Temporary Unilateral Hearing Loss Impairs Spatial Auditory Information Processing in Neurons in the Central Auditory System

Temporary conductive hearing loss (CHL) can lead to hearing impairments that persist beyond resolution of the CHL. In particular, unilateral CHL leads to deficits in auditory skills that rely on binaural input (e.g., spatial hearing). Here, we asked whether single neurons in the auditory midbrain, which integrate acoustic inputs from the two ears, are altered by a temporary CHL. We introduced 6 weeks of unilateral CHL to young adult chinchillas via foam earplug. Following CHL removal and restoration of peripheral input, single-unit recordings from inferior colliculus (ICC) neurons revealed the CHL decreased the efficacy of inhibitory input to the ICC contralateral to the earplug and increased inhibitory input ipsilateral to the earplug, effectively creating a higher proportion of monaural responsive neurons than binaural. Moreover, this resulted in a ∼10 dB shift in the coding of a binaural sound location cue (interaural-level difference, ILD) in ICC neurons relative to controls. The direction of the shift was consistent with a compensation of the altered ILDs due to the CHL. ICC neuron responses carried ∼37% less information about ILDs after CHL than control neurons. Cochlear peripheral-evoked responses confirmed that the CHL did not induce damage to the auditory periphery. We find that a temporary CHL altered auditory midbrain neurons by shifting binaural responses to ILD acoustic cues, suggesting a compensatory form of plasticity occurring by at least the level of the auditory midbrain, the ICC.

Upper hemisphere sound image control with horizontal-arranged loudspeakers based on parametric head-related transfer functions

The 22.2 multichannel sound system has been developed for an ultra high-definition television system. This system consists of twenty two loudspeakers and two sub-woofers called low frequency effects, and can reproduce three-dimensional sound image appropriate to the ultra high-definition television system. However, this system has a problem of high cost to install. On the other hand, the multichannel sound system with horizontal-arranged loudspeakers has lower cost to install than full scale one. However, this system cannot reproduce an upper sound image. Therefore, in this paper, we propose the upper sound image control with horizontal-arranged loudspeakers based on the parametric head-related transfer functions. The proposed method generates binaural signals to control the sound image elevationally based on the parametric head-related transfer functions in the median plane. Also, the proposed system uses the interaural level difference to control the sound image of binaural signals azimuthally. Finally, the proposed method generates output signals for horizontal-arranged loudspeakers from binaural signals by designing a multichannel inverse system based on multi-input / output inverse theorem. The experimental results show that the proposed method can control the sound image to elevation angle with the same accuracy as binaural lreproduction. The 22.2 multichannel sound system has been developed for an ultra high-definition television system. This system consists of twenty loudspeakers and two sub-woofers called low frequency effects, and can reproduce three-dimensional sound image appropriate to the ultra high-definition television system. However, this system has a problem of high cost to install. On the other hand, the multichannel sound system with horizontal-arranged loudspeakers has lower cost to install than full scale one. However, this system cannot reproduce an upper sound image. Therefore, in this paper, we propose the upper sound image control with horizontal-arranged loudspeakers based on the parametric head-related transfer functions. The proposed method generates binaural signals to control the sound image elevationally based on the parametric head-related transfer functions in the median plane. Also, the proposed system uses the interaural level difference to control the sound image of binaural signals azimuthally. Finally, the proposed method generates output signals for horizontal-arranged loudspeakers from binaural signals by designing a multichannel inverse system based on multi-input / output inverse theorem. The experimental results show that the proposed method can control the sound image to elevation angle with the same accuracy as binaural reproduction.

Do Auditory Mismatch Responses Differ Between Acoustic Features?

Mismatch negativity (MMN) is the electroencephalographic (EEG) waveform obtained by subtracting event-related potential (ERP) responses evoked by unexpected deviant stimuli from responses evoked by expected standard stimuli. While the MMN is thought to reflect an unexpected change in an ongoing, predictable stimulus, it is unknown whether MMN responses evoked by changes in different stimulus features have different magnitudes, latencies, and topographies. The present study aimed to investigate whether MMN responses differ depending on whether sudden stimulus change occur in pitch, duration, location or vowel identity, respectively. To calculate ERPs to standard and deviant stimuli, EEG signals were recorded in normal-hearing participants (N = 20; 13 males, 7 females) who listened to roving oddball sequences of artificial syllables. In the roving paradigm, any given stimulus is repeated several times to form a standard, and then suddenly replaced with a deviant stimulus which differs from the standard. Here, deviants differed from preceding standards along one of four features (pitch, duration, vowel or interaural level difference). The feature levels were individually chosen to match behavioral discrimination performance. We identified neural activity evoked by unexpected violations along all four acoustic dimensions. Evoked responses to deviant stimuli increased in amplitude relative to the responses to standard stimuli. A univariate (channel-by-channel) analysis yielded no significant differences between MMN responses following violations of different features. However, in a multivariate analysis (pooling information from multiple EEG channels), acoustic features could be decoded from the topography of mismatch responses, although at later latencies than those typical for MMN. These results support the notion that deviant feature detection may be subserved by a different process than general mismatch detection.

Synchronized Automatic Gain Control in Bilateral Cochlear Implant Recipients Yields Significant Benefit in Static and Dynamic Listening Conditions

Individuals with bilateral cochlear implants (BiCIs) rely mostly on interaural level difference (ILD) cues to localize stationary sounds in the horizontal plane. Independent automatic gain control (AGC) in each device can distort this cue, resulting in poorer localization of stationary sound sources. However, little is known about how BiCI listeners perceive sound in motion. In this study, 12 BiCI listeners’ spatial hearing abilities were assessed for both static and dynamic listening conditions when the sound processors were synchronized by applying the same compression gain to both devices as a means to better preserve the original ILD cues. Stimuli consisted of band-pass filtered (100–8000 Hz) Gaussian noise presented at various locations or panned over an array of loudspeakers. In the static listening condition, the distance between two sequentially presented stimuli was adaptively varied to arrive at the minimum audible angle, the smallest spatial separation at which the listener can correctly determine whether the second sound was to the left or right of the first. In the dynamic listening condition, participants identified if a single stimulus moved to the left or to the right. Velocity was held constant and the distance the stimulus traveled was adjusted using an adaptive procedure to determine the minimum audible movement angle. Median minimum audible angle decreased from 17.1° to 15.3° with the AGC synchronized. Median minimum audible movement angle decreased from 100° to 25.5°. These findings were statistically significant and support the hypothesis that synchronizing the AGC better preserves ILD cues and results in improved spatial hearing abilities. However, restoration of the ILD cue alone was not enough to bridge the large performance gap between BiCI listeners and normal-hearing listeners on these static and dynamic spatial hearing measures.

Speech in noise perception improved by training fine auditory discrimination: far and applicable transfer of perceptual learning

A longstanding focus of perceptual learning research is learning specificity, the difficulty for learning to transfer to tasks and situations beyond the training setting. Previous studies have focused on promoting transfer across stimuli, such as from one sound frequency to another. Here we examined whether learning could transfer across tasks, particularly from fine discrimination of sound features to speech perception in noise, one of the most frequently encountered perceptual challenges in real life. Separate groups of normal-hearing listeners were trained on auditory interaural level difference (ILD) discrimination, interaural time difference (ITD) discrimination, and fundamental frequency (F0) discrimination with non-speech stimuli delivered through headphones. While ITD training led to no improvement, both ILD and F0 training produced learning as well as transfer to speech-in-noise perception when noise differed from speech in the trained feature. These training benefits did not require similarity of task or stimuli between training and application settings, construing far and wide transfer. Thus, notwithstanding task specificity among basic perceptual skills such as discrimination of different sound features, auditory learning appears readily transferable between these skills and their “upstream” tasks utilizing them, providing an effective approach to improving performance in challenging situations or challenged populations.

Do auditory mismatch responses differ between acoustic features?

Mismatch negativity (MMN) is the electroencephalographic (EEG) waveform obtained by subtracting event-related potential (ERP) responses evoked by unexpected deviant stimuli from responses evoked by expected standard stimuli. While the MMN is thought to reflect an unexpected change in an ongoing, predictable stimulus, it is unknown whether MMN responses evoked by changes in different stimulus features have different magnitudes, latencies, and topographies. The present study aimed to investigate whether MMN responses differ depending on whether sudden stimulus change occur in pitch, duration, location or vowel identity respectively.To calculate ERPs to standard and deviant stimuli, EEG signals were recorded in normal-hearing participants (N=20; 13 males, 7 females) who listened to roving oddball sequences of artificial syllables. In the roving paradigm, any given stimulus is repeated several times to form a standard, and then suddenly replaced with a deviant stimulus which differs from the standard. Here, deviants differed from preceding standards along one of four features (pitch, duration, vowel or interaural level difference). The feature levels were individually chosen to match behavioral discrimination performance.We identified neural activity evoked by unexpected violations along all four acoustic dimensions. Evoked responses to deviant stimuli increased in amplitude relative to the responses to standard stimuli. A univariate (channel-by-channel) analysis yielded no significant differences between MMN responses following violations of different features. However, in a multivariate analysis (pooling information from multiple EEG channels), acoustic features could be decoded from the topography of mismatch responses, although at later latencies than those typical for MMN. These results support the notion that deviant feature detection may be subserved by a different process than general mismatch detection.