scholarly journals Theophylline Derivatives' In-vivo Analgesic and Anti-Inflammatory Activities

2021 ◽  
pp. 144-152
Author(s):  
Faruk Alam ◽  
Ruhul Amin ◽  
Biplab Kumar Dey ◽  
Josef Yakin ◽  
Smriti Rekha Chanda Das ◽  
...  
Keyword(s):  
Spectral Data ◽  
Aromatic Aldehyde ◽  
Acetyl Chloride ◽  
Ammonium Thiocyanate ◽  
Experimental Results ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Theophylline Derivatives

The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substituted theophylline derivatives (3A-3D), followed by ammonium thiocyanate and substituted aromatic aldehyde, and these synthesized derivatives were screened to study their analgesic and anti-inflammatory activities. UV, IR, H-1 NMR, mass spectral data, and CHN activities were used to describe the compounds, which were shown to be considerably efficacious at 100 mg/kg p.o., as well as experimental results that were statistically significant at the p <0.01 and p <0.05 levels.

scholarly journals Microwave Assisted Synthesis and Characterization of Schiff Base of 2-Amino Benzimidazole

2018 ◽  
Vol 10 (4) ◽  
Author(s):  
Garima Shrivastava ◽  
Manjul Shrivastava
Keyword(s):  
Schiff Base ◽  
Spectral Data ◽  
Aromatic Aldehyde ◽  
Synthesis And Characterization ◽  
Microwave Assisted Synthesis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted

New Schiff base (2-[(1H-benzimidazol-2-ylimino) methyl]-4,6- diiodophenol) was synthesized by the condensation of aryl/hetero aromatic aldehyde (3,5diiodosalicylaldehyde) with 2- amino benzimidazole under conventional and microwave conditions and characterized through IR, HNMR and Mass spectral data and CHN analysis

scholarly journals Quinazoline-containing Hydrazydes of Dicarboxylic Acids and Products of Their Structural Modification: A Novel Class of Anti-inflammatory Agents

2021 ◽  
Vol 68 (2) ◽  
pp. 395-403
Author(s):  
Nataliia Krasovska ◽  
Viktor Stavytskyi ◽  
Inna Nosulenko ◽  
Oleksandr Karpenko ◽  
Oleksii Voskoboinik ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Spectral Data ◽  
1H Nmr ◽  
Structural Modification ◽  
Dicarboxylic Acids ◽  
Inflammatory Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Amide Fragment

The synthesis of hydrazides formed by quinazolin-4(3H)-ylidenehydrazine and dicarboxylic acids, as well as their further modification are described in the present manuscript. It was shown that above-mentioned hydrazides may be obtained via acylation of initial quinazolin-4(3H)-ylidenehydrazine by corresponding acylhalides, cyclic anhydrides and imidazolides of dicarboxylic acids monoesters. Obtained hydrazides were converted into [1,2,4]triazolo[1,5-с]quinazolines that were used as initial compounds for chemical modification aimed to the introduction of amide fragment to the molecule. The IR, 1H NMR and chromato-mass spectral data of obtained compounds were studied and discussed. Obtained substances were studied for anti-inflammatory activity using carrageenan-induced paw inflammation model. Amides of ([1,2,4]triazolo[1,5-с]quinazoline-2-yl)alkyl carboxylic acids were detected as promising class of anti-inflammatory agents for further purposeful synthesis and profound study of anti-inflammatory activity.

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

INDIAN DRUGS ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 40-44
Author(s):  
.Aishwarya T.C ◽  
◽  
James Jainey ◽  
Vijay Kumar M. ◽  
B.C. Revanasiddappa
Keyword(s):  
Spectral Data ◽  
Anticonvulsant Activity ◽  
Aromatic Aldehydes ◽  
Oxidative Cyclization ◽  
Mercuric Oxide ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Oxadiazole Derivatives

2 Oxo-2h-chromene-3-carbohydrazide (1) reacts with various aromatic aldehydes to give corresponding 2-oxo-2h-chromene-3-carbohydrazide arylidene hydrazides (SB1-8). Oxidative cyclization of (SB1-8) with mercuric oxide and iodine in DMF medium furnishes the title compounds 3-(5-aryl-1,3,4-oxadiazol2-yl)-2h-chromen-2-ones (2a-h). All the synthesized compounds were assigned structures on the basis of IR, 1 H-NMR and Mass spectral data. Some of the selected compounds were evaluated for In vivo anticonvulsant activity by MES and PTZ models.

scholarly journals Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4 (3H)-ones

2009 ◽  
Vol 6 (4) ◽  
pp. 1055-1062 ◽  
Author(s):  
Manish Srivastav ◽  
MD. Salahuddin ◽  
S. M. Shantakumar
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Inflammatory Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Substituted 1 ◽  
Amino Benzoic Acid

A series of novel 3-(6-substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4(3H)-ones were synthesized by treating 2-(chloromethyl)-3-(6-substituted-1, 3-benzothiazole-2-yl) quinazoline-4-(3H)-one (IIa-d) with various substituted amine. The compounds (IIa-d) prepared by treating 2-[(chloroacetyl) amino] benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inflammatory and antibacterial activity.

scholarly journals SYNTHESIS OF SOME NEW PRODRUGS OF SULPHONAMIDES AND STUDIES ON THEIR ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTION

2002 ◽  
Vol 70 (3) ◽  
pp. 277-286 ◽  
Author(s):  
Khan M.S.Y. ◽  
Husain A. ◽  
Hasan S.M. ◽  
Akhter M.
Keyword(s):  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Significant Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Inflammatory Action

Various amide-based prodrugs of sulphonamides have been synthesised by condensing appropriate sulphonamide moiety with different β-aroyl propionic acids. All the compounds have been evaluated for their antimicrobial and anti-inflammatory activities. Their structures were established on the basis of elemental analysis, 1H NMR and Mass spectral data. Some of these compounds were found to have significant activity

scholarly journals Synthesis and Anti-inflammatory Activity of 2-Methoxy-4-(1-phenyl-3- methyl-1H-pyrazol-5-yl)phenol) and Its Aminomethyl Derivatives

2020 ◽  
Vol 32 (3) ◽  
pp. 607-611
Author(s):  
H. Hayun ◽  
R.N. Fauzan ◽  
N.T. Wibowo ◽  
A. Asrianingtiyas ◽  
N. Afriliana ◽  
...  
Keyword(s):  
Spectral Data ◽  
Protein Denaturation ◽  
Diclofenac Sodium ◽  
Parent Compound ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Structure Activity ◽  
Pka Value ◽  
Aminomethyl Derivatives ◽  
Anti Inflammatory

Using heat-induced protein denaturation technique, a series of novel synthesized 1,5-diarylpyrazole compounds, namely 2-methoxy-4-(1-phenyl-3-methyl-1H-pyrazol-5-yl)phenol (1) and its aminomethyl derivatives (2a-e) were evaluated for their anti-inflammatory potentiality. The structures of the synthesized compounds were elucidated using FTIR, NMR (1H & 13C) and mass spectral data. The study found that the activity of aminomethyl derivatives (2a-e) was higher than that of parent compound 1. In this series, aminomethyl derivatives bearing dimethylamino-methyl, diethylaminomethyl and pyrrolidinomethyl moieties (2a, 2c and 2e, respectively) were more active than diclofenac sodium, which was used as a standard. A study on the structure-activity relationship (SAR) suggested that the activity of aminomethyl moiety of the compound was influenced by its pKa value. Thus, novel compounds act as potential anti-inflammatory agents.

scholarly journals Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Chatrasal Singh Rajput ◽  
Shiwani Singhal
Keyword(s):  
Spectral Data ◽  
Elemental Analysis ◽  
Inflammatory Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Analgesic Activities

A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3″-chloro-2″-oxo-4″-substitutedphenylazetidin-1″-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2″-substitutedphenyl-4″-oxo-1″,3″-thiazolidin-3″-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic activities.

Synthesis and Some Reactions of Naphthoylacetanilides

1978 ◽  
Vol 33 (4) ◽  
pp. 425-428 ◽  
Author(s):  
M. I. Ali ◽  
M. M. S. El-Morsy ◽  
N. M. Hassan ◽  
M. Sharaf
Keyword(s):  
Spectral Data ◽  
Aromatic Aldehyde ◽  
Glutaric Acid ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Aryldiazonium Salt

AbstractThe structure of some naphthoylacetanilides (1) obtained from a new route of synthesis is elucidated via inspection of IR, NMR, and mass spectral data. Napthoylacetanilides condensed with one or two moles of aromatic aldehyde to give 2-(naphthoyl)-cinnamanili-des (2) or 3-aryl-2,2′-dinaphthoyl-glutaric acid dianilides (3). Compound 2b added phenylmercaptan to give 3-phenyl 3-phenylthio-2-naphthoyl-propananilide (4). Reduction of 2b gave 2-benzyl 2-(2-naphthoyl)acetanilide (5). 1 is coupled with aryldiazonium salt to give 2-oxo naphthoylacetanilides-2-arylhydrazones (6). The mechanism of the reactions is discussed.

scholarly journals Synthesis and Anti-inflammatory Activity of Some Novel Pyrazole Derivatives of Gallic Acid

2009 ◽  
Vol 6 (s1) ◽  
pp. S123-S128 ◽  
Author(s):  
S. Arunkumar ◽  
K. Ilango ◽  
R. S. Manikandan ◽  
N. Ramalakshmi
Keyword(s):  
Sodium Hydroxide Solution ◽  
Aromatic Aldehydes ◽  
Inflammatory Activity ◽  
Pyrazole Derivatives ◽  
Paw Edema ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Derivatives Of

In the present study, a new series of [5-substituted-3-(phenylamino)-1H-pyrazol-1yl] (3,4,5-trihydroxyphenyl)-methanone (4a-j) have been synthesized. 3, 4, 5-Trihydroxy benzohydrazide (1) was synthesized from propyl gallate and hydrazine hydrate in presence of ethanol. Chalcones (2a-j) were synthesized from acetanilide and various aromatic aldehydes in presence of ethanol and sodium hydroxide solution. By refluxing the compound (1) and compounds (2a-j) in presence of ethanol yielded [5-substituted-3-(phenylamino)-4.5-dihydropyrazol-1yl] (3,4,5-trihydroxy phenyl)-methanone (3a-j). The final compounds [5-substituted-3-(phenylamino)-1H-pyrazol-1yl] (3,4,5-trihydroxyphenyl)-methanone (4a-j) were synthesized by treating compounds (3a-j) with bromine water. The synthesized compounds have been characterized by IR,1HNMR and Mass spectral data. The compounds were evaluated forin vivoanti-inflammatory activity by carrageenan induced paw edema test. In general all compounds were found to exhibit good anti-inflammatory activity.

scholarly journals Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin- 3-yl)prop-2-en-1-ones and Their Antimicrobial Activity

2019 ◽  
Vol 31 (9) ◽  
pp. 1895-1898
Author(s):  
Relangi Siva Subrahmanyam ◽  
Venkateswara Rao Anna
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
In Vitro Antimicrobial Activity ◽  
Mass Spectral ◽  
Fungal Organisms

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.

Sign in / Sign up

Export Citation Format

Share Document