Glucose-6-phosphate dehydrogenase gene Ala365Thr mutation in an Iraqi family with confusing clinical differences

Objectives Glucose-6-phosphate dehydrogenase (G6PD) has role in the Embden Meyerhof road. Any loss of its function causes NADPH to cease, leaving erythrocytes susceptible to oxidative damage resulting in acute hemolytic anemia attacks secondary to drugs or infection and favism. Because of X-linked recessive inheritance males are mainly affected. Being heterozygous, females have less severe clinical presentation. Case presentation G6PD deficiency was suspected in a six-year-old girl from an Iraqi family with a history of yellowing of skin and darkening of urine after eating broad beans. Besides the patient, G6PD levels were found low in the father and in two sisters who showed no symptoms. The father was found hemizygous and the three sisters were found heterozygous for NM_000402.4c.1093G>A(p.A365T)(6.Ala365Thr) mutation while the mother was normal. Conclusions G6PD enzyme deficiency can be seen in both genders, and it may be presented with different clinical manifestations even within the people having the same mutation.

GASTRONOMICAL CODE AS ELEMENT OF EVERYDAY LIFE POETICS IN DRAMA TEXTS (ANTON CHEKHOV’S THREE SISTERS AND BETH HENLEY’S CRIMES OF THE HEART)

The paper sets out to explore the functions of food discourse in the plays Three Sisters by Anton Chekhovand Crimes of the Heart by Beth Henley. Based on the critically established continuity between the two plays, the paperlooks at the ways the dramatists capitalize on food imagery to achieve their artistic goals. It seemed logical to discuss thealimentary practices within the framework of everyday life studies, moved to the forefront of literary scholarship by theanthropological turn in the humanities. Enhanced by semiotic approach, this perspective enables one to understand foodproducts and consumption manners as performing a variety of functions in each play. Most obviously, they are instrumentalin creating the illusion of «everydayness» vital for new drama. Then, for Chekhov, food comes to epitomize thespiritless materiality of contemporary life, while in Henley’s play it is predominantly used, in accordance with the play’sfeminist agenda, as a grotesque substitute for the lack of human affection. Relying upon the fundamental cultural distinctionbetween everyday and non-everyday makes it possible to compare representations of festive occasions in the twoplays seen through the gastronomical lens of «eating together». Despite substantial differences, the emphases on alimentarypractices in the plays serve to realize the inexhaustible dramatic potential inherent in the minutiae of quotidian life.

Sound Patterns as Connectors: An Experimental Production of Three Sisters

The actor is tasked with embodying text in order to portray the characters’ intentions. This article shows that such a complex task escalates when the actor performs in a second language. In South Africa, where eleven official languages are embraced, the multiplicity and crossover of spoken languages is a daily challenge for actors and theatre makers, leading to a preference for physical performances, which limits the use of text. The production of embodied sound patterns embedded in a text informed the creative process of an experimental production of Chekhov’s Three Sisters. It was created with a second-language cast (speakers of Setswana and Afrikaans) whose over-arching goal was to consider the embodied patterns of pre-linguistic expression as a theatre-making tool. When reflecting on their work, the actors indicated that their explorations facilitated a connection with the text in English and generated the relevant dynamics for the play’s sociopolitical themes to be adequately ‘translated’ to a contemporary multilingual South African context. Karina Lemmer is a Senior Lecturer in the Department of Performing Arts at Tshwane University of Technology in Gauteng, where she teaches acting and voice. She has directed a number of multilingual productions, including Buried Voices (2018) and Motlotlegi (2019), and has published in the Voice and Speech Review (2018).

Spaces of Labour: Three Sisters, ’Til Madness Do Us Part, Bitter Money

Wang’s focus on workers constitutes a unique entry point for studying labour conditions throughout China’s economic development. This chapter offers an in-depth discussion of Wang’s filmmaking in relation to spaces of labour and labour issues. Through the close analyses of Three Sisters, ’Til Madness Do Us Part, and Bitter Money, the discussion expands on the topic of labour which Wang first explored with Tiexi qu: West of the Tracks. These works also re-connect to the flow of laid-off and migrant workers of the Tiexi industrial district and evoke the overarching power of the economy in defining people’s lives and destinies. This chapter also offers a comparative reading of Wang’s Three Sisters and John Ford’s The Grapes of Wrath (1940).

Familial Frontal Fibrosing Alopecia

Frontal fibrosing alopecia (FFA) is an emerging disease in Western countries. We present the cases of three sisters who were referred simultaneously to the Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, in 2018. All patients suffered from at least partial frontotemporal hairline recession and eyebrow loss. Following trichoscopic examination, the three sisters were diagnosed with FFA. Only one of the sisters agreed to be treated; she was prescribed with topical clobetasol propionate solution and minoxidil and achieved disease control at the three-month follow-up. These patients represent a new case of familial FFA wherein three sisters as well as their mother were affected by FFA. A systematic review found a total of 24 cases of familial FFA, of which this report is the 25th. In the majority of families, only females were affected (88%) while in the remainder both males and females (8%) were affected; there was only one family where only males were affected (4%). The relationship between the affected individuals was predominately between sisters (56%) followed by mother and daughter (32%). The median age was 61 years old (range: 14–88 years) and the duration of the disease ranged between 3–360 months. Family groups of FFA are an infrequently described phenomenon with unknown prevalence. Keywords: Alopecia; Dermatology; Hair Diseases; Case Report; Spain.

Imperial Women on Coins and in Roman Cult

After an opening focus on Caligula’s three sisters Drusilla, Agrippina the Younger, and Julia Livilla, the first living women figured and identified on centrally struck coins, the chapter addresses coins as evidence for imperial women, and the connections of imperial women to Rome’s public religion and religious culture. Women themselves determined neither their numismatic depictions, nor the choice of deity or abstraction for the reverse of a portrait coin. Further examination delves into imperial women and imperial cult, as priestesses and as recipients of cult; women in oaths and vows; and reports linking them with Judaism and Christianity. Religion is the arena in which imperial women receive the most visibility and honor, but even here they had little agency and were sidelined.