Prediction of lncRNA-disease association based on a Laplace normalized random walk with restart algorithm on heterogeneous networks

Background More and more evidence showed that long non-coding RNAs (lncRNAs) play important roles in the development and progression of human sophisticated diseases. Therefore, predicting human lncRNA-disease associations is a challenging and urgently task in bioinformatics to research of human sophisticated diseases. Results In the work, a global network-based computational framework called as LRWRHLDA were proposed which is a universal network-based method. Firstly, four isomorphic networks include lncRNA similarity network, disease similarity network, gene similarity network and miRNA similarity network were constructed. And then, six heterogeneous networks include known lncRNA-disease, lncRNA-gene, lncRNA-miRNA, disease-gene, disease-miRNA, and gene-miRNA associations network were applied to design a multi-layer network. Finally, the Laplace normalized random walk with restart algorithm in this global network is suggested to predict the relationship between lncRNAs and diseases. Conclusions The ten-fold cross validation is used to evaluate the performance of LRWRHLDA. As a result, LRWRHLDA achieves an AUC of 0.98402, which is higher than other compared methods. Furthermore, LRWRHLDA can predict isolated disease-related lnRNA (isolated lnRNA related disease). The results for colorectal cancer, lung adenocarcinoma, stomach cancer and breast cancer have been verified by other researches. The case studies indicated that our method is effective.

Imaginaire identitaire/identité imaginaire dans Meursault, contre-enquête de Kamel Daoud: question(s) de démêlés…

" Identity is approached from the perspective of the genre of literary counter- investigation, in the wake of Laurent Demanze’s study Un nouvel âge de l’enquête. In post-colonial Algeria, the motif of spectrality is bound up with an imaginary of grief and impossible mourning, typified by Kamel Daoud’s Meursault, contre-enquête. In this context, identity is synonymous with alienation. Like his predecessors Camus and Assia Djebar, Daoud is conducting his own quest for freedom, promoting the relational and ethical value of the imaginary as a universal network of images that counter the narrow enclosure of nationalist and fundamentalist discourse in a fundamentally dynamic encounter with the world and the other."

Global Position Prediction for Interactive Motion Capture

We present a method for reconstructing the global position of motion capture where position sensing is poor or unavailable. Capture systems, such as IMU suits, can provide excellent pose and orientation data of a capture subject, but otherwise need post processing to estimate global position. We propose a solution that trains a neural network to predict, in real-time, the height and body displacement given a short window of pose and orientation data. Our training dataset contains pre-recorded data with global positions from many different capture subjects, performing a wide variety of activities in order to broadly train a network to estimate on like and unseen activities. We compare training on two network architectures, a universal network (u-net) and a traditional convolutional neural network (CNN) - observing better error properties for the u-net in our results. We also evaluate our method for different classes of motion. We observe high quality results for motion examples with good representation in specialized datasets, while general performance appears better in a more broadly sampled dataset when input motions are far from training examples.

Multi-attribute Recognition,the key to Universal Neural Network

<p>To achieve the recognition of multi-attribute of object, I redesign the mnist dataset, change the color, size, location of the number. Meanwhile, I change the label accordingly. The deep neural network I use is the most common convolution neural network. Through test,we can conclude that we can use one neural network to recognize multi-attribute so long as the attribute difference of objects can be represented by functions. The concrete network(generation network) can generate the output which the input rarely contained from the attributes the network learned. Its generalization ability is good because the network is a continuous function. Through one more test, We can conclude that one neural network can do image recognition, speech recognition,and nature language processing and other things so long as the output node and the input node and more parameters add into the network. The network is universal so long as the network can process different inputs. I guess that the phenomenon of synaesthesia is the result of multi-input and multi-output. I guess that connection in mind can realize through the universal network and sending the output into input.<b></b></p>

Multi-attribute Recognition,the key to Universal Neural Network

<p>To achieve the recognition of multi-attribute of object, I redesign the mnist dataset, change the color, size, location of the number. Meanwhile, I change the label accordingly. The deep neural network I use is the most common convolution neural network. Through test,we can conclude that we can use one neural network to recognize multi-attribute so long as the attribute difference of objects can be represented by functions. The concrete network(generation network) can generate the output which the input rarely contained from the attributes the network learned. Its generalization ability is good because the network is a continuous function. Through one more test, We can conclude that one neural network can do image recognition, speech recognition,and nature language processing and other things so long as the output node and the input node and more parameters add into the network. The network is universal so long as the network can process different inputs. I guess that the phenomenon of synaesthesia is the result of multi-input and multi-output. I guess that connection in mind can realize through the universal network and sending the output into input.<b></b></p>

Multi-attribute Recognition,The key to Universal Neural Network

<p><b>To achieve the recognition of multi-attribute of object, I redesign the mnist dataset, change the color, size, location of the number. Meanwhile, I change the label accordingly.</b><b> </b><b>The deep neural network I use is the most common convolution neural network. Through test,we can conclude that we can use one neural network to recognize multi-attribute so long as the attribute difference of objects can be represented by functions. The </b><b>c</b><b>oncrete network(generation network) can generate the output which the input rarely contained from the attributes the network learned. Its generalization ability is good because the network is a continuous function. Through one more test, We can conclude that one neural network can do image recognition, speech recognition,and nature language processing and other things so long as the output node and the input node and more parameters add into the network. The network is universal so long as the network can process different inputs.</b><b> I guess that t</b><b>he phenomenon of synaesthesia is the result of multi-input and multi-output. </b><b>I guess that c</b><b>onnection in mind can realize through the universal network and sending the output into input.</b><b></b></p>

Bottom-up and Top-down: Bidirectional Additive Net for Edge Detection

Image edge detection is considered as a cornerstone task in computer vision. Due to the nature of hierarchical representations learned in CNN, it is intuitive to design side networks utilizing the richer convolutional features to improve the edge detection. However, there is no consensus way to integrate the hierarchical information. In this paper, we propose an effective and end-to-end framework, named Bidirectional Additive Net (BAN), for image edge detection. In the proposed framework, we focus on two main problems: 1) how to design a universal network for incorporating hierarchical information sufficiently; and 2) how to achieve effective information flow between different stages and gradually improve the edge map stage by stage. To tackle these problems, we design a consecutive bottom-up and top-down architecture, where a bottom-up branch can gradually remove detailed or sharp boundaries to enable accurate edge detection and a top-down branch offers a chance of error-correcting by revisiting the low-level features that contain rich textual and spatial information. And attended additive module (AAM) is designed to cumulatively refine edges by selecting pivotal features in each stage. Experimental results show that our proposed methods can improve the edge detection performance to new records and achieve state-of-the-art results on two public benchmarks: BSDS500 and NYUDv2.