TiAl alloy was successfully brazed with Ag-CuO filler in air atmosphere under simple technical conditions. The wettability of a series of Ag-CuO fillers on TiAl was analyzed. Ag-2mol%CuO filler possessed good wetting behavior on TiAl alloy. The microstructure and mechanical properties of the brazed joints were investigated. Oxide layers can be found on both sides, which can be divided into external TiO2-rich layer and internal Al2O3-rich layer. The maximum shear strength of the joint was obtained at 1020 °C holding for 20 min.