Easy-cone state in spin-torque diode under combined action of magnetostatics and perpendicular anisotropy

Spin-torque diodes (STDs) with interfacial perpendicular magnetic anisotropy (IPMA) in the free layer have outstanding microwave signal rectification performances. Large sensitivity values in such systems are usually associated with an easy cone (EC) magnetic state, when the magnetization in the free layer is tilted from the normal to the plane of the film. Here we theoretically investigate the phase diagram of the existence of an EC state in an infinite free layer of the magnetic tunnel junction (MTJ) considering both IPMA (first and second order) and magnetostatic interaction. We show that the increase of the magnetostatic field leads to extension of the EC existence region. Then we consider the effect of finite dimensions in case of two differently spatially oriented elliptic nanopillar MTJ on the obtained phase diagrams. And finally, we consider dynamic properties and rectification of two elliptic STD under microwave current injection. These results clarify magnetostatic interaction influence on IPMA based STD rectification and demonstrate possible approach to extend the parameters area of the EC STD highly effective rectification.

Spatial Analysis of the Sociodemographic Characteristics, Comorbidities, Hospitalization, Signs, and Symptoms Among Hospitalized Coronavirus Disease 2019 Cases in the State of Rio De Janeiro, Brazil

After more than 1 year from the beginning of the pandemic, the coronavirus disease 2019 (COVID-19) has reached all continents. The number of infected people is still increasing, and Brazil is among the countries with the highest number of registered cases in the world. In this study, we investigated the profile of hospitalized COVID-19 cases and the eventual clusters of similar areas, using geographic information systems. The study was conducted using secondary data. Variables such as sociodemographic characteristics, comorbidities, hospitalization, signs, and symptoms among confirmed cases were considered for each microregion/city of the state of Rio de Janeiro. These proportions were used when calculating the Global Moran's I. The local indicator of spatial association was used to identify local clusters. A significant global spatial auto correlation was found in 28% of the variables. The presence of spatial autocorrelation indicates that the proportions of patients with COVID-19 according to these characteristics are spatially oriented. Moran maps reveal 2 clusters, 1 of high proportions and 1 of low proportions. Understanding the geographic patterns of COVID-19 may assist public health investigators, contributing to actions to prevent and control the pandemic in the state.

The categorical use of a continuous time representation

The abstract concept of time is mentally represented as a spatially oriented line, with the past associated with the left space and the future associated with the right. Although the line is supposed to be continuous, most available evidence is also consistent with a categorical representation that only discriminates between past and future. The aim of the present study was to test the continuous or categorical nature of the mental timeline. Italian participants judged the temporal reference of 20 temporal expressions by pressing keys on either the left or the right. In Experiment 1 (N = 32), all words were presented at the center of the screen. In Experiment 2 (N = 32), each word was presented on the screen in a central, left, or right position. In Experiment 3 (N = 32), all text was mirror-reversed. In all experiments, participants were asked to place the 20 temporal expressions on a 10-cm line. The results showed a clear Spatial–TEmporal Association of Response Codes (STEARC) effect which did not vary in strength depending on the location of the temporal expressions on the line. However, there was also a clear Distance effect: latencies were slower for words that were closer to the present than further away. We conclude that the mental timeline is a continuous representation that can be used in a categorical way when an explicit past vs. future discrimination is required by the task.

Transcriptome and genome evolution during HER2-amplified breast neoplasia

Background The acquisition of oncogenic drivers is a critical feature of cancer progression. For some carcinomas, it is clear that certain genetic drivers occur early in neoplasia and others late. Why these drivers are selected and how these changes alter the neoplasia’s fitness is less understood. Methods Here we use spatially oriented genomic approaches to identify transcriptomic and genetic changes at the single-duct level within precursor neoplasia associated with invasive breast cancer. We study HER2 amplification in ductal carcinoma in situ (DCIS) as an event that can be both quantified and spatially located via fluorescence in situ hybridization (FISH) and immunohistochemistry on fixed paraffin-embedded tissue. Results By combining the HER2-FISH with the laser capture microdissection (LCM) Smart-3SEQ method, we found that HER2 amplification in DCIS alters the transcriptomic profiles and increases diversity of copy number variations (CNVs). Particularly, interferon signaling pathway is activated by HER2 amplification in DCIS, which may provide a prolonged interferon signaling activation in HER2-positive breast cancer. Multiple subclones of HER2-amplified DCIS with distinct CNV profiles are observed, suggesting that multiple events occurred for the acquisition of HER2 amplification. Notably, DCIS acquires key transcriptomic changes and CNV events prior to HER2 amplification, suggesting that pre-amplified DCIS may create a cellular state primed to gain HER2 amplification for growth advantage. Conclusion By using genomic methods that are spatially oriented, this study identifies several features that appear to generate insights into neoplastic progression in precancer lesions at a single-duct level.

‘Spatio-market practices’: conceptualising the always spatial dimensions of market making practices

Socio-material conceptualisations of markets suggest that they are spatial formations. Yet, the everyday practical and spatial dimensions of market making have received little explicit attention. We thus introduce the concept of spatio-market practices, drawing on key ideas in market studies and spatial theory. We argue that examining spatio-market practices (and thus the spatial dimensions of markets) promises to provide fresh insight regarding what it takes to realise markets, their uneven distribution, and what and whom markets are (and are not) designed to serve. To demonstrate what the concept calls for, supports and promises, we take Humphreys’ (2010) influential paper as a starting point and draw on other secondary sources in order to articulate an alternative and spatially-oriented account of the growth and legitimacy of the American casino gambling market. This paper, in turn, contributes a subtle and yet incisive shift in thinking, which supports a more explicit means of exploring markets as spatial formations.