Reactive group effects on the photophysical and biological properties of 2-phenyl-1H-phenanthro[9,10-d]imidazole derivatives as fluorescent markers

The presence of a pyridyl disulfide group limits the use of phenanthroimidazole derivatives in medical imaging, while the introduction of an N-hydroxysuccinimide ester along with changes to the PhI backbone may be used to create valuable fluorescent probes for applications in biomedical imaging.

An alkylating immobilization linker for immunochemical epigenetic assessment

A bifunctional linker molecule containing nitrogen mustard and a cyclic disulfide group has been developed for the covalent immobilization of intact DNA, which allows quantitative analysis of epigenomic modification in immobilized DNA using SPR-based immune sensing.