Synthesis and characterization of new biodegradable gels based on 2,2 '-(ethylenedioxy) diethanethiol and pentaerythritol triacrylate

The work is devoted to the synthesis and characterization of gels based on the monomers pentaerythritol triaacrylate (PETriA) and 2,2 '-(ethylenedioxy)diethanethiol (EDODET) by thiol-ene "click" polymerization. The properties of the obtained gels were investigated by IR, Raman spectroscopy, mechanical analysis. Sol-gel analysis of obtained networks was carried out and the degradability was investigated. The results of IR spectroscopy confirmed the presence of -C = O and -C-O-C- groups in the composition of the obtained gels. The presence of unreacted C = C bonds conjugated with C = O, as well as thiol groups, varies depending on the composition of the initial monomer mixture (IMM). Raman spectroscopy results correlate well with IR data. Raman spectra also show C-S, S-S and SH characteristic bands that are difficult to identify by IR spectroscopy. It was found that the composition of MM affects the physicochemical properties of the synthesized gels. The highest yield of the gel fraction of obtained polymers was found in samples with an equimolar composition of IMM. The analysis of mechanical properties showed that gels with an excess of PETriA exhibit more elastic properties, and an excess of EDODET leads to the formation of networks with a higher crosslinking density. The study of the ability of obtained PETria-EDODET gels to degrade in a 3% solution of hydrogen peroxide showed that the polymer network degrades by 12% within 60 days. This property of the obtained gels can find application in the creation of targeted drug delivery systems with their prolonged release.

Diketopyrrolopyrrole (DPP)-based polytriazoles: Synthesis and Immobilization by click reaction†

Diketopyrrolopyrrole-based polymers are generally immobilized to various surfaces for device fabrications and sensor applications. preparative methods as well as Immobilization processes play a significant role for device efficacy. In this paper, we demonstrated that while "click" polymerization can be conveniently used for the preparation of diketopyrrolopyrrole DPP-based polymer, self-assembled monolayer (SAM) formation technique is convenient for efficient Immobilization to surfaces. Computational models have been used to theoretically calculate various energy parameters. Finally, some of those surfaces have been used as reusable photocatalytic chips, in line with mechanistically similar photovoltaic chips

Preparation and Study Biological Activity of Polybarbiturate Linked Tetrazole Ring

A series of new polymer of barbiturate containing tetrazole ring were synthesized by Click polymerization between diazido and dinitrile derivatives in the existence of NH4Cl as catalyst. The polymers structure were confirmed by several techniques, IR and NMR spectroscopy. The end polymers possess high solubility at room temperatures in aprotic polar solvents for example DMSO and DMF. Thermal properties and stability of the new polymers were analyzed by using two thermal analysis are (TGA) and (DSC) which showed that the polybarbiturate containing tetrazole ring possess Tg value (149–187°C) and excellent thermal stability. The new polytetrazole polymers were screened antibacterial activity by using some kinds strains of Gram-negative and Gram-positive bacteria. The tested polymers displayed good significant against these bacteria.