Functional and Structural Aging of the Vestibular System

Purpose Aging is ubiquitous and the elderly population (aged 65 years and older) will continue to grow, reaching an estimated 25% of the U.S. population by 2060. Symptoms of dizziness and imbalance as well as risk of falling are more common in older adults, but it is often unclear whether these symptoms are due to disease or a consequence of aging. Indeed, age-related changes in the vestibular periphery are not well understood. This invited review describes age-related changes in peripheral vestibular function, comparisons between aging of auditory and vestibular function, structural correlates for vestibular aging, and the role of genetics in vestibular aging. Conclusion The data from animal models will show that gravity receptor function declines with age but at different rates for different inbred mouse strains. Gravity receptor aging includes loss of postsynaptic elements and loss of hair cells, which is observed at advanced ages. Loss of hair cells may contribute to some extent at advanced ages. Age-related changes in hearing do not predict age-related changes in vestibular function. Genes likely influence the rate of decline in vestibular function. Further research is needed to fully understand the fundamental mechanisms of vestibular aging and to begin to develop potential therapeutic approaches.

Settling for Less: Do Statoliths Modulate Gravity Perception?

Plants orientate their growth either towards (in roots) or away from (in shoots) the Earth’s gravitational field. While we are now starting to understand the molecular architecture of these gravity response pathways, the gravity receptor remains elusive. This perspective looks at the biology of statoliths and suggests it is conceivable that their immediate environment may be tuned to modulate the strength of the gravity response. It then suggests how mutant screens could use this hypothesis to identify the gravity receptor.

Multiple convergent evolution of arboreal life in oribatid mites indicates the primacy of ecology

Frequent convergent evolution in phylogenetically unrelated taxa points to the importance of ecological factors during evolution, whereas convergent evolution in closely related taxa indicates the importance of favourable pre-existing characters (pre-adaptations). We investigated the transitions to arboreal life in oribatid mites (Oribatida, Acari), a group of mostly soil-living arthropods. We evaluated which general force—ecological factors, historical constraints or chance—was dominant in the evolution of arboreal life in oribatid mites. A phylogenetic study of 51 oribatid mite species and four outgroup taxa, using the ribosomal 18S rDNA region, indicates that arboreal life evolved at least 15 times independently. Arboreal oribatid mite species are not randomly distributed in the phylogenetic tree, but are concentrated among strongly sclerotized, sexual and evolutionary younger taxa. They convergently evolved a capitate sensillus, an anemoreceptor that either precludes overstimulation in the exposed bark habitat or functions as a gravity receptor. Sexual reproduction and strong sclerotization were important pre-adaptations for colonizing the bark of trees that facilitated the exploitation of living resources (e.g. lichens) and served as predator defence, respectively. Overall, our results indicate that ecological factors are most important for the observed pattern of convergent evolution of arboreal life in oribatid mites, supporting an adaptationist view of evolution.

Control of gravitropic orientation. II. Dual receptor model for gravitropism

Gravitropism of vascular plants has been assumed to require a single gravity receptor mechanism. However, based on the evidence in Part I of this study, we propose that maize roots require two. The first mechanism is without a directional effect and, by itself, cannot give rise to tropism. Its role is quantitative facilitation of the second mechanism, which is directional like the gravitational force itself and provides the impetus for tropic curvature. How closely coupled the two mechanisms may be is, as yet, unclear.The evidence for dual receptors supports a general model for roots. When readiness for gravifacilitation, or gravifacilitation itself, is constitutive, orthogravitropic curvature can go to completion. If not constitutively enabled, gravifacilitation can be weak in the absence of light and water deficit or strong in the presence of light and water deficit. In either case, it can decay and permit roots to assume reproducible non-vertical orientations (plagiogravitropic or plagiotropic orientations) without using non-vertical setpoints. In this way roots are deployed in a large volume of soil.Gravitropic behaviours in shoots are more diverse than in roots, utilising oblique and horizontal as well as vertical setpoints. As a guide to future experiments, we assess how constitutive v. non-constitutive modes of gravifacilitation might contribute to behaviours based on each kind of setpoint.