Effects of Curcuma Zedoaria (Shoti) on Growth Performance and Hemato-Biochemical Parameters in Broiler

The experiment was conducted on “Cobb-500” broiler chicks to study the effects of Curcumazedoaria (shoti) on growth performances and haemato-biochemical parameters. A total of twentybroilers chicks (16 days old) were randomly divided into five equal groups (n=4). Three groups ofbroilers fed shoti powder at the rate of 10%; 20%; 30% (w/w) with other ingredients for 22 days.Broilers chicks fed on maize-soybean were considered as positive control while non-protein controlwas regarded as negative control. The results showed that body weight of broilers fed 10% and 20%shoti meal grew very close to those of control (maize-soybean) group. After having completed thefeeding trial, the birds were sacrificed to collect blood sample for and biochemical analysis .Weightsof different organs and length of intestine were also measured. Results showed that decreaseddressed weight, weight of skin and liver were found in 30% shoti treated group compared to proteincontrol group. Intestinal weight was highest in 30% shoti treated group but length was similar to theprotein control group. Total erythrocytes count, hemoglobin content and PCV value were founddecreased in shoti treated group compared to protein control group but ESR value was highest in10% shoti treated group. Total cholesterol was found to be decreased in the birds fed on shoticompared to protein control and significantly higher than non-protein control group. Triglyceride valuedecreased in 10% shoti treated group compared to protein and non-protein control group. IncreasedHDL value was found in 10% shoti treated group compared to control groups and 20 % and 30 %shoti treated groups. Result of this experiment showed that body weight of birds significantly (p<0.05)increased in all shoti treated groups. Further investigations are necessary by using differentpercentages of shoti and other shoti type feed to determine the effects of this feed supplement onanimal’s physiology. Res. Agric., Livest. Fish.7(2): 293-301, August 2020

Efficacy of probiotics on growth performance and hemato-biochemical parameters in broiler

Cobb-500 broiler chicks were used to study the effects of probiotics on growth performances and haemato-biochemical parameters. A total of fifteen broiler chicks (16 days old) were randomly divided into three equal groups (n=5). Two groups of broilers were fed probiotics at the rate of 0.5 gm/kg and 1gm/kg respectively with commercial feed for 22 days. Chicks fed on only commercial feed were considered as control group. The results showed that broilers treated with probiotics grew faster compared to control group. After having completed the trial, the birds were sacrificed to collect blood sample for hematological and biochemical analysis. Dressed weight, weight of skin including feathers, leg weight, breast weight and liver weight were found higher in treated groups compared to control group. Total erythrocytes count and hemoglobin content were found increased in treated group compared to control group. ESR value was found decrease in treated groups compared to control group. Total cholesterol, triglycerides and HDL was significantly (P>0.01) lower in the treated groups compared to control group. The serum alkaline phosphatase significantly (P<0.01) increased in treated groups. Res. Agric., Livest. Fish.6(1): 91-100, April 2019

Isavuconazole therapeutic drug monitoring associated to a pharmacogenetic exploration is far from being a pharmacologists’ whim

ABSTRACTIsavuconazole is a new antifungal prodrug to treat invasive aspergillosis and mucormycosis, theoretically not requiring drug monitoring. However, we reported 4 clinical cases with toxic concentrations. Based on Desai’s population pharmacokinetic model, we estimated patients’ kinetic profile. Clearance was abnormally low, likely related to CYP3A4/5 polymorphisms. Thus, we recommend to collect blood sample just before the first maintenance dose to estimate pharmacokinetic profile and individualized dose. For patients presenting high concentrations, pharmacogenetics can be done.