773. Hypochlorous Acid Generating Electrochemical Catheter Prototype for Prevention of Intraluminal Infections

Background Central-line associated bloodstream infection (CLABSI) contributes to mortality and cost. While aseptic dressings and antibiotic-impregnated catheters can prevent extraluminal infections, intraluminal infections remain a source of CLABSIs with limited prevention options. Methods In this proof-of-concept study, an electrochemical intravascular catheter (e-catheter) prototype capable of electrochemically generating hypochlorous acid intraluminally on the surface of platinum electrodes polarized at a constant potential of 1.5 VAg/AgCl was developed. After 24h of pre-polarization at 1.5 VAg/AgCl, their activity was tested by inoculating four clinical isolates derived from catheter-related infections, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecium and Escherichia coli. Figure 1. In vitro catheter and e-catheter models. Results E-catheters generated a mean HOCl concentration of 15.86±4.03 μM and had a mean pH of 6.14±0.79. e-catheters prevented infections with all four species, with an average reduction of 8.41±0.61 log10 CFU/mL at 48h compared to controls. Figure 3. Measurement of pH and HOCl at 48 hours in polarized e-catheters. Each dot represents a replicate; bars represent means. Figure 4. Prevention of infection after 48 hours of polarization (24 hours of infections) using e-catheters (polarized and non-polarized) compared to blank catheters. * indicates statistically significant reduction of cell counts in polarized e-catheter compared to blank catheter (p <0.05). Conclusion Polarized e-catheters which generate low amounts of HOCl continuously should be further developed to prevent intraluminal infection. Disclosures Haluk Beyenal, Ph.D, patent (Other Financial or Material Support, HB holds a patent: Beyenal H CD, Fransson BA, Sultana ST. . 2018. Electrochemical reduction or prevention of infections. U.S. patent 20180207301A1, international patent WO/2017/011635.) Robin Patel, MD, 1928 Diagnostics (Consultant)BioFire Diagnostics (Grant/Research Support)ContraFect Corporation (Grant/Research Support)Curetis (Consultant)Hylomorph AG (Grant/Research Support)IDSA (Other Financial or Material Support, Editor's Stipend)Infectious Diseases Board Review Course (Other Financial or Material Support, Honoraria)Mammoth Biosciences (Consultant)NBME (Other Financial or Material Support, Honoraria)Netflix (Consultant)Next Gen Diagnostics (Consultant)PathoQuest (Consultant)PhAST (Consultant)Qvella (Consultant)Samsung (Other Financial or Material Support, Patent Royalties)Selux Diagnostics (Consultant)Shionogi & Co., Ltd. (Grant/Research Support)Specific Technologies (Consultant)TenNor Therapeutics Limited (Grant/Research Support)Torus Biosystems (Consultant)Up-to-Date (Other Financial or Material Support, Honoraria) Robin Patel, MD, BioFire (Individual(s) Involved: Self): Grant/Research Support; Contrafect (Individual(s) Involved: Self): Grant/Research Support; IDSA (Individual(s) Involved: Self): Editor's stipend; NBME, Up-to-Date and the Infectious Diseases Board Review Course (Individual(s) Involved: Self): Honoraria; Netflix (Individual(s) Involved: Self): Consultant; TenNor Therapeutics Limited (Individual(s) Involved: Self): Grant/Research Support; to Curetis, Specific Technologies, Next Gen Diagnostics, PathoQuest, Selux Diagnostics, 1928 Diagnostics, PhAST, Torus Biosystems, Mammoth Biosciences and Qvella (Individual(s) Involved: Self): Consultant

Survey on Sedation Training for Pediatric Residents in Training Hospitals

The purpose of this study was to investigate current status of sedation training for the residents in pediatric dentistry training institutions and opinions about continuing education after the residency program. Surveys were sent to 18 pediatric dentistry training institutions by e-mail, and the responses were collected and analyzed. Most of the sedation education period for the residents were the 1st-year education (61.1%) and 1 - 3 years of integrated education (55.6%). In terms of an externship, 5 institutions (27.8%) sent their residents to the department of anesthesiology. Second half of the 1st year (50%) was the highest for a resident to use sedation for the first time. The period of supervisor participation varied from not participating at all to whole time throughout the residency program. The sedation training is conducted at all training institutions, but there were variations in the experience that a resident can gain. All training institutions agreed on the necessity of continuing education of the sedation, but there were various opinions regarding time, method, and the period of review course. Overall, this study suggested that continuing education should be consisted of 1 - 2 hours of didactic education every year and clinical skills and simulation training in every 2 - 3 years.

Exploring Anatomy Background, Perceived Anatomy Preparedness, and Academic Performance Among OT Graduate Students: A Survey Study

Date Presented 04/12/21 The purpose of this study was to explore students’ prior anatomy coursework, their perceived preparedness in anatomy, and their performance in a mandatory human movement course in an OT program. The secondary purpose was to determine student interest in a potential online anatomy review course. More than half the participants felt that they were underprepared for anatomy-related content, indicating that an additional stand-alone anatomy course may be beneficial to students in OT programs. Primary Author and Speaker: Ashleigh Giles Additional Authors and Speakers: Cristin Holland, Susan Agostine Contributing Authors: Stephanie Bristol, John Sideris, Emily Schulze, Yun-Ju Chen, Elizabeth Choi, Aaron Dallman, Linda Watson, Elizabeth Crais, Grace Baranek, and Amanda M. Wiles

Successful Implementation of a National Ethiopian Ophthalmology Review Course

Background: Development of a national ophthalmology review course for the education of residents and use of a standardized international exam as a metric of resident knowledge and education.Methods: A 3 day review course for all Ethiopian ophthalmology residents, taught by visiting and local faculty, in preparation for the International Council of Ophthalmology (ICO) exam. The ICO exam serves as an external and standardizing measurement of residency curriculum and preparedness for clinical practice. The course and exam was provided free of cost to residents. Baseline knowledge was assessed with the ICO exam in 2017 and results compared with performance each year after the introduction of the review course. Results: Over 2 years of implementation, the resident passage rates of the basic sciences and optics and refraction exams increased by 10% and 28% and a 15% improvement in passage rate of the clinical sciences exam. These scores were significantly higher than international averages. Additionally, increasing numbers of residents were able to sit for the advanced exam with a passage rate of 67% in 2019 compared to the international passage rate of 56%.Conclusions: The implementation of a national review course is feasible and effective in enhacing the education of ophthalmology residents in Ethiopia. The review course and ICO exam serves as a key metric in the education of Ethiopian residents and their knowledge as it compares to their peers in other countries.