flash visual evoked potentials
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Author(s):  
Mariana Isa Poci Palumbo ◽  
Luiz Antonio de Lima Resende ◽  
Giovane Olivo ◽  
José Paes de Oliveira-Filho ◽  
Alexandre Secorun Borges


Author(s):  
Xiaohong Meng ◽  
Yanling Long ◽  
Jiayun Ren ◽  
Gang Wang ◽  
Xin Yin ◽  
...  

Bardet–Biedl syndrome (BBS; OMIM 209900) is a rare genetic disease causing damage to multiple organs and affecting patients’ quality of life in late adolescence or early adulthood. In this study, the ocular characteristics including morphology and function, were analyzed in 12 BBS patients from 10 Chinese families by molecular diagnostics. A total of five known and twelve novel variants in four BBS genes (BBS2, 58.33%; BBS4, 8.33%; BBS7, 16.67%; and BBS9, 16.67%) were identified in 10 Chinese families with BBS. All patients had typical phenotypes of retinitis pigmentosa with unrecordable or severely damaged cone and rod responses on full-field flash electroretinography (ffERG). Most of the patients showed unremarkable reactions in pattern visual evoked potential (PVEP) and multifocal electroretinography (mfERG), while their flash visual evoked potentials (FVEP) indicated display residual visual function. Changes in the fundus morphology, including color fundus photography and autofluorescence (AF) imaging, were heterogeneous and not consistent with the patients’ functional tests. Overall, our study expands the variation spectrum of the BBS gene, showing that the ocular characteristics of BBS patients are clinically highly heterogeneous, and demonstrates the usefulness of a combination of the ffERG and FVEP assessments of visual function in the advanced stage of retinopathy in BBS.





2020 ◽  
Vol 42 (1) ◽  
pp. 19-27
Author(s):  
Masayoshi Oguri ◽  
Yoshiaki Saito ◽  
Tohru Okanishi ◽  
Yuka Matuura ◽  
Shota Akiyama ◽  
...  


2018 ◽  
Vol 138 (1) ◽  
pp. 35-42
Author(s):  
Dorota Pojda-Wilczek ◽  
Wojciech Maruszczyk ◽  
Sebastian Sirek


Neurosurgery ◽  
2017 ◽  
Vol 64 (CN_suppl_1) ◽  
pp. 239-239
Author(s):  
Fahad A Alkherayf ◽  
David Houlden ◽  
Chantal Turgeon ◽  
Charles B Agbi ◽  
Andre Lamothe ◽  
...  

Abstract INTRODUCTION Optic nerve/chiasmal injury is a devastating outcome that may happen during endoscopic surgery. A key goal of endoscopic skull-base surgery is visual improvement. Currently, however, there is limited intraoperative visual pathway monitoring. We examine a novel technique that uses continuous flash visual evoked potentials (FVEPs). METHODS Eyes were stimulated by light stimulators (3 LEDs on each side, 640 nm peak wavelength, 10 ms pulse width, 3000 mCd of luminous intensity). Uniform illumination was placed over eyelids. Recording electrodes were placed at Oz-Fz. The filter cuts were = 5 Hz and 100 Hz with amplifier gain 20,000 or 50,000. EEG was recorded. Recordings were correlated to pre and post operative VFs and acuity. Dropping in the FVEP was examined in relation to intraoperative events. A drop of 50% from the base line was considered positive. RESULTS >101 patients had FVEPs in addition to other neurophysiologic monitoring. Patients demographic data, co-morbidities, diagnosis, surgical approach, length of surgery, MAP, and blood loss during surgery were recorded. All patients' visual acuity and field deficits were evaluated by neuro-ophthalmologist before their surgery and within 30 days after surgery. In our cohort, one patient had true positive pre-chiasmatic while another patient had false negative test result. However, the latter patient's deficit was post chiasmatic with no optic nerve or chiasmal injury. Another patient had false positive test (drop of 60%). Eight patients had transient changes related to traction of the chiasm or optic nerves. For predicting optic nerve or chiasmal injury, our study showed sensitivity of 100% (CI2.5-100), specificity of 99% (CI94.5-99.97) and negative predicted value of 100%. CONCLUSION FVEP is reproducible throughout surgery and can predict the post surgical outcome. Additionally, we found that FVEP is transiently affected by different stages of surgery. Further validation is required given the small number of optic/chiasmal injuries in our study.



Author(s):  
F Alkherayf ◽  
D Houlden ◽  
C Turgeon ◽  
C Agbi ◽  
A Lamothe ◽  
...  

Background: Optic nerve/chiasmal injury is a devastating outcome that may happen during endoscopic surgery. Additionally, one of the goals of endoscopic skull-base surgery is visual improvement, currently there is limited ability of intraoperative visual pathway monitoring. We examine a novel technique using continuous flash visual evoked potentials (FVEPs). Methods: Eyes were stimulated by light stimulators (3 LEDs on each side, 640 nm peak wavelength, 10 ms pulse width, 3000 mCd of luminous intensity). Uniform illumination was placed over eyelids. Recording electrodes were placed at Oz-Fz. The filter cuts were ≤5 Hz and 100 Hz with amplifier gain 20,000 or 50,000. EEG was recorded. Recordings were correlated to pre and post operative VFs and acuity. Droop in the FVEP was examined in relation to intraoprative events. Results: Thirty patients had FVEPs in addition to other neurophysiologic monitoring. Patients demographic data, co-morbidities, diagnosis, surgical approach, length of surgery, MAP, and blood loss during surgery were recorded. All patients’ visual acuity and field deficits were evaluated by neuro-opthalmologist before their surgery and within 30 days after surgery. Conclusions: FVEP is reproducible throughout surgery and can predict the post surgical outcome. Additionally, we found that FVEP is transiently affected by different stages of surgery. Also boluses of propofol and electrocautery can artificially affect FVEP.



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