Religious topics are increasingly common in video games, frequently addressing issues such as spirituality and transcendence. Yet this is only the surface of more complex phenomena, deeply tied to religious experience itself in interactive digital simulations. The aim of the chapter is to highlight the implications of the ties between religion and belief dynamics in video games. First, it focuses on different kinds of player–game belief relationships, which take the forms of agreements (symmetrical) and self-givings (asymmetrical). Then, it addresses the process of institution of belief: the necessity for players not only to pretend to believe in the digital world, but to experience the act of believing itself while playing. Lastly, it presents a series of case studies (Planescape Torment, Nier: Automata, The Talos Principle, and The Stanley Parable) to show different peculiar dynamics involved in the relationships between religio, belief, and the ludic experience.