follicular targeting
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Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1322
Author(s):  
Eloy Pena-Rodríguez ◽  
Aida Mata-Ventosa ◽  
Laura Garcia-Vega ◽  
Sandra Pérez-Torras ◽  
Francisco Fernández-Campos

Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectants. Sucrose was selected because it allowed for a good resuspension and provided acceptable physicochemical parameters (374.33 nm, +34.7 mV, polydispersion 0.229%, and 98.87% encapsulation efficiency). The nanoparticles obtained were loaded into a pleasant xanthan gum hydrogel, and the rheological, release, and skin permeation profiles of different formulations were studied. The FD formulation significantly modified the particle size, and the drug release and permeation properties were also altered. In addition, analyses of the cytotoxicity and anti-inflammatory efficacy of FD and non-FD particles on human keratinocytes indicated no differences.



Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 533
Author(s):  
Eloy Pena-Rodríguez ◽  
Maria Lajarin-Reinares ◽  
Aida Mata-Ventosa ◽  
Sandra Pérez-Torras ◽  
Francisco Fernández-Campos

Follicular targeting has gained more attention in recent decades, due to the possibility of obtaining a depot effect in topical administration and its potential as a tool to treat hair follicle-related diseases. Lipid core ethyl cellulose lipomers were developed and optimized, following which characterization of their physicochemical properties was carried out. Dexamethasone was encapsulated in the lipomers (size, 115 nm; polydispersity, 0.24; zeta-potential (Z-potential), +30 mV) and their in vitro release profiles against dexamethasone in solution were investigated by vertical diffusion Franz cells. The skin biodistribution of the fluorescent-loaded lipomers was observed using confocal microscopy, demonstrating the accumulation of both lipomers and fluorochromes in the hair follicles of pig skin. To confirm this fact, immunofluorescence of the dexamethasone-loaded lipomers was carried out in pig hair follicles. The anti-inflammatory (via TNFα) efficacy of the dexamethasone-loaded lipomers was demonstrated in vitro in an HEK001 human keratinocytes cell culture and the in vitro cytotoxicity of the nanoformulation was investigated.



2021 ◽  
Vol 11 (2) ◽  
pp. 626-646
Author(s):  
Beyza B. Gökçe ◽  
Tuğçe Boran ◽  
Filiz Emlik Çalık ◽  
Gül Özhan ◽  
Rana Sanyal ◽  
...  


2020 ◽  
Vol 59 ◽  
pp. 101908
Author(s):  
Stephani Araujo Cardoso ◽  
Thaís Nogueira Barradas


Nanocosmetics ◽  
2020 ◽  
pp. 305-326
Author(s):  
B. Betül Gökçe ◽  
Sevgi Güngör
Keyword(s):  


2019 ◽  
Vol 24 (7) ◽  
pp. 812-823 ◽  
Author(s):  
Parisa Ghasemiyeh ◽  
Amir Azadi ◽  
Saeid Daneshamouz ◽  
Reza Heidari ◽  
Negar Azarpira ◽  
...  


Pharmaceutics ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 19 ◽  
Author(s):  
Eman Abd ◽  
Heather Benson ◽  
Michael Roberts ◽  
Jeffrey Grice


2017 ◽  
Vol 524 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
Francesco Corrias ◽  
Michele Schlich ◽  
Chiara Sinico ◽  
Rosa Pireddu ◽  
Donatella Valenti ◽  
...  


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