scholarly journals Case Report on Guillain-Barre Syndrome (GBS) in Adult

2021 ◽  
pp. 432-436
Author(s):  
Pranay Bende ◽  
Seema Singh
Keyword(s):  
Normal Sinus Rhythm ◽  
Supportive Therapy ◽  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Upper Body ◽  
Clinical State ◽  
Intermittent Fever ◽  
Acinetobacter Species ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Introduction: Guillain-Barre-syndrome is when the immune system attacks the peripheral nervous system were disease progresses to trembling and muscle weakness in both hands and legs, which progress to upper body and arms. Clinical Findings: High grade intermittent fever, low back pain, B/L LL weak, urinary incontinence which is intermittent in nature. Diagnostic Evaluation: Neurological examination- revealed B/L UL and LL weakness, acute onset of quadriparesis. X-Ray – revealed normal sinus rhythm.  CSF examination – revealed No RBC; No pus cell; No Organism seen. Lab investigation – Hb% 10%, total RBC count 4.45, total WBC 10400, total platelet 2.33, SGOT 226 SGPT 83, Peripheral Smear RBCs - Normocytic Normochromic platelets adequate smear no Haemoparasite seen. Blood Culture: revealed Growth of Acinetobacter species. Therapeutic Intervention: Inj. Optineurone 1gm, Inj.Pantop 40mg, Tab.PCM,Inj. Tramadol 500mg, Immunoglobin (Ig) 100ml , physiotherapy and supportive therapy. Outcome: The symptoms and clinical state of the patient improved over time. The patient's weakness began to improve after 5 days of IV-Ig therapy. Conclusion: The patient was hospitalised to the neurosurgery ICU AVBRH on 05/06/20 with the known case of guillain-barre syndrome-(GBS). After receiving therapy, she showed significant progress.

scholarly journals Electrophysiological patterns in patient with Guillain-Barre syndrome

2021 ◽  
Vol 12 (1) ◽  
pp. 16-21
Author(s):  
SM Monowar Hossain ◽  
Zahed Ali ◽  
Mohammad Motiur Rahman ◽  
Md Aolad Hossain ◽  
Pallab Kanti Saha ◽  
...  
Keyword(s):  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Axonal Neuropathy ◽  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Acute Motor Axonal Neuropathy ◽  
Cross Sectional ◽  
Female Ratio ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Background: Guillain-Barre syndrome (GBS) is an acute, frequently severe and fulminant polyradiculoneuropathy that is autoimmune in nature. Incidence and predominant subtypes of GBS differ geographically. Electrophysiology has important role in subtyping GBS. This study aimed to evaluate the electrophysiological findings in patient of GBS. Methods: This was a hospital based cross-sectional descriptive study and conducted at the Department of Neurology in Sir Salimullah Medical College & Mitford Hospital, Dhaka and National Institute of Neurosciences and Hospital, Dhaka during July 2017 to June 2018. Clinically diagnosed 53 patients with GBS were enrolled according to prefixed selection criteria. Detail history taking, clinical examination, nerve conduction study and cerebrospinal fluid (CSF) examination was performed in all cases. Clinical findings, nerve conduction study (NCS) parameters, CSF findings and demographic profiles were evaluated. Results: Mean ± SD age of presentation was 41.64 (±14.56) years and median age was 42.0 years. There were total 33(62 %) males and 20 (38 %) females with male: female ratio of 1.7:1. Clinically two-thirds(62.3%) of patients had both upper and lower limb involvement (62.3%), facial weakness was in 32.1% and 13.2% had bulbar involvement. Acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor sensory axonal neuropathy (AMSAN)were found to be 51%, 32% and 17% respectively. CSFprotein was elevated in most of the patients with a range of 16-725 mg/dl. Highest CSF protein was found in AIDP. Conclusion: Electrophysiological studies play an important role in the early detection; characterization of GBS.In this study, the commonest type of GBS was AIDP. Higher levels of CSF protein, absent H-reflex and Fresponse, sural sparing and unexcitable nerves are more frequently present in AIDP. BIRDEM Med J 2022; 12(1): 16-21

scholarly journals Acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome) following dengue fever

2011 ◽  
Vol 53 (4) ◽  
pp. 223-225 ◽  
Author(s):  
Eduardo Gonçalves
Keyword(s):  
Female Child ◽  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Clinical Image ◽  
Biochemical Tests ◽  
Peripheral Facial Palsy ◽  
Guillain Barré Syndrome ◽  
Electrophysiological Findings ◽  
Laboratory Examinations ◽  
Guillain Barré

This paper reports a case of dengue in a six-year-old female child who suddenly developed excruciating headaches, fever, myalgia and paresis. Laboratory examinations included blood count, platelet count, biochemical tests (BUN, creatinine, aminotransferases, and total bilirubin and bilirubin fractions) and specific IgM titers (enzyme-immunoassay with recombinant tetravalent dengue). After ten days of hospitalization and having already been in a home environment, a new clinical image emerged, characterized by dysphagia, dysphonia, weakness, peripheral facial palsy and paresthesia. The diagnosis of Guillain-Barré Syndrome was based on clinical findings, cerebrospinal fluid examination, electrophysiological findings and the exclusion of other pathologies. Our case, as some shown in previous reports, calls attention to the possibility that Guillain-Barré Syndrome may occur in association with dengue.

scholarly journals Hyperreflexia ? an Uncommon Presentation of Guillain-Barré Syndrome

2017 ◽  
Vol 7 (2) ◽  
pp. 111-112
Author(s):  
NS Neki ◽  
Gagandeep Singh Shergill ◽  
Amanpreet Kaur
Keyword(s):  
Cerebrospinal Fluid ◽  
Nerve Conduction Study ◽  
Clinical Findings ◽  
Acute Onset ◽  
Guillain Barre Syndrome ◽  
Motor Weakness ◽  
Uncommon Presentation ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
European Populations

Guillain-Barré syndrome (GBS) is an acquired acute autoimmune polyradiculoneuropathy. Progressive motor weakness and areflexia are essential for diagnosis. But in some cases hyperreflexia can be seen. Diagnosis of GBS was made based on history and clinical findings and was supported by cerebrospinal fluid (CSF) studies and nerve conduction study (NCS). We hereby report a case of a 42-year-old male presenting with acute onset flaccid quadriparesis. There was frank hyperreflexia in all four limbs. Although reflex preservation and hyperreflexia can be noted in axonal variant of GBS in Chinese, Japanese, and European populations, it is uncommon in India.J Enam Med Col 2017; 7(2): 111-112

Atypical Clinical Presentations of Pediatric Acute Immune-Mediated Polyneuropathy

2019 ◽  
Vol 34 (5) ◽  
pp. 268-276 ◽  
Author(s):  
Naama Yosha-Orpaz ◽  
Sharon Aharoni ◽  
Malcolm Rabie ◽  
Yoram Nevo
Keyword(s):  
Axonal Neuropathy ◽  
Significant Proportion ◽  
Respiratory Muscles ◽  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Acute Motor Axonal Neuropathy ◽  
Presenting Symptoms ◽  
Tertiary Center ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in children. During the acute phase, the disorder can be life-threatening by involving the respiratory muscles and the autonomic nervous system. Nevertheless, the prognosis is good, and most children achieve full recovery. The aim of this study was to characterize the clinical and electrophysiologic findings in children with Guillain-Barré syndrome referred to a tertiary center in Israel. A retrospective database review from 2009 to 2015 identified 39 children. Data on clinical presentation, respiratory complications, and long-term neurologic outcomes were collected. Atypical clinical findings at admission included asymmetric weakness in 23%, nonascending weakness in 30%, and normal deep tendon reflexes in 28%. Eight children were later diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Electrophysiologic findings, available in 12 patients with Guillain-Barré syndrome, revealed acute inflammatory demyelinating polyradiculoneuropathy (AIDP) in 4 (33.5%), AIDP with secondary axonal changes in 3 (25%), and acute motor axonal neuropathy (AMAN) subtype in 4 (33.5%); 8% had no abnormal findings. On follow-up, 71% of the children with Guillain-Barré syndrome fully recovered compared to 14% of the children with CIDP. Corresponding rates of neurologic sequelae were 29% and 86%. Clinicians should be alert to the atypical presenting symptoms of Guillain-Barré syndrome, which occur in a significant proportion of children.

Case 23

2018 ◽  
Author(s):  
Bashar Katirji
Keyword(s):  
Axonal Neuropathy ◽  
Recovery Phase ◽  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Acute Motor Axonal Neuropathy ◽  
Fisher Syndrome ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Diagnostic Sensitivity And Specificity ◽  
Guillain Barré

Guillain-Barré syndrome is the prototype of acute immune-mediated neuropathies. Guillain-Barré syndrome has several subtypes including acute inflammatory demyelinating polyneuropathy, acute motor axonal neuropathy, and acute motor sensory axonal neuropathy. Guillain-Barré syndrome has also several variants including Miller Fisher syndrome, ataxic form, and pharyngeal–cervical–brachial form. This case highlights the clinical findings in Guillain-Barré syndrome and discusses in details the diagnostic criteria that are essential in confirming the diagnosis and excluding mimickers of the disorder. This is followed by a detailed discussion on the electrodiagnostic findings in Guillain-Barré syndrome during the acute presentation and recovery phase. The diagnostic sensitivity and specificity of the various findings seen on nerve conduction studies are included.

scholarly journals EVALUATING THE EFFECTIVENESS OF A TWO YEAR REHABILITATION OF A PATIENT WITH GUILLAIN-BARRE SYNDROME: A CASE REPORT

2021 ◽  
Vol 31 (5) ◽  
pp. 100-103
Author(s):  
Agnė Timlerytė ◽  
Lolita Grygalytė ◽  
Aleksandra Kubiliūtė ◽  
Raimondas Savickas
Keyword(s):  
Case Report ◽  
Functional Independence Measure ◽  
Functional Independence ◽  
Guillain Barre Syndrome ◽  
Upper Body ◽  
Outpatient Rehabilitation ◽  
Guillain Barré Syndrome ◽  
Tingling Sensation ◽  
Guillain Barré

Aim: To present a clinical case of multiple multidiscipli­nary rehabilitation courses after a total of three episodes of Guillain-Barre syndrome (GBS). Case report: A 72-year-old female was hospitalized to Lithuanian University of Health Sciences (LUHS) Hos­pital Kaunas Clinics Neurology department, complaining of lower back pain spreading to the lateral surfaces of both legs and a cold, tingling sensation in her feet that has been continuing for two months. Subacute demyelinating polyneuropathy was diagnosed. The patient suffered a total of three episodes of GBS and underwent a course of multidisciplinary rehabilitation after each of them. Despite the worsening condition during every episode of GBS, improvements were observed in the Barthel index, Functional Independence Measure, Lovett scores and dynamometry after each course of rehabilitation. Phy­siotherapy, occupational therapy, massage, transcutaneus electrical nerve stimulation, physical therapy, speech the­rapy, psychologist consultation and social worker consul­tation were applied. After the last course of rehabilitation, our patient was autonomous within the range of a ward, able to eat served food, put clothes on the upper body with minimal help, on the lower body – with moderate help. Moderate help was needed for all other activities. Conclusions: After undergoing multidisciplinary in and outpatient rehabilitation, the condition of our patient im­proved. This case highlights the importance of both early inpatient and continuous long-term rehabilitation for the achievement of the maximum functional recovery.

Correlation of nerve ultrasound, electrophysiological, and clinical findings in post Guillain-Barré syndrome

2013 ◽  
Vol 18 (3) ◽  
pp. 232-240 ◽  
Author(s):  
Antonios Kerasnoudis ◽  
Kalliopi Pitarokoili ◽  
Volker Behrendt ◽  
Ralf Gold ◽  
Min-Suk Yoon
Keyword(s):  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Nerve Ultrasound ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Intravenous immunoglobulin in COVID-19 associated Guillain–Barré syndrome in pregnancy

2021 ◽  
Vol 14 (5) ◽  
pp. e242365
Author(s):  
Jao Jarro Garcia ◽  
Christian Wilson Turalde ◽  
Marjorie Anne Bagnas ◽  
Veeda Michelle Anlacan
Keyword(s):  
Intravenous Immunoglobulin ◽  
Supportive Therapy ◽  
Pregnant Patient ◽  
Present Knowledge ◽  
Guillain Barre Syndrome ◽  
Upper Respiratory Tract ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Upper Respiratory ◽  
Guillain Barré

The COVID-19 pandemic has led to a rise in cases of Guillain-Barré syndrome (GBS). This autoimmune sequela is a manifestation of the neurotropism potential of the virus. At present, knowledge regarding the pathophysiology, clinical features, management and outcomes of the condition is still evolving. This paper presents the case of a 22-year-old pregnant patient who came in with a history of upper respiratory tract symptoms followed by acroparaesthesia and progressive ascending weakness. She was confirmed to have COVID-19 and GBS and was subsequently managed with intravenous immunoglobulin (IVIg) followed by supportive therapy. To the authors’ knowledge and based on their literature search, this is the first reported case of GBS in a COVID-19 confirmed pregnant patient who received IVIg.

scholarly journals Guillain–Barré Syndrome Likely due to Relapsing Hepatitis A

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Edgar Blecker ◽  
Maryam Ehtsham
Keyword(s):  
Hepatitis A ◽  
Acute Infection ◽  
Elevated Serum ◽  
Clinical Findings ◽  
Guillain Barre Syndrome ◽  
Motor Weakness ◽  
Progressive Muscle Weakness ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barré syndrome (GBS) is an immune-mediated disease of the peripheral nervous system that can be caused by various bacterial and virologic agents. The disease is characterized by progressive muscle weakness and paralysis. Rarely, GBS is preceded by an acute infection with hepatitis A. Here, we present the case of a 53-year-old woman who presented with progressively worsening motor weakness in the distal extremities. She reported a preceding gastrointestinal infection with nausea, vomiting, and diarrhea two weeks prior to her presentation to the emergency department. She was noted to have elevated serum transaminase levels and hepatitis A IgM and IgG antibodies signifying likely relapsing hepatitis A. She was later diagnosed with GBS on the basis of clinical findings and albuminocytologic dissociation in the cerebrospinal fluid. She was treated with intravenous immunoglobulin with subsequent improvement in her strength.

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