Systemic Lupus Erythematosus Disease ◽

Systemic Lupus ◽

Platelet Volume ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

F1000Research ◽

10.12688/f1000research.10763.2 ◽

2017 ◽

Vol 6 ◽

pp. 126 ◽

Cited By ~ 5

Author(s):

Abidullah Khan ◽

Iqbal Haider ◽

Maimoona Ayub ◽

Salman Khan

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Sampling Technique ◽

Cross Sectional Study ◽

Strong Positive Correlation ◽

Platelet Volume ◽

Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant (P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r= -0.94, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r=0.95, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% (P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

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Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

The Open Rheumatology Journal ◽

10.2174/1874312901812010129 ◽

2018 ◽

Vol 12 (1) ◽

pp. 129-138 ◽

Cited By ~ 2

Author(s):

Lisandra Torres Hartmann ◽

Ana Paula Alegretti ◽

Alice Beatriz Mombach Pinheiro Machado ◽

Eduardo Ferreira Martins ◽

Rafael Mendonça da Silva Chakr ◽

...

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Inactive Disease ◽

Control Group ◽

Platelet Volume ◽

Complement Components ◽

Cross Sectional

Introduction: The Mean Platelet Volume (MPV) is a platelet activation biomarker that has been recently correlated with disease activity in SLE. We aimed to evaluate the MPV in patients with SLE comparing it with healthy individuals, to study the correlation between MPV and SLE Disease Activity Index (SLEDAI) in SLE patients and to analyze possible correlation between MPV and Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and complement components C3 and C4. Methods: This is a cross-sectional study in which 81 patients with SLE according to the American College of Rheumatology (ACR) diagnostic classification criteria and 58 healthy controls were included. Active disease was defined as SLEDAI>0. Results: Patients with active SLE had decreased MPV when compared to inactive disease group (10.0±0.7fL vs. 10.7±1.0fL, p=0.005, respectively) and when compared to control group (10.9±1.0fL, p<0.001). Our study found a weak negative correlation between the SLEDAI and the MPV (r=-0.29, p=0.009). There was no correlation between MPV and CRP, ESR, C3 and C4. Also, no correlation between SLEDAI and CRP, ESR, C3 and C4 was found. Conclusion: MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.

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