Sequence Set Design for a New LFM-PC Hybrid Modulated Radar Signal

In this paper we study the code design problem of a new form of linear frequency modulation phase-coded (LFM-PC) hybrid signal with wide Doppler tolerance based on a range-Doppler discrete ambiguity function (DAF) to get better detection performance and anti-jamming capability. The DAF of the LFM-PC inter pulse signal is derived within the Doppler tolerance. Two optimization models are established. One is single pulse sequence design (SSD) for Doppler tolerance extension based on minimum integral normalized sidelobe level (INSL); the other is multi pulse sequence set design (MSSD) for signal orthogonality based on the minimizing sum of the normalized DAF sidelobe (NDAFSL) and discrete cross ambiguity function (DCAF). Two low-complexity signal optimization methods based on alternating direction method of multiplier (ADMM) are proposed, respectively. The simulation results show that the optimized signals have either wide Doppler tolerance or good orthogonal performance, and the optimization methods (i.e., SSD-ADMM and MSSD-ADMM) have the characteristics of fast convergence speed and low operation amount.

Current Practice and New Developments in the Use of In Vivo Magnetic Resonance Spectroscopy for the Assessment of Key Metabolites Implicated in the Pathophysiology of Schizophrenia

Magnetic Resonance Spectroscopy (MRS) has become a valuable tool for investigating the biochemical bases of both normal processes in the healthy brain and elucidating the pathophysiology of neuropsychiatric disorders. As a rapidly advancing field, new developments in pulse sequence design have seen new possibilities arise in terms of what can be done with in vivo spectroscopy. While the applications of MRS are numerous, this review has been confined to the use of single voxel spectroscopy in the assessment of five key metabolites and their roles in schizophrenia: N-acetylaspartate (NAA), glutamate (Glu) and glutamine (Gln), γ-aminobutyric acid (GABA) and glutathione (GSH). This article will briefly cover the roles they play in schizophrenia, review current methods being used in their assessment and highlight new approaches that may potentially overcome some of the limitations current methods pose.