Neurologic Sequelae Associated with Hypertensive Disorders of Pregnancy

Hypertensive disorders of pregnancy (HDP) contribute to adverse gene-environment interactions prior to conception and continue throughout pregnancy. Embryonic/fetal brain disorders occur from interactions between genetic susceptibilities interacting with acquired diseases or conditions affecting the maternal/placental fetal (MPF) triad. Trimester-specific pathophysiological mechanisms, such as maternal immune activation and ischemic placental syndrome, contribute to adverse peripartum, neonatal and childhood outcomes. Two diagnostic approaches provide timelier diagnoses over the first 1000 days from conception until two years of age. Horizontal analyses assess the maturation of the triad, neonate and child. Vertical analyses consider systems-biology from genetic, molecular, cellular, tissue through organ networks during each developmental niche. Disease expressions associated with HDP have cumulative adverse effects across the lifespan when subjected to subsequent adverse events. Critical/sensitive periods of developmental neuroplasticity over the first 1000 days are more likely to result in permanent sequelae. Novel diagnostic approaches, beginning during pre-conception, will facilitate the development of effective preventive, rescue and reparative neurotherapeutic strategies in response to HDP-related trimester-specific disease pathways. Public health policies require the inclusion of women’s health advocacy during and beyond their reproductive years to reduce sequelae experienced by mothers and their offspring. A lower global burden of neurologic disease from HDP will benefit future generations.

Effect of density and species preferences on collective choices: an experimental study on maggot aggregation behaviours

ABSTRACTCollective decisions have been extensively studied in arthropods, but they remain poorly understood in heterospecific groups. This study was designed to (1) assess the collective behaviours of blow fly larvae (Diptera: Calliphoridae) in groups varying in density and species composition, and (2) relate them to the costs and benefits of aggregating on fresh or decomposed food. First, experiments testing conspecific groups of Lucilia sericata and Calliphora vicina larvae, two species feeding at the same time on fresh carcasses, demonstrated decreases in growth and survival on rotten beef liver compared with fresh liver. However, mixing species together reduced this adverse impact of decomposition by increasing the mass of emerged adults. Second, larval groups were observed in binary choice tests between fresh and rotten liver (i.e. optimal and sub-optimal food sources). The results showed that larvae interacted with each other and that these interactions influenced their food preferences. We observed that (1) larvae were able to collectively choose the optimal food, (2) their choice accuracy increased with larval density and (3) the presence of another species induced a reversal in larval preference towards rotten food. These results highlight the ubiquity of collective decision properties in gregarious insects. They also reveal an unexpected effect of interspecific association, suggesting the colonization of new resources through a developmental niche construction.

Limiting the explanatory scope of extended active inference: the implications of a causal pattern analysis of selective niche construction, developmental niche construction, and organism-niche coordination dynamics

Research in evolutionary biology and philosophy of biology and cognition strongly suggests that human organisms modify their environment through active processes of niche construction. Recently, proponents of the free-energy principle and variational active inference have argued that their approach can deepen our understanding of the reciprocal causal relationship between organisms and their niche on various scales. This paper examines the feasibility and scope of variational formalisations and conceptualisations of the organism-niche nexus with a particular focus on the extended active inference account. I will draw a conceptual distinction between selective niche construction, developmental niche construction, and organism-niche coordination dynamics and argue that these notions capture different causal patterns, each of which with a distinct scope. Against this background, I will analyse and discuss the extended active inference account and its strategy to integrate variational active inference with work on extended cognition. The proponents of extended active inference assume that their account can provide an explanation of selective niche construction, developmental niche construction, and organism-niche coordination dynamics. However, my key claim will be that this account has the potential to elucidate the workings of organism-niche coordination dynamics, but does not adequately capture the causal patterns of selective niche construction and developmental niche construction.

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission and Map2k7 expression in GABAergic interneurons

Intellectual disability is closely related to impaired GABA neurotransmission. Brpf1 was specifically expressed in medial ganglionic eminence (MGE), a developmental niche of GABAergic interneurons, and patients with BRPF1 mutations were mentally retarded. To test its role in development and function of MGE-derived GABAergic interneurons, we performed immunofluorescence staining, whole-cell patch-clamp, MGE transplantation and mRNA-Seq to understand its effect on neuronal differentiation, dendritic morphology, electrophysiology, migration and gene regulation, using mouse MGE-derived GABAergic interneurons infected with AAV-shBrpf1. We found a decreasing trend on parvalbumin+ interneuron differentiation. Moreover, increased firing threshold, decreased number of evoked APs, and a reduced amplitude of mIPSCs were observed before any significant change of MAP2+ dendritic morphology and in vivo migration appeared. Finally, mRNA-Seq analysis revealed that genes related to neurodevelopment and synaptic transmission such as Map2k7 were dysregulated. Our results demonstrated a key role of Brpf1 in inhibitory neurotransmission and related gene expression of GABAergic interneurons.

Culture-Sensitive Communication in Applied Developmental Research

Communication about child development between persons with different cultural preoccupations requires that author and audience agree without coercion on how to connect their perspectives. Western cultural hegemony persists in many international fora under the guise of “globalization,” giving rise to systematically distorted communication in ways that do epistemological violence to indigenous cultural models in Africa. The dominant paradigm of public basic schooling is sustained by institutionalized path dependency and construes educational success as extracting the learner from her community of origin. Consensus-building within a framework of mutually respectful communication involves bridging, coordination or fusion. Societal progress is a different kind of “development” than ontogenesis. A given cultural group’s developmental niche for its children is part of a chronosystem that changes over the course of history. An individual’s transactions with significant others are embedded in a complex and dynamic sociocultural system, to which programming of early childhood education should respond.

The Timing of Brain Maturation, Early Experience and the Human Social Niche

Book section— in 2017, J. Kaas (Ed.), Evolution of Nervous Systems, 2nd Edition, Vol. 3. San Diego: Elsevier Academic Press.Human neurodevelopment is described in terms of its predictable scaling relationships with primate and general mammalian development. The highly predictable, stepwise nature of early brain development, including neurogenesis, axon extension and synaptogenesis, circuit assembly and initial behavior is contrasted with the more malleable nature of brain development as it interacts with the life history events of birth and weaning, which occur at variable times with respect to neural maturation. The early birth and weaning in humans places them in an unusual developmental niche, decoupled from unique association with the mother, for most of their extended development.

Differences in Retrospective Perceptions of Parenting Among Adolescents and Young Adults

In the present study, the possible differences in parenting perceptions between young people socialised before the political changes in the socialist regime and those born after the regime change were explored. In Study 1 (2002) and Study 2 (2018), adolescents and young adults’ retrospective perceptions of parenting were examined. In the first study, the participants included 126 adolescents and 145 young adults, and there were 133 adolescents and 204 young adults in the second study. In both studies, the participants completed the Family Socialisation Questionnaire (Dalbert & Goch, 1997), which is employed to assess parenting practices retrospectively. Second order factor analyses on both occasions revealed that the age groups perceived parenting styles in a similar way. The similarities of the two age groups’ perceptions of parenting could be explained by employing the developmental niche theory, which is when the homeostatic functioning of the niche ensures relatively stable parenting styles, despite changing circumstances. On both occasions, young adults perceived parenting as more negative and restrictive. These results are discussed in detail.

Evolution and the Parenting Ecology of Moral Development

Evolutionary theory can enrich developmental theory but not just any evolutionary theory will do. Evolutionary systems theory is a developmentally friendly evolutionary theory unlike selfish gene theory because it identifies multiple inheritances beyond genes and takes into account the complex dynamism of development. One inheritance is the species-typical evolved nest, or evolved developmental niche, a set of community provisions that evolved to match up with the maturational schedule of the child. Ethogenesis describes the development of ethics across the life span. We can identify two primary moral inheritances that are fostered by the evolved nest. The first is engagement, or flexible relational attunement, which includes capacities for resonance, reciprocity, mutuality, sympathy, and egalitarian relations with face-to-face others. The second emerges with the development abstracting capabilities that build on engagement capacities into an inclusive communal imagination. A species-typical nest provides what babies and young children need to develop a full human nature.

Understanding Parental Ethnotheories and Practices About Healthy Eating: Exploring the Developmental Niche of Preschoolers

Purpose: To understand parental ethnotheories (ie, belief systems) and practices about preschoolers’ healthy eating guided by the developmental niche framework. Design: Qualitative hermeneutic phenomenology. Setting: Home. Participants: Participants were 20 parents of preschool-age children ages 3 to 5 years, recruited from a quantitative investigation. A majority of the participants were white, female, married, well educated, and working full time. Methods: Participants who completed the quantitative survey were asked to provide their contact information if they were willing to be interviewed. From the pool of participants who expressed their willingness to participate in the interviews, 20 participants were selected using a random number generator. In-person semistructured interviews were conducted until data saturation (n = 20). Thematic analysis was performed. Results: Three themes and 6 subthemes emerged: theme 1—parental ethnotheories about healthy eating included subthemes of knowledge about healthy eating, motivations to promote healthy child development through healthy eating, and sources of knowledge about healthy eating (eg, doctors, social media, government guidelines, positive family-of-origin experiences); theme 2—parental ethnotheories that supported organization of children’s physical and social settings included structured mealtime routines and food socialization influences (eg, grandparents, siblings, and childcare programs); and theme 3—parental ethnotheories that supported children’s learning about healthy eating included parent–child engagement, communication, and encouragement in food-related activities (eg, meal preparation, visiting farmer’s market, grocery shopping, gardening, cooking, baking). Conclusion: Findings advance the literature on parental practices about healthy eating. Parental ethnotheories (eg, beliefs, motivations, knowledge, and skills) matter. Developmental niche of preschoolers (ie, physical and social settings, childrearing practices, and parental ethnotheories) constitutes an interactive system in which ethnotheories serve as guides to parental practices. Fostering nutrition education and parent–child engagement, communication, and encouragement in food-related activities are recommended to promote children’s healthy eating in daily routines.