eb 1089
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Abstract 3539: Vitamin D/EB 1089 mediated radio-sensitization of lung cancer cells and head and neck cancer cells

2016 ◽  
Author(s):  
Theresa Thekkudan ◽  
Khushboo Sharma ◽  
Tareq Saleh ◽  
David Gewirtz
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Lung Cancer Cells ◽  
Eb 1089

scholarly journals A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089

Autophagy ◽  
2014 ◽  
Vol 10 (12) ◽  
pp. 2346-2361 ◽  
Author(s):  
Khushboo Sharma ◽  
Rachel W Goehe ◽  
Xu Di ◽  
Mark Anthony Hicks ◽  
Suzy V Torti ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Vitamin D Analog ◽  
Eb 1089

scholarly journals Assessment of the free binding energy of 1,25-dihydroxyvitamin D3 and its analogs with the human VDR receptor model.

2012 ◽  
Vol 59 (4) ◽  
Author(s):  
Karol Kamel ◽  
Andrzej Kolinski
Keyword(s):  
Binding Energy ◽  
Dihydroxyvitamin D3 ◽  
Dihydroxyvitamin D ◽  
Anticancer Properties ◽  
1,25 Dihydroxyvitamin D ◽  
Distinct Mechanism ◽  
Relative Binding Affinity ◽  
Relative Binding ◽  
Free Binding Energy ◽  
Eb 1089

1,25-dihydroxyvitamin D(3) has quite significant anticancer properties, but its strong calcemic effect in principle excludes it as a potential anticancer drug. Currently, a lot of effort is being devoted to develop potent anticancer analogs of 1,25-dihydroxyvitamin D(3) that would not induce hypercalcemia during therapy. In this work, the free binding energy of the VDR receptor with 1,25-dihydroxyvitamin D(3) and its three potent analogs (EB 1089, KH 1060 and RO 25-9022) is calculated and compared with each other. With this approach, we could estimate the relative binding affinity of the most potent analog, RO 25-9022, and also revealed a quite distinct mechanism of its interaction with VDR.

Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase

2009 ◽  
Vol 10 (12) ◽  
pp. 1951-1959 ◽  
Author(s):  
Stéphane Roy ◽  
Josée Martel ◽  
Harriet S. Tenenhouse
Keyword(s):  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Eb 1089

Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery

2006 ◽  
Vol 5 (11) ◽  
pp. 2786-2797 ◽  
Author(s):  
Gerald DeMasters ◽  
Xu Di ◽  
Irene Newsham ◽  
Robert Shiu ◽  
David A. Gewirtz
Keyword(s):  
Tumor Cells ◽  
Vitamin D3 ◽  
Breast Tumor ◽  
Radiation Sensitivity ◽  
Breast Tumor Cells ◽  
Eb 1089

Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089

2004 ◽  
Vol 92 (5) ◽  
pp. 365-374 ◽  
Author(s):  
Gerald A. DeMasters ◽  
Mona S. Gupta ◽  
Kara R. Jones ◽  
Myles Cabot ◽  
Hongtao Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Vitamin D3 ◽  
Breast Tumor ◽  
Cell Killing ◽  
Breast Tumor Cells ◽  
Eb 1089 ◽  
Fractionated Radiation ◽  
Mcf 7

The tissue-specific distribution of -seocalcitol (EB 1089) and -calcitriol in rats

2004 ◽  
Vol 89-90 ◽  
pp. 43-47 ◽  
Author(s):  
Anne-Marie Kissmeyer ◽  
Jeanet Løgsted Nielsen ◽  
Lise Binderup
Keyword(s):  
Tissue Specific ◽  
Specific Distribution ◽  
Eb 1089

Preclinical Activity of Ketoconazole in Combination With Calcitriol or the Vitamin D Analogue Eb 1089 in Prostate Cancer Cells

2002 ◽  
pp. 1583-1588 ◽  
Author(s):  
DONNA M. PEEHL ◽  
EUGENE SETO ◽  
JU-YU HSU ◽  
DAVID FELDMAN
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Eb 1089 ◽  
Vitamin D Analogue

Preclinical Activity of Ketoconazole in Combination With Calcitriol or the Vitamin D Analogue Eb 1089 in Prostate Cancer Cells

2002 ◽  
Vol 168 (4 Part 1) ◽  
pp. 1583-1588 ◽  
Author(s):  
Donna M. Peehl ◽  
Eugene Seto ◽  
Ju-Yu Hsu ◽  
David Feldman
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Eb 1089 ◽  
Vitamin D Analogue
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