Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Matrine-family alkaloids as tetracycloquinolizindine analogues from Traditional Chinese Medicine Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L possess various pharmacological activities and have aroused great interests over the past decades. Especially, a lot of matrine derivatives have been designed and synthesized and their biological activities investigated, and encouraging results have continuously been achieved in recent several years. These studies are helpful to develop more potent candidates or therapeutic agents and disclose their molecular targets and mechanisms. This paper reviews recent advances in the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification.

Convenient synthesis of carbon nanodots for detecting Cr(vi) and ascorbic acid by fluorimetry

Carbon nanodots (CDs) were simply synthesized from Sophora flavescens Ait. “On–off–on” fluorescent probes for the sensitive and selective detections of Cr(iv) and ascorbic acid (AA) were founded and well applied in real samples.