Yoga inner beauty as a lifestyle women in Ghanta Yoga Asram Kertalangu Village, East Denpasar

Balinese women today want to feel more beautiful and acceptable in society. Therefore, women do yoga inner beauty which makes practitioners healthy, someone's beauty will shine clearly, and lead to a healthy and harmonious life. In addition, women also need their self-actualization in the form of a career path for them. This study uses a qualitative-analytic method with an interactive approach. The results obtained are as follows. First, the reason why women choose inner beauty yoga at the Ghanta Yoga Asram Denpasar is because women believe that doing inner beauty yoga and meditation every day can radiate inner beauty energy, making the body healthy, beautiful, and youthful. Second, the process of applying inner beauty yoga for women at the Ghanta Yoga Asram Denpasar is starting from socialization, initiation process, worship, the yoga implementation process is carried out from level I to level V and level of purification. Third, the implication of the application of yoga inner beauty for women at the Ghanta Yoga Asram Denpasar is that after participating in yoga, women become more patient, healthier, more beautiful, more harmonious, and more sincere in accepting the situation, and full of confidence.

P165 Use of Initiation checklist to improve compliance with BPAP & CPAP

Introduction Studies have shown that processes used during initiation of non-invasive respiratory (NIV) therapies (including CPAP and BPAP) for children, can influence subsequent compliance with therapy. Methods We implemented a structured checklist as a way of standardising a number of the steps during initiation of NIV in our paediatric sleep medicine service. This study retrospectively reviewed the medical records of children initiated on NIV between Nov 2018 and Dec 2020. We hypothesised that our use of a structured approach to the initiation process, with electronic documentation, would indicate areas in the initiation process that are associated with improved compliance with the therapy, in the long term. Results Initial results revealed that 220 children were commenced on therapy during the 2-year study period (51 BPAP & 169 CPAP). Total numbers with forms present 136 (62%) and complete forms 56 (41%). Forty-six (90%) children commenced on BPAP had forms present and 34 (74%) were completed. Ninety (53%) children commenced on CPAP had forms present and 22 (25%) were completed. Further analyses will evaluate whether sections of the initiation process and checklist (day (of week) of discharge, in-patient vs HITH, attendance at 1st follow-up appointment, financial assistance, severity of disease, eligibility for government-funded equipment) influence compliance when monitored by download at the first, subsequent sleep study. Discussion Use of standardised processes during initiation of NIV therapies can aid in evaluation of the factors that positively influence subsequent compliance with therapy.

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear. We developed a DNA origami-based engulfment system that allows precise nanoscale control of the number and spacing of ligands. When the number of ligands remains constant, reducing ligand spacing from 17.5 nm to 7 nm potently enhances engulfment, primarily by increasing efficiency of the engulfment-initiation process. Tighter ligand clustering increases receptor phosphorylation, as well as proximal downstream signals. Increasing the number of signaling domains recruited to a single ligand-receptor complex was not sufficient to recapitulate this effect, indicating that clustering of multiple receptors is required. Our results suggest that macrophages use information about local ligand densities to make critical engulfment decisions, which has implications for the mechanism of antibody-mediated phagocytosis and the design of immunotherapies.

Dynamics of a simplified nonlinear model offering insights into the hammering type brake squeal initiation process

This article develops a simplified mechanical system model that offers insights into the hammering type brake squeal initiation process while overcoming a void in the literature. The proposed formulation derives a nonlinear two-degree-of-freedom model where a mass is in contact with a rigid frictional surface that moves with constant velocity. The kinematic nonlinearities arise from an arrangement of springs that support the mass, as well as from contact loss between the mass and frictional surface. First, the nonlinear governing equations are numerically solved for several normal force vector arrangements, and a wide range of dynamic responses are observed. Results show that some assumptions made in prior articles are not valid. Second, the nonlinear governing equations are linearized, and the existence of quasistatic sliding motion is sought for selected inclined spring arrangements. Third, the dynamic stability of the linearized system is examined and compared with the results of a nonlinear model. The coupled modes are found even though some contradictions between the model assumptions and linearized system solutions are observed. Finally, the nonlinear frequency responses are calculated using the multi-term harmonic balance method although only the contact loss nonlinearity is retained. Shifts in the resonant frequencies during the motion of the pad are clearly observed. In conclusion, the contact loss nonlinearity is found to be crucial, and as such, it must not be ignored for the squeal source investigation. Finally, the new model offers insight into the squeal initiation process while revealing the limitations of linearized system analyses.

Tight nanoscale clustering of Fcγ-receptors using DNA origami promotes phagocytosis

Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear. We developed a DNA origami-based engulfment system that allows precise nanoscale control of the number and spacing of ligands. When the number of ligands remains constant, reducing ligand spacing from 17.5 nm to 7 nm potently enhances engulfment, primarily by increasing efficiency of the engulfment-initiation process. Tighter ligand clustering increases receptor phosphorylation, as well as proximal downstream signals. Increasing the number of signaling domains recruited to a single ligand-receptor complex was not sufficient to recapitulate this effect, indicating that clustering of multiple receptors is required. Our results suggest that macrophages use information about local ligand densities to make critical engulfment decisions, which has implications for the mechanism of antibody-mediated phagocytosis and the design of immunotherapies.