Utility of Microvessel Density (MVD) by CD34 in Different Histological Grades of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma is one of the leading causes of cancer related death and is preventable. Different grade at which a carcinoma presents determines the treatment modality and prognosis of the disease. Microvessel density measures formation of new vessels around tumor mass and is very important criteria for tumor metastasis and disease spread. Immunohistochemistry provide very definitive measures to determine the micro vessel density. Our study showed a positive correlation between Microvessel density and tumor size and dysplasia.

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Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma

Tumor Biology ◽

10.1007/s13277-015-3735-1 ◽

2015 ◽

Vol 36 (12) ◽

pp. 9717-9722 ◽

Cited By ~ 7

Author(s):

Marina Gonçalves Diniz ◽

Jeane de Fatima Correia Silva ◽

Fabricio Tinôco Alvim de Souza ◽

Núbia Braga Pereira ◽

Carolina Cavaliéri Gomes ◽

...

Keyword(s):

Cell Cycle ◽

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Gene Transcription ◽

Squamous Cell ◽

Tumor Size ◽

Cell Cycle Gene

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Multi-Region Sequence Analysis of a Pregnancy-Related Oral Squamous Cell Carcinoma Exhibiting Low-Level Aggressive Behavior

International Journal of Surgical Pathology ◽

10.1177/1066896919876058 ◽

2019 ◽

Vol 28 (2) ◽

pp. 188-195

Author(s):

Davide Bartolomeo Gissi ◽

Andrea Gabusi ◽

Achille Tarsitano ◽

Roberto Rossi ◽

Tiziana Balbi ◽

...

Keyword(s):

Dna Methylation ◽

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Aggressive Behavior ◽

Cell Carcinoma ◽

Squamous Cell ◽

Field Cancerization ◽

Tumor Mass ◽

Dna Mutation ◽

Low Level

We analyzed the genetic and epigenetic profiles of an oral squamous cell carcinoma affecting a 41-year-old pregnant female. The patient presented with an oral mass located at the hard and soft palate with bone involvement and lymph node metastases (T4N1M0). She had been treated with multimodal radiotherapy and chemotherapy, and she is currently alive with no evidence of disease 8 years after treatment. DNA methylation and DNA mutation analyses were used to analyze multiple samples from the tumor mass and from the non-neoplastic mucosa to verify tumor heterogeneity. Genetic and epigenetic analyses revealed the presence of one shared TP53 driver mutation with the same DNA methylation profile in each of the 3 areas of the tumor mass; only 2 additional passenger mutations were detected, suggesting a simple clonal homogeneous carcinoma, which usually is associated with low-level aggressive behavior. Additionally, no genetic or epigenetic alteration in the non-neoplastic oral mucosa was detected, demonstrating the absence of field cancerization. The low aggressiveness of the lesion was confirmed by the patient being free of disease at a long-term follow-up examination. These data suggest a different molecular transformation pathway in pregnancy-related oral squamous cell carcinomas, providing new perspectives for further investigation.

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