Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes

Background: Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) as well as non-fluent/agrammatic primary progressive aphasia (naPPA) are often associated with misfolded 4-repeat tau pathology, but the diversity of the associated speech features is poorly understood. Objective: Investigate the full range of acoustic and lexical properties of speech to test the hypothesis that PSPS-CBS show a subset of speech impairments found in naPPA. Methods: Acoustic and lexical measures, extracted from natural, digitized semi-structured speech samples using novel, automated methods, were compared in PSPS-CBS (n = 87), naPPA (n = 25), and healthy controls (HC, n = 41). We related these measures to grammatical performance and speech fluency, core features of naPPA, to neuropsychological measures of naming, executive, memory and visuoconstructional functioning, and to cerebrospinal fluid (CSF) phosphorylated tau (pTau) levels in patients with available biofluid analytes. Results: Both naPPA and PSPS-CBS speech produced shorter speech segments, longer pauses, higher pause rates, reduced fundamental frequency (f0) pitch ranges, and slower speech rate compared to HC. naPPA speech was distinct from PSPS-CBS with shorter speech segments, more frequent pauses, slower speech rate, reduced verb production, and higher partial word production. In both groups, acoustic duration measures generally correlated with speech fluency, measured as words per minute, and grammatical performance. Speech measures did not correlate with standard neuropsychological measures. CSF pTau levels correlated with f0 range in PSPS-CBS and naPPA. Conclusion: Lexical and acoustic speech features of PSPS-CBS overlaps those of naPPA and are related to CSF pTau levels.

CYCLIC PARTIAL WORDS

Partial words are linear words with holes. Cyclic words are derived from linear words by linking its first letter after the last one. Both partial words and cyclic words have wide applications in DNA sequencing. In this paper we introduce cyclic partial words and discuss their periodicity and certain properties. We also establish representation of a cyclic partial word using trees.

WAGE: An Authenticated Encryption with a Twist

This paper presents WAGE, a new lightweight sponge-based authenticated cipher whose underlying permutation is based on a 37-stage Galois NLFSR over F27. At its core, the round function of the permutation consists of the well-analyzed Welch-Gong permutation (WGP), primitive feedback polynomial, a newly designed 7-bit SB sbox and partial word-wise XORs. The construction of the permutation is carried out such that the design of individual components is highly coupled with cryptanalysis and hardware efficiency. As such, we analyze the security of WAGE against differential, linear, algebraic and meet/miss-in-the-middle attacks. For 128-bit authenticated encryption security, WAGE achieves a throughput of 535 Mbps with hardware area of 2540 GE in ASIC ST Micro 90 nm standard cell library. Additionally, WAGE is designed with a twist where its underlying permutation can be efficiently turned into a pseudorandom bit generator based on the WG transformation (WG-PRBG) whose output bits have theoretically proved randomness properties.

Square-Free Partial Words with Many Wildcards

We contribute to the study of square-free words. The classical notion of a square-free word has a natural generalization to partial words, studied in several papers since 2008. We prove that the maximal density of wildcards in the ternary infinite square-free partial word is surprisingly big: [Formula: see text]. Further we show that the density of wildcards in a finitary infinite square-free partial words is at most [Formula: see text] and this bound is reached by a quaternary word. We demonstrate that partial square-free words can be viewed as “usual” square-free words with some letters replaced by wildcards and introduce the corresponding characteristic of infinite square-free words, called flexibility. The flexibility is estimated for some important words and classes of words; an interesting phenomenon is the existence of “rigid” square-free words, having no room for wildcards at all.

KLASIFIKASI BENTUK SHOURYAKUGO DALAM BAHASA JEPANG

This research aims to describe the classification of shouryakugo forms in printed media like newspaper and magazine. The form of words shortening in Japanese in newspapers and magazines became the main object in this research. The type of research is qualitative descriptive research. The object in this study is new words formed from the shortening process or shouryakugo contained in printed media such as The Daily Jakarta Shinbun newspaper and Nipponika magazine. The result of the research shows that there are total of 14 data of shouryakugo, of which 2 data is shortening at the beginning of word, 3 data of shortening in middle of word, 3 data of shortening at end of word, 5 data by removing partial word from word series, and 1 data shouryakugo by eliminating besides one word. Keywords: Classification, Forms, Shouryakugo