This paper proposes a method of drawing natural and full of vitality printed original, adopting Sketchpad online painting software to simulate artificial hand-painted, and combines traditional plate-making technique to reappear the decoraton pictures of food packaging.The optimized process parameters are obtained through experiments, in order to provide technicalreference for designing and making new decoration printing products of food packaging based on the digital hand-painted plate-making in quantity. The results show that the optimized process parameters when printing pressure is 2.5kgf/cm2,the angel of scraper is 70° , screen distance is 9mm, mesh count is 200mesh/cm, are more suitable to present decoration effect required by food packaging, and the color error of printing products on the substrate of paper material is minimum. Contrasting the picture decoration effect presented by printing products shows that, the art hand-painted expression of food color, shape and taste based on sketchpad software possesses the advantage in enriching aesthetics of food packaging design and restoring reality of the sale food, The purpose is to help consumers know the food clearly, furthermore improve quality and market competitiveness of food packaging.