Medical geography and health geography have made significant contributions to studies of human health by addressing the spatial patterns of disease exposure, location of health care services, and place-specific processes producing health and wellbeing. Human geography and human-environment geography have also contributed with emerging attention to the body, uncertainty, and health and environment interactions. What remains understudied are the co-occurrence of multiple disease patterns, including the relationships between infectious disease and addiction. We review geographic research on infectious disease and addiction to advance a theoretical framework that emphasizes the centrality of complexity, uncertainty, difference, and care in shaping human health.