Neighborhood micro-renewal: a perspective of gene in China

PurposeImprovement of the environment quality and human development has become the main focus of modern urban development. Micro-renewal is a relatively people-oriented model of urban transformation compared with traditional renewal modes. To improve the theoretical system of neighborhood micro-renewal from a microcosmic perspective, a comprehensive analysis of neighborhood residents' cognition is needed. The purpose of the study is to explore the possibilities and methods of applying gene theory into the study of neighborhood micro-renewal.Design/methodology/approachAccording to the meme theory, the research explores the genetic analysis of neighborhood micro-renewal. The cross-over studies with “gene theory” from natural science to social science are analyzed and the neighborhood micro-renewal system was constructed from the perspective of micro-participants and micro-objects. Moreover, the concept of neighborhood “micro-renewal gene” was put forward. Finally, the authors show three application scenarios of public participation with a specific neighborhood micro-renewal project.FindingsThe cross research on urban studies with gene theory could be divided into three scales and four research fields. The characteristics of carrying out neighborhood micro-renewal in China could be summarized as micro-participants and micro-objects. Residents' cognition could be considered as “micro-renewal gene” in refer to meme theory. The application scenarios of introducing “micro-renewal gene” into the study of neighborhood renewal are of great potentialities.Originality/valueNeighborhood micro-renewal system was constructed from the perspective of micro-participants and micro-objects. Moreover, neighborhood “micro-renewal gene” was proposed and applied into the study of this system in refer to meme theory.

The Evolved Nest, Virtue, and Vice

The evolved nest provides an evolved baseline for optimizing species-normal development. Any shift away from the evolved nest should be considered a risk factor. Humans are dynamic complex systems that self-organize according to experience, and whose initial conditions shape subsequent development and function, barring later intervention. The evolved nest provides the type of stimulation and support at the right times and in the right ways for healthy development. Developmental psychological studies are beginning to examine nest components, demonstrating their effects on social and moral capacities. Neurobiological studies demonstrate the effects of evolved nest components on human functioning and disposition. We can also observe the vast difference in personality and culture between societies that provide the evolved nest and those that do not. Traditional Indigenous communities provide the nest and demonstrate the natural development of virtue. When the nest is not provided it represents a broken continuum of support and we should not be surprised that various psychopathologies result that promote individual vice and vicious societies. Industrialized capitalist societies have fostered people unable to fit into the biocommunity as fellow members and then have rationalized the disordered result with anthropocentric fatalistic theories like selfish-gene theory. The evolved nest is critical for restoring human nature to its earth-centric origins as found among our ancestors for millions of years.

Possible Nutrition-Related Mechanisms of Metabolic Management in Cancer Treatment

Context: Somatic mutation theory has been considered as a potential cause for cancer. However, major inconsistencies with the gene theory have necessitated serious reconsideration of this assumption. According to these inconsistencies, cancer may be considered as a metabolic disorder. According to the mitochondrial metabolic theory, substrate-level phosphorylation has been suggested to be superior to oxidative phosphorylation in cancer cells. Cancer metabolic therapies such as ketogenic diets (KD) and limitation in glutamine and calorie can be beneficial and are in line with this theory. In this study, we have reviewed the potential effects of KD as well as glutamine and calorie restriction in various types/stages of cancer with a focus on possible mechanisms. Evidence Acquisition: A comprehensive electronic search of different databases was performed using “cancer”, “ketogenic diet”, and “metabolic” as the main keywords. A comprehensive electronic search of different databases was performed using “cancer”, “ketogenic diet”, and “metabolic” as the main keywords. Results: Emerging evidence has indicated that KD can affect tumor cells by reducing glucose availability and simultaneous elevation of ketone bodies as non-fermentable metabolic fuels. KD has been suggested to be more effective as a non-toxic therapeutic measure in combination with glutamine targeting agents, chloroquine for lysosomal targeting, hyperbaric oxygen therapy, and calorie restriction. Conclusions: This metabolic approach can be considered as a promising non-toxic strategy for cancer management.

Medical Bacteriology and Medical Genetics, 1880–1940: A Call for Synthesis

Between 1880 and 1920 the medical quest to unearth the causes of disease saw two pathbreaking discoveries. One was the bacteriological revolution – the identification of specific germs as causal agents of specific diseases (anthrax, tuberculosis, diphtheria, cholera and so on), and the simultaneous effort to develop disinfection techniques and immunisation measures to combat these diseases. The other was the rediscovery of Mendel’s laws of heredity and the resulting emergence of medical genetics, where an entire set of medical maladies (deafness, blindness, bodily deformities, haemophilia, Huntington’s chorea, feeble-mindedness and many mental diseases) were identified – rightly or wrongly – as genetically determined. The ‘germ theory of disease’ and the ‘gene theory of disease’ shared striking, all-too-often overlooked similarities. Both theories built on shared epistemological assumptions that influenced their explanatory mechanisms and their overall conceptual frameworks; both mobilised similar visual and linguistic vocabulary; both appropriated – and enforced – prevailing cultural and gender norms; and both enshrined broadly parallel hygienic practices. Reflecting similar social concerns, medical bacteriology and medical genetics acquired kindred scientific and societal configurations, which this paper highlights and scrutinises.

Evolution and the Parenting Ecology of Moral Development

Evolutionary theory can enrich developmental theory but not just any evolutionary theory will do. Evolutionary systems theory is a developmentally friendly evolutionary theory unlike selfish gene theory because it identifies multiple inheritances beyond genes and takes into account the complex dynamism of development. One inheritance is the species-typical evolved nest, or evolved developmental niche, a set of community provisions that evolved to match up with the maturational schedule of the child. Ethogenesis describes the development of ethics across the life span. We can identify two primary moral inheritances that are fostered by the evolved nest. The first is engagement, or flexible relational attunement, which includes capacities for resonance, reciprocity, mutuality, sympathy, and egalitarian relations with face-to-face others. The second emerges with the development abstracting capabilities that build on engagement capacities into an inclusive communal imagination. A species-typical nest provides what babies and young children need to develop a full human nature.

A Novel Quality Defects Diagnosis Method for the Manufacturing Process of Large Equipment Based on Product Gene Theory

Focusing on the problems of quality information management and quality defects diagnosis in the manufacturing process of large equipment, a novel quality defects diagnosis method based on product gene theory and knowledge base was developed. First, a product gene model and a sectional encoding method for the quality control of the manufacturing process of large equipment were proposed. In that model, the processing surface was the minimum information granularity to meet the production characteristics of large equipment and to improve the flexibility of the product gene model. Then, a similarity evaluation rule and an optimization method of the weights of elements based on particle swarm optimization (PSO) were addressed to filter the available knowledge of product gene from the product gene knowledge base. Aiming at the characteristic of many-to-many between quality defects and quality influence factors in some cases, a fuzzy comprehensive evaluation (FCE) method was developed for the further localization of diagnosis knowledge. Finally, an experiment of bearing spacer was applied to illustrate the proposed quality diagnosis approach. In the experiment, the data from the target gene and knowledge genes were described reasonably. On this basis, available knowledge genes could be accurately filtered with the proposed similarity rule and the method of filtration, where the PSO was proved to be effective. The diagnosis results of the experiment show that multiple factors lead to the defects that were verified. Therefore, the proposed quality defects diagnosis method is an effective way for quality control.