scholarly journals Role of Surgical Intervention in Hereditary Spherocytosis with Haemolytic Anaemia, Splenomegaly and Jaundice

2021 ◽  
pp. 222-226
Author(s):  
K. Senthil Kumar ◽  
K. Abinaya ◽  
R. Anantharamakrishnan ◽  
K. Pranay
Keyword(s):  
Haemolytic Anaemia ◽  
Surgical Intervention ◽  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
Parvovirus B19 Infection ◽  
Current Infection ◽  
One Year

haemolytic anaemia, splenomegaly and jaundice, admitted in Chettinad hospital and research institute during one year period from  January 2019 to January 2020. Surgical intervention is indicated for selected patients with hereditary spherocytosis with haemolytic anaemia and jaundice to abate the hemolytic process after correction of anaemia with blood transfusion. Pigmented gallstones are seen in more than 50% cases for which incidence increases with severity of hemolysis and with age. Complications include aplastic anemia (most common after parvovirus B19 infection), haemolytic crisis during inter-current infection, megaloblastic crisis – during folic acid deficiency, cardiomyopathy, hematological malignancies.

Occurrence and Clinical Role of Active Parvovirus B19 Infection in Transplant Recipients

1999 ◽  
Vol 18 (11) ◽  
pp. 811-813 ◽  
Author(s):  
G. Gallinella ◽  
E. Manaresi ◽  
S. Venturoli ◽  
G. L. Grazi ◽  
M. Musiani ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Transplant Recipients ◽  
Clinical Role ◽  
Parvovirus B19 Infection

scholarly journals Acute parvovirus B19 infection in identical twins unmasking previously unidentified hereditary spherocytosis

2014 ◽  
Vol 2014 (jul29 1) ◽  
pp. bcr2013202957-bcr2013202957 ◽  
Author(s):  
D. G. Forde ◽  
A. Cope ◽  
B. Stone
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Identical Twins ◽  
Parvovirus B19 Infection

scholarly journals Clinical Case of Aplastic Crisis Associated with Extramedullary Hematopoiesis in an Adult With Hereditary Spherocytosis and Parvovirus B19 Infection

2015 ◽  
Vol 34 (1-2) ◽  
pp. 39-44
Author(s):  
Andreea Jercan ◽  
Rusu Munteanu Gina ◽  
Camelia Dobrea ◽  
Daniel Coriu ◽  
Aurelia Tatic
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Extramedullary Hematopoiesis ◽  
Blood Film ◽  
Red Cell Membrane ◽  
Infectious Episode ◽  
Indirect Bilirubin ◽  
Aplastic Crisis ◽  
Chronic Hemolysis ◽  
Parvovirus B19 Infection

Abstract Hereditary spherocytosis is an inherited hemolytic anemia due to red cell membrane defects, characterised by chronic hemolysis with different severity degrees, splenomegaly and microspherocytosis on the peripheral blood film. Among the possible complications in these patients are aplastic crisis and extramedullary hematopoiesis. In this article we present the case of a 42 years old man with hereditary spherocytosis diagnosed during childhood (average haemoglobin (Hb) value of 11-12 g/dl), which presented with worsening anemia, fever, chills, bone and muscle pain. The evolution was with accentuation of anemia (Hb 4.2 g/dl), decease of reticulocyte number (Ret 0,8%) and bilirubin (indirect bilirubin 2.7 g/dl). ParvovirusB19 DNA was 100.000.000 copies/ml. A computer tomography (CT)scan was performed and showed extramedullary hematopoiesis areas situated paravertebraly in the inferior thorax and hepatosplenomegaly. The infectious episode was self-limited and improved with substitution treatment.

Folates: Modern Pregnant Health Support

2020 ◽  
pp. 37-42
Author(s):  
M.V. Khaitovich ◽  
Keyword(s):  
Folic Acid ◽  
Physiological Role ◽  
Chemical Compounds ◽  
The Body ◽  
Folic Acid Deficiency ◽  
Vitamin B9 ◽  
Acid Deficiency ◽  
Health Support ◽  
Spinach Leaves

Folates (folic acid-based chemical compounds) got their name from the Latin “folio” - “leaf”, since they were first synthesized from spinach leaves, in which vitamin B9 is found in maximum quantities. As an important cofactor in carbon metabolism, folates are involved in the most important metabolic processes in the body, in particular, they play a key role in the synthesis of nucleotides and DNA replication. The article provides information on the physiological role of folates, their metabolism and its genetic aspects. The clinical significance of folate deficiency is examined, their sources and doses are described, and the interaction of folic acid and drugs is highlighted. Keywords: folate, metabolism, folic acid deficiency, pregnancy.

scholarly journals Folic Acid Deficiency in Haemolytic Anaemia

1963 ◽  
Vol 39 (457) ◽  
pp. 661-662 ◽  
Author(s):  
J. Forshaw ◽  
L. Harwood
Keyword(s):  
Folic Acid ◽  
Haemolytic Anaemia ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

Gestational folic acid-deficiency alters embryonic eye development: possible role of basement membrane proteins in eye malformations

Nutrition ◽  
2021 ◽  
pp. 111250
Author(s):  
Ouafa Sijilmassi ◽  
Aurora Del Río Sevilla ◽  
Estela Maldonado Bautista ◽  
María del Carmen Barrio Asensio
Keyword(s):  
Folic Acid ◽  
Membrane Proteins ◽  
Basement Membrane ◽  
Eye Development ◽  
Folic Acid Deficiency ◽  
Basement Membrane Proteins ◽  
Acid Deficiency

scholarly journals Comprehensive surveillance data suggest a prominent role of parvovirus B19 infection in Belarus and the presence of a third subtype within subgenotype 1a

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marina A. Yermalovich ◽  
Alina M. Dronina ◽  
Galina V. Semeiko ◽  
Elena O. Samoilovich ◽  
Vladislav V. Khrustalev ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Parvovirus B19 ◽  
Phylogenetic Analyses ◽  
Erythema Infectiosum ◽  
High Incidence ◽  
Molecular Investigation ◽  
Common Clinical Presentation ◽  
Parvovirus B19 Infection ◽  
Comprehensive Surveillance

AbstractHuman parvovirus B19 (B19V) infection is not notifiable in Belarus and its most common clinical presentation erythema infectiosum (EI) is often difficult to distinguish from other exanthematous diseases. The objective of this study was to provide comprehensive data about EI epidemiology in Belarus based on the serological and molecular investigation of samples from measles and rubella discarded cases collected between 2005 and 2019. Overall, 4919 sera were investigated for IgM antibodies against B19V and the positive cases were analysed according to year, season and age. B19V DNA was amplified by PCR in a total of 238 sera from all over the country, and sequenced for phylogenetic analyses. B19V infection was confirmed in 1377 (27.8%) measles and rubella discarded cases. Two high incidence periods and a seasonal increase of EI between mid-February to mid-July were identified. Children from 4 to 6 and from 7 to 10 years of age represented the largest groups of patients (22.51% and 22.66% of all cases, respectively), followed by adults between 20 and 29 years of age (14.23%). Among the 238 B19Vs sequenced, one belonged to subgenotype 3b and 237 to subgenotype 1a with 81 (34.2%) clustering with subtypes 1a1 and 153 (64.6%) with 1a2. Three strains (1.2%) formed an additional, well-supported cluster suggesting the presence of another subtype of 1a, tentatively named 1a3. The epidemiological and molecular analyses highlighted not only the prominent role of B19V in exanthematous diseases in Belarus, but also suggested a previously underestimated diversity of subgenotype 1a sequences with a third subtype 1a3.

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