Bullous Disease of Diabetes (Bullosis Diabeticorum)

2021 ◽  
pp. 552-557
Author(s):  
Mohammed Salah Hussein ◽  
Shatha Saeed Mohammed Alqahtani ◽  
Amani Hussain Almutawa ◽  
Batool Mesfer Alqahtany ◽  
M. Albulushi Amer Ismail ◽  
...  
Keyword(s):  
Acanthosis Nigricans ◽  
Histological Study ◽  
Direct Immunofluorescence ◽  
Inflammatory Condition ◽  
Necrobiosis Lipoidica ◽  
Bullous Disease ◽  
Long Time ◽  
Strong Consensus ◽  
Bullosis Diabeticorum ◽  
Rule Out

Acanthosis nigricans, acrochordrons, diabetic dermatopathy, necrobiosis lipoidica, and bullous diabeticorum are some of the cutaneous symptoms of diabetes. Bullous illness (bullosis diabeticorum) is a blistering, non-inflammatory condition of the acral skin. Diabetes bullous illness is more common in people who have had diabetes for a long time or who have many comorbidities. Although the actual cause is uncertain, it is likely to be multifactorial. Neuropathy, nephropathy, vasculopathy, and UV (ultraviolet) light are all suggested to have a role. BD is most likely caused by the various problems that come with poorly managed diabetes. The exact number of people who have BD is unknown. The majority of case studies in the literature were based on a small number of cases. Bullous diabeticorum is a restrictive diagnosis, which necessitates a histological study that includes direct immunofluorescence to rule out other vesicobullous illnesses. In terms of BD management, no strong consensus has formed. The blisters have historically been thought to be self-limiting, with bullae resolving in 2 to 6 weeks if left untreated. In some cases antibiotic may be used. In this article we’ll be looking at Bullosis Diabeticorum. Its etiology, epidemiology, diagnosis, and treatment.

scholarly journals A Study on the Potential Role of Occlusal Fissure Fractures in the Etiopathogenesis of Equine Cheek Teeth Apical Infections

2019 ◽  
Vol 36 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Katherina Y. Wellman ◽  
Padraic M. Dixon
Keyword(s):  
Computed Tomography ◽  
Methylene Blue ◽  
Potential Role ◽  
Histological Study ◽  
Extraction Process ◽  
Dental Tissue ◽  
Rule Out

Thirty-nine equine cheek teeth diagnosed as having anachoretic apical infections and also having occlusal fissure fractures, but without occlusal pulpar exposure, that had been orally extracted without causing occlusal damage and 10 control teeth were used in this study. The teeth were individually imaged by computed tomography, occlusally stained with methylene blue and visually reexamined, then sectioned subocclusally at 5 mm intervals until the fissure fractures could no longer be detected. A limited histological study was then performed on 7 apically infected and 5 control teeth. Standard computed tomography only detected 1 of 39 fissure fractures. Thirteen of the 39 stained teeth had subocclusal fissure fractures visually identified at approximately 6 mm beneath the surface, and in 9 of these 13 teeth the fissure fractures had deeper staining to a level immediately above or into a pulp horn, indicating a potential route for bacterial pulpitis. However, the current study cannot rule out the possibility that the extraction process, long-term formalin storage, or the processing of teeth may have allowed for deeper staining. Additionally, methylene blue may penetrate dental tissue more readily than bacteria can invade. Further studies on the potential role of fissure fractures in the etiopathogenesis of cheek teeth apical infection are warranted.

ANTI-EPILEPTIC DRUGS AND BRAIN AND BEHAVIOURAL DEVELOPMENT IN ANIMAL MODELS AND HUMANS

2010 ◽  
Vol 21 (4) ◽  
pp. 283-306
Author(s):  
NAGHME ADAB ◽  
MICHAEL F O'DONOGHUE
Keyword(s):  
Animal Models ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Developmental Problems ◽  
Gestational Exposure ◽  
Behavioural Effects ◽  
Confounding Variables ◽  
Long Time ◽  
Behavioural Repertoire ◽  
Rule Out

Women with epilepsy constitute about 0.6% of pregnancies. The potential for major structural malformations following gestational exposure to anti-epileptic drugs (AEDs) is well known and causes concern as how best to manage epilepsy during pregnancy. In this review we focus on the structural and functional effects on the developing brain to complement other recent reviews. We do not cover neural tube defects which have been reviewed elsewhere. Suffice to say that carbamazepine, lamotrigine and, in particular, valproate exposure are associated with them. We discuss studies based on animal models as well as those that have followed-up children exposed to AEDs in-utero. Careful longitudinal human research can document the cognitive and behavioural effects, but the long time scales required and inability to rule out confounding variables, both genetic and environmental, are serious limitations. Animal studies are based on the assumption that many developmental processes are conserved between the animals used in the models (most often rodents) and humans. However, the hugely expanded cortex and cognitive and behavioural repertoire of humans implies that there are aspects that can not be well modelled. In addition, due to differences in how susceptible different species are to various teratogens, studies always need to be done in man as well. Nevertheless, an understanding of the molecular mechanisms of neuro-teratogenesis derived from animal models will help us predict which anti-epileptic drugs are likely to cause fewer neuro-developmental problems in humans.

scholarly journals Retroperitoneal Schwannoma in the Renal Hilum: A Case Report

2015 ◽  
Vol 8 (3) ◽  
pp. 394-398
Author(s):  
Yohei Kumano ◽  
Takashi Kawahara ◽  
Sawako Chiba ◽  
Yoko Maeda ◽  
Mari Ohtaka ◽  
...  
Keyword(s):  
Case Report ◽  
Contrast Enhancement ◽  
Rare Case ◽  
Histological Study ◽  
Retroperitoneal Tumor ◽  
Tumor Mass ◽  
Renal Hilum ◽  
Retroperitoneal Schwannoma ◽  
Contrast Ct ◽  
Rule Out

A 73-year-old male was referred to our department for further treatment of a right retroperitoneal tumor. Contrast CT showed a tumor mass measuring 33 × 26 mm in size with poor contrast enhancement. Because we were unable to rule out tumor malignancy, we planned an operation. The tumor was easily separated and removed without nephrectomy. Histological study revealed a schwannoma. It is rare for this kind of tumor to arise from the retroperitoneum (approximately 0.7% of all cases), in particular at the renal hilum. We herein report a rare case of retroperitoneal schwannoma arising from the renal hilum.

scholarly journals Petrology of potassic alkaline ultramafic and carbonatitic rocks from Planalto da Serra (Mato Grosso State), Brazil

2014 ◽  
Vol 6 (4) ◽  
Author(s):  
Piero Comin-Chiaramonti ◽  
Celso Gomes ◽  
Angelo Min ◽  
Excelso Ruberti ◽  
Vicente Girardi ◽  
...  
Keyword(s):  
Mantle Source ◽  
Crustal Contamination ◽  
Alkaline Magmatism ◽  
Mato Grosso ◽  
Rock Types ◽  
Long Time ◽  
Late Neoproterozoic ◽  
Rock Association ◽  
Rule Out ◽  
Metasomatized Mantle

AbstractThe Planalto da Serra igneous rocks form plugs, necks and dykes of carbonate-rich ultramafic lamprophyres (aillikites and glimmerites with kamafugitic affinity) and carbonatites (alvikites and beforsites). Phlogopite and/or tetraphlogopite, diopside and melanitic garnet are restricted to aillikitic rock-types, whereas pyroclore occurs only in carbonatites. Aillikites and carbonatites are altered to hydrotermalites, having chlorite and serpentine as dominant minerals. Planalto da Serra igneous rock association has kamafugitic affinity (i.e. effusive, ultrapotassic. High LREE/HREE fractionation, incompatible elements data and Sr-Nd isotopes, suggest that the K-ultramafic alkaline and carbonatite rocks originated from a variably metasomatized mantle source enriched in radiogenic Sr. Crustal contamination is negligible or absent. Age values of 600 Ma rule out the geochronological relationship between the investigated intrusions and the Mesozoic alkaline bodies from the Azimuth 125° lineament. The TDM model ages allow to conclude that Planalto da Serra magma is derived from the partial melting of a mantle source metasomatised by K-rich carbonatated melt during the Early to Late Neoproterozoic. On the basis of alkaline magmatism repetitions at 600 Ma and 90–80 Ma we question the subsistence of a stationary mantle plume for so long time.

scholarly journals Case for diagnosis

2013 ◽  
Vol 88 (4) ◽  
pp. 652-654 ◽  
Author(s):  
Amanda Nascimento Cavalleiro de Macedo Mota ◽  
Natalia Solon Nery ◽  
Carlos Baptista Barcaui
Keyword(s):  
Diabetes Mellitus ◽  
Conservative Management ◽  
Laboratory Tests ◽  
Secondary Infection ◽  
Normal Skin ◽  
Rare Disorder ◽  
Diabetic Patients ◽  
Bullous Disease ◽  
Bullosis Diabeticorum

We present a case of bullosis diabeticorum. It is a rare disorder, probably underdiagnosed, associated with long-term diabetes mellitus. Its etiology remains unclear. It is characterized by tense blisters, with serous content, recurrent and spontaneous on normal skin especially in the acral regions. Displays self-limiting course. No specific laboratory tests for diagnosis of this bullous disease exist. Clinical and conservative management to prevent secondary infection reduces morbidity in diabetic patients.

scholarly journals PEMBUATAN SURAT KUASA MEMBEBANKAN HAK TANGGUNGAN TANPA DIIKUTI AKTA PEMBERIAN HAK TANGGUNGAN

2019 ◽  
Vol 3 (1) ◽  
pp. 29
Author(s):  
Sri Endah Cahayani
Keyword(s):  
Power Of Attorney ◽  
Proof Of Ownership ◽  
Long Time ◽  
Rule Out

Jaminan yang diberikan oleh debitor kepada bank masih relatif cukup banyak dengan bukti kepemilikan yang masih berupa letter C, sehingga dalam pengikatan jaminannya dengan menggunakan Surat Kuasa Membebankan Hak Tanggungan (SKMHT) dengan jangka waktu 3 (tiga) bulan, dengan demikian memerlukan perpanjangan beberapa kali untuk dapat dilakukan pemasangan Hak Tanggungan, karena untuk proses pengurusan letter C menjadi sertifikat dibutuhkan waktu relatif cukup panjang kurang lebih 12 (duabelas) bulan, hal ini tidak menutup kemungkinan tidak dapat terlaksananya penandatanganan perpanjangan Surat Kuasa Membebankan Hak Tanggungan (SKMHT).Kata kunci: jaminan, akta, hak tanggungan, surat kuasaThe guarantee given by the debtor to the bank is still relatively large with proof of ownership that is still in the form of letter C, so that in binding the guarantee by using a Power of Attorney Charges (SKMHT) with a period of 3 (three) months, thus requiring several extensions to mortgage rights can be done, because for the process of arranging the letter C into a certificate, it takes relatively long time of approximately 12 (twelve) months, this does not rule out the possibility of signing the extension of the Power of Attorney Charges (SKMHT).Keywords: guarantee, deed, mortgage rights, power of attorney

scholarly journals IgA Pemphigus in a Child – a Case Report

2017 ◽  
Vol 9 (1) ◽  
pp. 14-21
Author(s):  
Branislav Lekić ◽  
Mirjana Gajić-Veljić ◽  
Svetlana Popadić ◽  
Miloš Nikolić
Keyword(s):  
Case Report ◽  
Complete Remission ◽  
Direct Immunofluorescence ◽  
Cell Surfaces ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Iga Pemphigus ◽  
Subcorneal Pustular Dermatosis ◽  
Keratinocyte Cell ◽  
The Face

Abstract IgA pemphigus (IGAP) is a rare autoimmune bullous disease characterized by IgA deposits on keratinocyte cell surfaces. The IGAP is classified into: 1) subcorneal pustular dermatosis (SPD) type, and 2) intraepidermal neutrophilic (IEN) IgA dermatosis type. So far, only 9 children with IGAP have been described in the literature, of whom only 3 with SPD type. We report a 3-year-old boy with SPD type of IGAP. Clinically, he presented with pruritic vesicles, pustules and erosions on the face, trunk, groin area, and extremities. Histopathology showed subcorneal pustules containing a few acantholytic cells. Direct immunofluorescence (DIF) test of Tzanck smear showed intercellular IgA deposits on the surface of the groups of epidermal cells. Oral dapsone and prednisone induced remission after two weeks; the treatment was discontinued 11 months later, and complete remission was achieved during 19 months without any treatment. Direct immunofluorescence of Tzanck smear is a simple, sensitive, rapid and non-aggressive test, very suitable for the diagnosis of IGAP in children.

scholarly journals BONE MARROW IN FOLLICULAR LYMPHOMA PROGNOSIS

2016 ◽  
Vol 15 (3) ◽  
pp. 99-102 ◽  
Author(s):  
N. N. Tupitsyn ◽  
N. A. Falaleeva ◽  
A. V. Mozhenkova ◽  
A. I. Pavlovskaya
Keyword(s):  
Bone Marrow ◽  
Overall Survival ◽  
Follicular Lymphoma ◽  
Histological Study ◽  
Bone Marrow Involvement ◽  
International Prognostic Index ◽  
Prognostic Significance ◽  
Prognostic Index ◽  
Prognostic Role ◽  
Long Time

Background. Bone marrow is the mostfrequent metastatic site in follicular lymphoma, 40-70 % cases. It’s unfovourable prognostic role is stated in the index FLIPI-2 (Follicular Lymphoma International Prognostic Index-2). Objective. To study both prognostic role of bone marrow involvement and it’s relation to erythropoiesis peculiarities in follicular lymphoma was the purpose of this research. Materials and methods. Histological study was performed in 269 follicular lymphoma patients. Erythropoiesis peculiarities were studied in that patients according to standard myelogram analysis. Results. Bone marrow involvement was noted according to trephine biopsy section staining in 37,9 % of follicular lymphoma case (102 from 269). Bone marrow involvement did not influenced the prognosis (overall survival) in all period of observation (p = 0,18). Longterm survival (more than 48 months) was negatively influenced by bone marrow involvement (p = 0,04). Intertrabecular pattern of follicular lymphoma growth in bone marrow was negative prognostic factor (p = 0,02). We noted negative correlation between bone marrow involvement and the elevation of orthochromic normoblasts in bone marrow of patients with follicular lymphoma. In cause of bone marrow such elevation was noted in 67 %, and in the absense of involvement - in 78 % (p = 0,043). Elevation of orthochromic normoblasts did not influenced the overall survival of follicular lymphoma patients (p = 0,89). Conclusion. Bone marrow involvement in follicular lymphoma plays prognostically unfavourable role in long-time observation periods (later than 48 months). The most unfavourable are the intertrabecular patchy lesions. Involvement of bone marrow is in opposite relations to elevation of orthochromic normoblast, but the latter sign is of no prognostic significance.

scholarly journals Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Hassan Riad ◽  
Hamda Al Ansari ◽  
Khaled Mansour ◽  
Haya Al Mannai ◽  
Hussein Al Sada ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Hypochromic Anemia ◽  
Immunoperoxidase Staining ◽  
Direct Immunofluorescence ◽  
Pathological Features ◽  
Anterior Aspect ◽  
Normal Ranges ◽  
Perivascular Infiltrate ◽  
Clinical And Pathological Features ◽  
Bullosis Diabeticorum

A 50-year-old diabetic female presented with highly pruritic vesicles and excoriated lesions over the anterior aspect of both lower legs. The lesions were recurrent over the last two years. She received a lot of medications with partial response. Hb A1c was 10.8% (normal up to 7%). CBC showed microcytic, hypochromic anemia. Serum zinc, folate, IgE, TSH and T4 were all within normal ranges. Biopsy showed epidermal separation secondary to keratinocyte necrosis and minimal monocytic, perivascular infiltrate. Direct immunofluorescence was negative for intraepidermal and subepidremal deposition of immunoglobulin. The dermis was positive for mucin deposition stainable by both PAS and Alcian blue while it was negative for Congo red and APC immunoperoxidase staining for amyloid material. In conclusion, the case was diagnosed as bullosis diabeticorum by distinctive clinical and pathological features and after exclusion of other possible differentials. Pruritus was partially controlled by topical potent steroid and the case was resolved spontaneously after eight months.

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