heterogeneous networks
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2022 ◽  
Vol 2022 ◽  
pp. 1-10
Airong Yang ◽  
Guoxin Yu

With the advent of the Internet Web 2.0 era, storage devices used to store website data are developing at an ever-increasing high-growth rate and a diversified trend. The focus on the structured data storage model has reduced the responsiveness of traditional relational databases to data changes. NoSQL database is scalable, has a powerful and flexible data model and a large amount of data, and has an increasing application potential in the memory field. Heterogeneous networks are composed of third-party computers, network equipment, and systems. Network types are usually used for other protocols to support other functions and applications. The research on heterogeneous networks can be traced back to the BARWAN project that started in 1995 at the University of California, Berkeley. The project leader RHKatz merged multiple types of nested networks for the first time to form heterogeneous network requirements for various future terminal services. Construction engineering refers to an engineering entity formed by installing pipelines and equipment that support the construction of various houses and ancillary facilities. “House construction” refers to projects with roofs, beams, columns, walls, and foundations that can form internal spaces to meet people’s needs in production, living, learning, and public activities. Among them, the engineering evaluation index is a statistical index used to evaluate and compare the quality and effects of social and economic activities through the use of equipment, such as capital turnover rate and employee labor efficiency. It is the exchange of corporate performance evaluation content and the expression of corporate performance evaluation content.

2022 ◽  
Vol 23 (S1) ◽  
Fei Song ◽  
Shiyin Tan ◽  
Zengfa Dou ◽  
Xiaogang Liu ◽  
Xiaoke Ma

Abstract Background Drug combination, offering an insight into the increased therapeutic efficacy and reduced toxicity, plays an essential role in the therapy of many complex diseases. Although significant efforts have been devoted to the identification of drugs, the identification of drug combination is still a challenge. The current algorithms assume that the independence of feature selection and drug prediction procedures, which may result in an undesirable performance. Results To address this issue, we develop a novel Semi-supervised Heterogeneous Network Embedding algorithm (called SeHNE) to predict the combination patterns of drugs by exploiting the graph embedding. Specifically, the ATC similarity of drugs, drug–target, and protein–protein interaction networks are integrated to construct the heterogeneous networks. Then, SeHNE jointly learns drug features by exploiting the topological structure of heterogeneous networks and predicting drug combination. One distinct advantage of SeHNE is that features of drugs are extracted under the guidance of classification, which improves the quality of features, thereby enhancing the performance of prediction of drugs. Experimental results demonstrate that the proposed algorithm is more accurate than state-of-the-art methods on various data, implying that the joint learning is promising for the identification of drug combination. Conclusions The proposed model and algorithm provide an effective strategy for the prediction of combinatorial patterns of drugs, implying that the graph-based drug prediction is promising for the discovery of drugs.

2022 ◽  
Vol 23 (1) ◽  
Liugen Wang ◽  
Min Shang ◽  
Qi Dai ◽  
Ping-an He

Abstract Background More and more evidence showed that long non-coding RNAs (lncRNAs) play important roles in the development and progression of human sophisticated diseases. Therefore, predicting human lncRNA-disease associations is a challenging and urgently task in bioinformatics to research of human sophisticated diseases. Results In the work, a global network-based computational framework called as LRWRHLDA were proposed which is a universal network-based method. Firstly, four isomorphic networks include lncRNA similarity network, disease similarity network, gene similarity network and miRNA similarity network were constructed. And then, six heterogeneous networks include known lncRNA-disease, lncRNA-gene, lncRNA-miRNA, disease-gene, disease-miRNA, and gene-miRNA associations network were applied to design a multi-layer network. Finally, the Laplace normalized random walk with restart algorithm in this global network is suggested to predict the relationship between lncRNAs and diseases. Conclusions The ten-fold cross validation is used to evaluate the performance of LRWRHLDA. As a result, LRWRHLDA achieves an AUC of 0.98402, which is higher than other compared methods. Furthermore, LRWRHLDA can predict isolated disease-related lnRNA (isolated lnRNA related disease). The results for colorectal cancer, lung adenocarcinoma, stomach cancer and breast cancer have been verified by other researches. The case studies indicated that our method is effective.

Electronics ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 146
Issa Elfergani ◽  
Abubakar Sadiq Hussaini ◽  
Jonathan Rodriguez ◽  
Raed A. Abd-Alhameed

Fifth-generation will support significantly faster mobile broadband speeds, low latency, and reliable communications, as well as enabling the full potential of the Internet of Things (IoT) [...]

Preeti Samhita Pati ◽  
Shubham Somnath Sahoo ◽  
Chetna Singhal ◽  
Raja Datta

2022 ◽  
Vol 70 (2) ◽  
pp. 2923-2936
Abdul Kadir Hamid ◽  
Fahd N. Al-Wesabi ◽  
Nadhem Nemri ◽  
Ammar Zahary ◽  
Imran Khan

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