Nitrile Reduction Reverses the Micropollutant Uptake Selectivity of a Tetrafluoroterephthalonitrile-β-Cyclodextrin Polymer

A post-polymerization reduction of nitrile groups to primary amines reverses the selectivity of a crosslinked cyclodextrin polymer network. The as-polymerized material had previously been shown to have a high affinity for cationic organic micropollutants. The reduced polymer has a high affinity for anionic pollutants, including a broad range of per- and polyfluorinated alkyl substances (PFASs).

Nitrile Reduction Reverses the Micropollutant Uptake Selectivity of a Tetrafluoroterephthalonitrile-β-Cyclodextrin Polymer

A post-polymerization reduction of nitrile groups to primary amines reverses the selectivity of a crosslinked cyclodextrin polymer network. The as-polymerized material had previously been shown to have a high affinity for cationic organic micropollutants. The reduced polymer has a high affinity for anionic pollutants, including a broad range of per- and polyfluorinated alkyl substances (PFASs).

Interplay of nucleophilic catalysis with proton transfer in the nitrile reductase QueF from Escherichia coli

Proton relay through an active-site network of hydrogen bonds promotes enzymatic nitrile reduction to amine via a covalent thioimidate enzyme intermediate.

Cobalt-based molecular electrocatalysis of nitrile reduction: evolving sustainability beyond hydrogen

Two complexes, designed as hydrogen evolution catalysts, are shown to be the first earth-abundant molecular electrocatalysts for reduction of acetonitrile to ethylamine.

Facile synthesis of supported Ru–Triphos catalysts for continuous flow application in selective nitrile reduction

Selectivity of immobilized Triphos-type catalysts can be tuned for application in nitrile hydrogenation in batch and continuous flow processes.

Exhaustive Chemoselective Reduction of Nitriles by Catalytic Hydrosilylation Involving Cooperative Si–H Bond Activation

A chemoselective method for the catalytic hydrosilylation of nitriles to either the imine or amine oxidation level is reported. The chemoselectivity is controlled by the hydrosilane used. The usefulness of the nitrile-to-amine reduction is demonstrated for a diverse set of aromatic and aliphatic nitriles, and the amines are easily isolated after hydrolysis as their hydrochloride salts. This exhaustive nitrile reduction proceeds at room temperature.